A daily pill for obesity? zenagamtide faces its biggest test yet.

NCT ID NCT07720271

Not yet recruiting Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether an experimental once-daily oral drug called zenagamtide can safely help people with excess body weight lose weight. Around 950 adults aged 18 and older with overweight or obesity will be randomly assigned to receive either zenagamtide or a placebo tablet each day. The main question is how much body weight changes over the study period, with secondary measures including waist circumference and blood pressure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental once-daily oral drug called zenagamtide
What this could lead to: If it works, this could offer a convenient daily pill for weight loss, potentially helping many people manage obesity.
What could go wrong: This is a phase 3 trial, but the drug is still experimental. It may not prove more effective than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Accellacare and KDCILM, LLC

Wilmington, North Carolina, 28401, United States
Accellacare of Raleigh

Raleigh, North Carolina, 27609, United States
Accellacare-Salisbury PMG Res

Salisbury, North Carolina, 28144, United States
Amarillo Medical Specialists

Amarillo, Texas, 79124, United States
Chambliss Clinical Trials LLC

Montgomery, Alabama, 36106, United States
Clinical Investigation Spec Gurnee

Gurnee, Illinois, 60031, United States
Clinical Neuroscience Solution

Orlando, Florida, 32801, United States
Clinical Res Collaborative

Cumberland, Rhode Island, 02864, United States
Coastal Carolina Research Ctr

North Charleston, South Carolina, 29405, United States
Comprehensive Weight Ctrl Prog

New York, New York, 10021, United States
Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States
ERG Holding Company, LLC / Evolution Research Group, LLC

Delray Beach, Florida, 33445, United States
East West Medical Research Institute_Honolulu

Honolulu, Hawaii, 96814, United States
Endeavor Health

Skokie, Illinois, 60077, United States
Evanston Premier Hlthcr Res

Skokie, Illinois, 60077, United States
Florida Institute for Clinical Research, LLC

Orlando, Florida, 32825, United States
Great Lakes Clinical Trials

Chicago, Illinois, 60640, United States
Health Res of Hampton Roads

Newport News, Virginia, 23606, United States
Hillcrest Clinical Research

Simpsonville, South Carolina, 29681-1538, United States
Hope Clin Res & Wellness

Conyers, Georgia, 30094, United States
Jacksonville Ctr Clin Res

Jacksonville, Florida, 32216, United States
Lynn Institute of Norman

Norman, Oklahoma, 73072, United States
Medical Uni of SC Charleston

Charleston, South Carolina, 29425, United States
Medication Mgmnt, LLC_Grnsboro

Greensboro, North Carolina, 27405, United States
Midwest Inst For Clin Res

Indianapolis, Indiana, 46260, United States
Miguel Rebollar PA

Hialeah, Florida, 33012, United States
National Clin Res Inc.

Richmond, Virginia, 23294, United States
North Texas Endocrine Center

Dallas, Texas, 75231, United States
Northeast Research Institute

Fleming Island, Florida, 32003, United States
Northern Pines Hlth Ctr, PC

Buckley, Michigan, 49620, United States
Oviedo Medical Research, LLC

Oviedo, Florida, 32765, United States
Palm Research Center Inc.

Las Vegas, Nevada, 89128, United States
Pinnacle Research Group LLC

Anniston, Alabama, 36207, United States
Providence Medical Foundation

Fullerton, California, 92835, United States
South Broward Research LLC

Miramar, Florida, 33027, United States
Spartanburg Medical Research

Spartanburg, South Carolina, 29303, United States
StudyMetrix Research LLC

City of Saint Peters, Missouri, 63303, United States
Torrance Clinical Research Institute, Inc.

Lomita, California, 90717, United States
UNC Eastowne Medical Office

Chapel Hill, North Carolina, 27514, United States
Univ of Alabama Birmingham

Birmingham, Alabama, 35294, United States
Univ of Colorado at Denver

Aurora, Colorado, 80045, United States
Washington Cntr Weight Mgmt

Arlington, Virginia, 22206, United States

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