New daily pill could help teens shed pounds in major trial

NCT ID NCT06672939

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 4 times

Summary

This study tests a once-daily pill called orforglipron to help teenagers with obesity or overweight lose weight. About 150 teens will take either the pill or a placebo for 18 months, along with lifestyle advice. The goal is to see if the pill safely reduces body mass index (BMI) and improves quality of life.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

Locations

Addenbrookes Hospital
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Ann & Robert H. Lurie Children's Hospital of Chicago
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
ACTIVE_NOT_RECRUITING

Verona, 37126, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità
ACTIVE_NOT_RECRUITING

Novara, 28100, Italy
Azienda Ospedaliero Universitaria Meyer
ACTIVE_NOT_RECRUITING

Florence, 50139, Italy
Barnsley Hospital NHS Foundation Trust
ACTIVE_NOT_RECRUITING

Barnsley, S75 2EP, United Kingdom
Carey Chronis MD Pediatric, Infant and Adolescent Medicine
ACTIVE_NOT_RECRUITING

Ventura, California, 93003-5369, United States
Children's Healthcare of Atlanta - Center for Advanced Pediatrics
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30329, United States
Childrens Hospital of Pittsburgh
ACTIVE_NOT_RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Dynamed Clinical Research, LP d/b/a DM Clinical Research
ACTIVE_NOT_RECRUITING

Houston, Texas, 77065, United States
FutureMeds - Targowek
ACTIVE_NOT_RECRUITING

Warsaw, 03-291, Poland
FutureMeds sp. z o. o.
ACTIVE_NOT_RECRUITING

Wroclaw, 53-673, Poland
Hull Royal Infirmary
ACTIVE_NOT_RECRUITING

Hull, HU3 2JZ, United Kingdom
Instytut Diabetologii - Warsaw
ACTIVE_NOT_RECRUITING

Warszewo, 2117, Poland
Isesaki Municipal Hospital
RECRUITING

Isesaki-shi, 372-0817, Japan
Krakowskie Centrum Medyczne - FutureMeds
ACTIVE_NOT_RECRUITING

Krakow, 31-501, Poland
La Providence Pediatrics Clinic - Chemidox Clinical Trials
ACTIVE_NOT_RECRUITING

Houston, Texas, 77071-1008, United States
Lucas Research, Inc.
ACTIVE_NOT_RECRUITING

Morehead City, North Carolina, 28557, United States
Martin Diagnostic Clinic
ACTIVE_NOT_RECRUITING

Tomball, Texas, 77375-3332, United States
MedPharmics, LLC
RECRUITING

Gulfport, Mississippi, 39503-2637, United States
Nara Prefecture General Medical Center
RECRUITING

Nara, 630-8054, Japan
Ninewells Hospital
RECRUITING

Dundee, DD1 9SY, United Kingdom
Northwick Park Hospital
RECRUITING

Harrow, HA1 3UJ, United Kingdom
Osaka City General Hospital
RECRUITING

Osaka, 534-0021, Japan
Sagaekiminami Clinic
RECRUITING

Saga, 840-0801, Japan
Saitama Medical University Hospital
RECRUITING

Iruma-Gun, 350-0495, Japan
Shaare Zedek Medical Center
ACTIVE_NOT_RECRUITING

Jerusalem, 9013102, Israel
Shamir Medical Center
ACTIVE_NOT_RECRUITING

Beer Jacob, 73100, Israel
Sheba Medical Center
ACTIVE_NOT_RECRUITING

Ramat Gan, 52621, Israel
Shiga General Hospital
RECRUITING

Moriyama, 524-8524, Japan
Shikoku Medical Center for Children and Adults
RECRUITING

Zentsujichó, 765-8507, Japan
Stamford Therapeutics Consortium
ACTIVE_NOT_RECRUITING

Stamford, Connecticut, 06905, United States
Sundance Clinical Research
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63141-7068, United States
Tokyo Medical Center
RECRUITING

Meguro-Ku, 152-0021, Japan
University Hospital,Kyoto Prefectural University of Medicine
NOT_YET_RECRUITING

Kawaramachidori, Kamigyo-ku, Kyoto-city, 602-8566, Japan
Vanderbilt Health One Hundred Oaks
ACTIVE_NOT_RECRUITING

Nashville, Tennessee, 37212, United States
Velocity Clinical Research
ACTIVE_NOT_RECRUITING

Lafayette, Louisiana, 70508, United States
Velocity Clinical Research, Salt Lake City
RECRUITING

South Jordan, Utah, 84088, United States

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