New drug combo aims to supercharge weight loss in obesity trial

NCT ID NCT06643728

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 study tests two drugs, bimagrumab and tirzepatide, alone or together, to see if they help adults with obesity or overweight lose weight safely. About 252 participants without type 2 diabetes will take the drugs or a placebo for up to 70 weeks. The main goal is to measure how much body weight and fat they lose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bimagrumab and tirzepatide (drugs)
What this could lead to: If successful, this could lead to a new combination treatment that helps people with obesity lose more weight and body fat than current options.
What could go wrong: This is an early phase 2 trial with only 252 participants, so results may not apply to everyone. The drugs may cause side effects or not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight platelet-type bleeding disorder 10

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

Locations

Altus Research

Lake Worth, Florida, 33461, United States
Central Research Associates

Birmingham, Alabama, 35205, United States
Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

Jacksonville, Florida, 32256, United States
Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States
East-West Medical Research Institute

Honolulu, Hawaii, 96814, United States
Eastside Research Associates

Redmond, Washington, 98052, United States
Great Lakes Clinical Trials - Ravenswood

Chicago, Illinois, 60640, United States
Keystone Clinical Studies

Plymouth Meeting, Pennsylvania, 19462, United States
Pinnacle Research Group, LLC

Anniston, Alabama, 36207, United States
Rainier Clinical Research Center

Renton, Washington, 98057, United States
SKY Integrative Medical Center/SKYCRNG

Ridgeland, Mississippi, 39157, United States
Suncoast Research Group

Miami, Florida, 33135, United States

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