New obesity drug takes on semaglutide in major trial

NCT ID NCT07668414

Not yet recruiting Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial will test whether a new drug called zenagamtide helps people with obesity lose more weight than the current treatment semaglutide. About 650 adults will receive weekly injections of either zenagamtide, semaglutide, or a placebo. The main goal is to see how much body weight changes over the study period.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zenagamtide
What this could lead to: If it works, this could offer a new weekly injection for weight loss that may be more effective or have fewer side effects than current options.
What could go wrong: This is a Phase 3 trial, but results are not yet known. The drug may not prove better than semaglutide, and side effects like nausea or other issues could limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Amarillo Med Spec LLP

Amarillo, Texas, 79124, United States
Amicis Centers of Clinical Research

St Louis, Missouri, 63128, United States
Artemis Insitute for Clin Res

San Diego, California, 92123, United States
Chicago Research Center, Inc

Chicago, Illinois, 60634, United States
Conquest Research

Atlanta, Georgia, 30328, United States
Desert Oasis Healthcare

Palm Springs, California, 92262, United States
Eastside Bariatric and Gen Surg

Snellville, Georgia, 30078, United States
Encore Medical Research LLC

Hollywood, Florida, 33024, United States
Encore Medical Research of Weston

Weston, Florida, 33331, United States
Endeavor Health

Skokie, Illinois, 60077, United States
Epic Medical Research

DeSoto, Texas, 75115, United States
Essence MD Research

Naples, Florida, 34102, United States
First Valley Medical Group

Lancaster, California, 93534, United States
Florida Inst For Clin Res LLC

Orlando, Florida, 32825, United States
Gastroent Consult of SW VA

Roanoke, Virginia, 24014, United States
Geisinger Clinic

Danville, Pennsylvania, 17822, United States
Hillcrest Clinical Research

Simpsonville, South Carolina, 29681-1538, United States
Houston Research Institute

Houston, Texas, 77079, United States
Ichor Research

Syracuse, New York, 13210, United States
Jacksonville Ctr Clin Res

Jacksonville, Florida, 32216, United States
Lillestol Research LLC

Fargo, North Dakota, 58104, United States
Med Home Development Grp

Washington D.C., District of Columbia, 20037, United States
Medical University Of South Carolina

Charleston, South Carolina, 29425, United States
Midwest Inst For Clin Res

Indianapolis, Indiana, 46260, United States
National Clin Res Inc.

Richmond, Virginia, 23294, United States
NextPhase Research

Hollywood, Florida, 33024, United States
Olympus Clinical Research

Sugar Land, Texas, 77478, United States
Osvaldo A. Brusco MD

Corpus Christi, Texas, 78414, United States
Oviedo Medical Research, LLC

Oviedo, Florida, 32765, United States
Palm Beach Research Center

West Palm Beach, Florida, 33409, United States
PharmQuest Life Sciences LLC

Greensboro, North Carolina, 27408, United States
PharmaDev Clinical Research Institute LLC

Miami, Florida, 33176, United States
Piedmont Healthcare/Research

Statesville, North Carolina, 28625, United States
Pinnacle Clinical Research

Brownsville, Texas, 78520, United States
Rainier Clin Res Ctr Inc

Renton, Washington, 98057, United States
Seattle Clinical Research Center

Seattle, Washington, 98104, United States
Sleep Therapy Research Center

San Antonio, Texas, 78229, United States
South Broward Research LLC

Miramar, Florida, 33027, United States
Southern Clin Research

Zachary, Louisiana, 70791, United States
Southgate Medical Group, LLP

West Seneca, New York, 14224, United States
Spartanburg Medical Research

Spartanburg, South Carolina, 29303, United States
Texas Diabetes & Endocrinology

Austin, Texas, 78749, United States
The Endocrine Center

Houston, Texas, 77079, United States
UT Southwestern Med Center

Dallas, Texas, 75390, United States
University of North Carolina

Chapel Hill, North Carolina, 27514, United States
Western University of Health Sciences

Pomona, California, 91766, United States

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