New daily pill could help millions lose weight and control diabetes
NCT ID NCT06972472
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial is testing a once-daily pill called orforglipron in 600 adults who are overweight or have obesity and also have type 2 diabetes. The study compares the drug to a placebo to see if it helps lower blood sugar and body weight over about 18 months. Participants must have a BMI of 25 or higher and have tried to lose weight before without lasting success.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- orforglipron (a daily pill)
- What this could lead to
- If it works, this could lead to a new once-daily pill that helps people with obesity and type 2 diabetes lose weight and better control their blood sugar.
- What could go wrong
- This is still a Phase 3 trial, so results are not yet confirmed. The drug may not work better than placebo, and side effects are possible. It is not a cure—ongoing management of diabetes and weight is still needed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Accel Research Sites - DeLand Clinical Research Unit
DeLand, Florida, 32720, United States
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Accel Research Sites - NeuroStudies Clinical Research Unit
Decatur, Georgia, 30030, United States
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Activian Clinical Research
Kingwood, Texas, 77339, United States
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AmBeNet GmbH
Leipzig, 04107, Germany
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Biopharma Informatic, LLC
Houston, Texas, 77043, United States
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Boeson Research MSO
Missoula, Montana, 59804, United States
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CARE - Centro de Alergia y Enfermedades Respiratorias
Buenos Aires, 1414, Argentina
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CIPREC
Buenos Aires, C1119ACN, Argentina
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Care Access - Decatur
Decatur, Georgia, 30030, United States
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Care Access - Fayetteville
Fayetteville, North Carolina, 28314, United States
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Care Access - New Iberia
New Iberia, Louisiana, 70560, United States
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Care Access - Tampa
Tampa, Florida, 33625, United States
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Care Access - Thousand Oaks
Thousand Oaks, California, 91360, United States
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Centro Médico Viamonte
Buenos Aires, C1120AAC, Argentina
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Centro de Diagnóstico y Rehabilitación (CEDIR)
Santa Fe, 3000, Argentina
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Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, 85375, United States
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Clinical Research of Philadelphia
Philadelphia, Pennsylvania, 19114, United States
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Conquest Research
Winter Park, Florida, 32789, United States
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Consano Clinical Research, LLC
Shavano Park, Texas, 78231, United States
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Diabetes Zentrum Wilhelmsburg
Hamburg, 21109, Germany
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Donmed s.r.o.
Ostrava, 710 00, Czechia
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Encore Medical Research
Hollywood, Florida, 33024, United States
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Endocrine and Metabolic Consultants
Rockville, Maryland, 20852, United States
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Frontier Clinical Research, LLC
Smithfield, Pennsylvania, 15478, United States
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Fukuwa Clinic
Chūōku, 104-0031, Japan
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Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut
Leipzig, 04249, Germany
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Great Lakes Research Group, Inc.
Bay City, Michigan, 48706, United States
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Hasegawa Medicine Clinic
Chitose, 066-0032, Japan
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Indago Research & Health Center, Inc
Hialeah, Florida, 33012, United States
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InnoDiab Forschung Gmbh
Essen, 45136, Germany
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Innovation Medical Research Center - Fort Lauderdale
Fort Lauderdale, Florida, 33316, United States
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Instituto Centenario
CABA, 1204, Argentina
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Instituto Médico Catamarca IMEC
Rosario, 2000, Argentina
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Isis Clinical Research Center
Guaynabo, 00968, Puerto Rico
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Javara - Nevada Health Centers - Carson City
Carson City, Nevada, 89706, United States
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Javara - Privia Medical Group - Silver Spring
Silver Spring, Maryland, 20901, United States
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Javara - Privia Medical Group Georgia - Savannah
Savannah, Georgia, 31406, United States
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Javara - Tryon Medical Partners
Charlotte, North Carolina, 28210, United States
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Jinan Central Hospital
Jinan, 250013, China
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MUDr. Alena Vachova
České Budějovice, 37011, Czechia
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Medical Corporation Heishinkai OCROM Clinic
Suita-shi, 565-0853, Japan
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Medical Corporation Heishinkai ToCROM Clinic
Shinjuku-ku, 160-0008, Japan
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Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic
Yamato-shi, 242-0004, Japan
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Medical Plus
Uherské Hradiště, 686 01, Czechia
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Medicover Neuroendokrinologie
Munich, 81667, Germany
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Medizentrum Essen Borbeck
Essen, 45355, Germany
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Milan Kvapil s.r.o., Diabetologicka ambulance
Prague, 14900, Czechia
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Nemocnice Cesky Krumlov
Český Krumlov, 381 01, Czechia
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Norcal Endocrinology & Internal Medicine
San Ramon, California, 94583, United States
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Noritake Clinic
Ushiku, 300-1207, Japan
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North Georgia Clinical Research
Woodstock, Georgia, 30189, United States
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Novak Clinical Research - Tucson - North La Cholla Boulevard
Tucson, Arizona, 85741, United States
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Olive Takamatsu Medical Clinic
Takamatsu, 760-0076, Japan
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Peking University Third Hospital
Beijing, 100091, China
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Puerto Rico Health and Wellness Institute
Dorado, 00646, Puerto Rico
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RED-Institut GmbH
Oldenburg, 23758, Germany
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Shimokitazawa Tomo Clinic
Tokyo, 155-0031, Japan
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Sichuan Provincial People's Hospital
Chengdu, 610072, China
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Solaris Clinical Research
Meridian, Idaho, 83646, United States
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Southern California Clinical Research
Santa Ana, California, 92701, United States
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Texas Valley Clinical Research (TVCR) - Mission
Mission, Texas, 78572, United States
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The Corvallis Clinic, P.C.
Corvallis, Oregon, 97330, United States
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The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, 471003, China
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The Fourth Affiliated Hospital of Harbin Medical University
Harbin, 150001, China
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The Institute of Medical Science, Asahi Life Foundation
Chūōku, 103-0002, Japan
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The Machuca Foundation
Las Vegas, Nevada, 89101, United States
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The Second Affiliated Hospital Chongqing Medical University
Chongqing, 400010, China
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The Second Affiliated Hospital of Nanjing Medical University
Nanjing, 210011, China
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The Second Hospital of Tianjin Medical University
Tianjin, 300211, China
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The Second People's Hospital of Hefei
Hefei, 230011, China
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Tokuyama Clinic
Mihama-ku,Chiba City, 261-0004, Japan
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Tokyo-Eki Center-building Clinic
Chūōku, 103-0027, Japan
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Tsuchiura Medical & Health Care Center
Tsuchiura, 300-0012, Japan
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University of North Carolina Medical Center
Chapel Hill, North Carolina, 27514, United States
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Velocity Clinical Research, Dallas
Dallas, Texas, 75230, United States
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West Orange Endocrinology P.A.
Ocoee, Florida, 34761, United States
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Xuanwu Hospital Capital Medical University
Beijing, 100053, China
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Yokohama Minoru Clinic
Yokohama, 232-0064, Japan
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Zhongda Hospital Southeast University
Nanjing, 210009, China
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Zhujiang Hospital
Guangzhou, 510280, China
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