Veterans test One-Day-a-Week fasting to beat weight regain

NCT ID NCT04131647

Ongoing Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether intermittent fasting (eating only two small meals one day per week) can help overweight veterans maintain weight loss after a 12-week diet and exercise program. Researchers will compare this approach to a standard heart-healthy maintenance plan in 175 veterans aged 50-75. The goal is to find a practical way to prevent the weight regain that often happens after successful weight loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: intermittent fasting (one day per week, two small meals)
What this could lead to: If it works, this could offer a simple, low-cost way for veterans to keep weight off after losing it, potentially reducing obesity-related health problems.
What could go wrong: This is a small, early-stage study with only 175 participants, and the results may not apply to everyone. Intermittent fasting can be hard to stick with and may cause hunger or low energy.

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Conditions

The condition(s) this trial relates to.

Motor Activity Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVERWEIGHT

Contacts and locations

Locations

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

Baltimore, Maryland, 21201, United States
South Texas Health Care System, San Antonio, TX

San Antonio, Texas, 78229, United States

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