New drug cocktail aims to tackle obesity epidemic
NCT ID NCT06143956
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial is testing several experimental drugs—including tirzepatide and others—for long-term weight management in adults with obesity or overweight. About 1,481 participants will receive one of the drugs or a placebo. The goal is to see if these treatments are safe and help with weight loss over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tirzepatide, LY3305677, Eloralintide, LY3549492, Macupatide, and placebo
What this could lead to
If successful, this could lead to new, effective weight-loss medications for people with obesity or overweight.
What could go wrong
This is an early Phase 2 trial, so results are uncertain. The drugs may cause side effects or not work better than existing treatments.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
RECRUITINGTroy, Michigan, 48098, United States
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CTI Clinical Research Center
RECRUITINGCincinnati, Ohio, 45212, United States
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Central Washington Health Services Association d/b/a Confluence Health
RECRUITINGWenatchee, Washington, 98801, United States
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Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
RECRUITINGBuenos Aires, C1425AGC, Argentina
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Centro Médico Viamonte
RECRUITINGBuenos Aires, C1120AAC, Argentina
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Centro de Investigaciones Metabólicas (CINME)
RECRUITINGBuenos Aires, C1056ABI, Argentina
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Charter Research - Lady Lake
RECRUITINGThe Villages, Florida, 32162, United States
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Charter Research - Winter Park
RECRUITINGOrlando, Florida, 32803, United States
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Cicemo Srl
RECRUITINGBuenos Aires, 1424, Argentina
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Clinvest Headlands Llc
RECRUITINGSpringfield, Missouri, 65807, United States
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Cotton O'Neil Diabetes & Endocrinology
RECRUITINGTopeka, Kansas, 66606, United States
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Dent Neurologic Institute
RECRUITINGAmherst, New York, 14226, United States
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Diablo Clinical Research, Inc.
RECRUITINGWalnut Creek, California, 94598, United States
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Endeavor Clinical Trials
RECRUITINGSan Antonio, Texas, 78240, United States
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FutureSearch Trials of Dallas
RECRUITINGDallas, Texas, 75251, United States
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Great Lakes Clinical Trials - Ravenswood
RECRUITINGChicago, Illinois, 60640, United States
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HOPE Research Institute
RECRUITINGPhoenix, Arizona, 85032, United States
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Headlands Research - Detroit
RECRUITINGSouthfield, Michigan, 48034, United States
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Headlands Research - Scottsdale
RECRUITINGScottsdale, Arizona, 85260, United States
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IMA Clinical Research Austin
RECRUITINGAustin, Texas, 78745, United States
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Indago Research & Health Center, Inc
RECRUITINGMiami Lakes, Florida, 33016, United States
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Iowa Diabetes and Endocrinology Research Center
RECRUITINGWest Des Moines, Iowa, 50266, United States
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Knownwell
RECRUITINGNeedham, Massachusetts, 02492, United States
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Las Vegas Medical Research
RECRUITINGLas Vegas, Nevada, 89128, United States
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Lucas Research, Inc
RECRUITINGMorehead City, North Carolina, 28557, United States
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Lucas Research, Inc.
RECRUITINGNew Bern, North Carolina, 28562, United States
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Lucida Clinical Trials
RECRUITINGNew Bedford, Massachusetts, 02740, United States
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Medical Research Partners
RECRUITINGAmmon, Idaho, 83406, United States
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Medication Management
RECRUITINGGreensboro, North Carolina, 27405, United States
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Monroe Biomedical Research
RECRUITINGMonroe, North Carolina, 28112, United States
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Monroe Biomedical Research - Louisville
RECRUITINGLouisville, Kentucky, 40213, United States
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New Horizon Research Center
RECRUITINGMiami, Florida, 33165, United States
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NorCal Medical Research, Inc
RECRUITINGGreenbrae, California, 94904, United States
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North Suffolk Neurology
NOT_YET_RECRUITINGPort Jefferson Station, New York, 11776, United States
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NorthShore University Health System
RECRUITINGSkokie, Illinois, 60077, United States
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Northeast Research Institute (NERI)
RECRUITINGFleming Island, Florida, 32003, United States
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Pacific Diabetes & Endocrine Center
NOT_YET_RECRUITINGHonolulu, Hawaii, 96817, United States
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Peninsula Research Associates
RECRUITINGRolling Hills Estates, California, 90274, United States
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PlanIt Research, PLLC
RECRUITINGHouston, Texas, 77079, United States
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Quality Medical Research
RECRUITINGNashville, Tennessee, 37211, United States
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Rochester Clinical Research, LLC
RECRUITINGRochester, New York, 14609, United States
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Sovah Clinical Research-River District
RECRUITINGDanville, Virginia, 24541, United States
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Stamford Therapeutics Consortium
RECRUITINGStamford, Connecticut, 06905, United States
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StudyMetrix Research
RECRUITINGCity of Saint Peters, Missouri, 63303, United States
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Suncoast Clinical Research, Inc.
RECRUITINGNew Port Richey, Florida, 34652, United States
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Tekton Research - Fredericksburg Road
RECRUITINGSan Antonio, Texas, 78258, United States
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Texas Valley Clinical Research
RECRUITINGWeslaco, Texas, 78596, United States
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The Institute for Liver Health II dba Arizona Clinical Trials - Mesa
RECRUITINGChandler, Arizona, 85225, United States
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The Institute for Liver Health II dba Arizona Liver Health-Tucson
RECRUITINGTucson, Arizona, 85712, United States
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Tribe Clinical Research, LLC
RECRUITINGGreenville, South Carolina, 29607, United States
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Velocity Clinical Research, Dallas
RECRUITINGDallas, Texas, 75230, United States
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Velocity Clinical Research, Huntington Park
RECRUITINGHuntington Park, California, 90255, United States
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Velocity Clinical Research, Syracuse
RECRUITINGEast Syracuse, New York, 13057, United States
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