New drug cocktail aims to tackle obesity epidemic

NCT ID NCT06143956

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This Phase 2 trial is testing several experimental drugs—including tirzepatide and others—for long-term weight management in adults with obesity or overweight. About 1,481 participants will receive one of the drugs or a placebo. The goal is to see if these treatments are safe and help with weight loss over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tirzepatide, LY3305677, Eloralintide, LY3549492, Macupatide, and placebo
What this could lead to: If successful, this could lead to new, effective weight-loss medications for people with obesity or overweight.
What could go wrong: This is an early Phase 2 trial, so results are uncertain. The drugs may cause side effects or not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

Locations

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
RECRUITING

Troy, Michigan, 48098, United States
CTI Clinical Research Center
RECRUITING

Cincinnati, Ohio, 45212, United States
Central Washington Health Services Association d/b/a Confluence Health
RECRUITING

Wenatchee, Washington, 98801, United States
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
RECRUITING

Buenos Aires, C1425AGC, Argentina
Centro Médico Viamonte
RECRUITING

Buenos Aires, C1120AAC, Argentina
Centro de Investigaciones Metabólicas (CINME)
RECRUITING

Buenos Aires, C1056ABI, Argentina
Charter Research - Lady Lake
RECRUITING

The Villages, Florida, 32162, United States
Charter Research - Winter Park
RECRUITING

Orlando, Florida, 32803, United States
Cicemo Srl
RECRUITING

Buenos Aires, 1424, Argentina
Clinvest Headlands Llc
RECRUITING

Springfield, Missouri, 65807, United States
Cotton O'Neil Diabetes & Endocrinology
RECRUITING

Topeka, Kansas, 66606, United States
Dent Neurologic Institute
RECRUITING

Amherst, New York, 14226, United States
Diablo Clinical Research, Inc.
RECRUITING

Walnut Creek, California, 94598, United States
Endeavor Clinical Trials
RECRUITING

San Antonio, Texas, 78240, United States
FutureSearch Trials of Dallas
RECRUITING

Dallas, Texas, 75251, United States
Great Lakes Clinical Trials - Ravenswood
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60640, United States
Great Lakes Clinical Trials - Ravenswood
RECRUITING

Chicago, Illinois, 60640, United States
HOPE Research Institute
COMPLETED

Phoenix, Arizona, 85032, United States
Headlands Research - Detroit
RECRUITING

Southfield, Michigan, 48034, United States
Headlands Research - Scottsdale
RECRUITING

Scottsdale, Arizona, 85260, United States
IMA Clinical Research Austin
RECRUITING

Austin, Texas, 78745, United States
Indago Research & Health Center, Inc
RECRUITING

Miami Lakes, Florida, 33016, United States
Iowa Diabetes and Endocrinology Research Center
RECRUITING

West Des Moines, Iowa, 50266, United States
Knownwell
RECRUITING

Needham, Massachusetts, 02492, United States
Las Vegas Medical Research
RECRUITING

Las Vegas, Nevada, 89128, United States
Lucas Research, Inc
RECRUITING

Morehead City, North Carolina, 28557, United States
Lucas Research, Inc.
RECRUITING

New Bern, North Carolina, 28562, United States
Lucida Clinical Trials
RECRUITING

New Bedford, Massachusetts, 02740, United States
Medical Research Partners
RECRUITING

Ammon, Idaho, 83406, United States
Medication Management
RECRUITING

Greensboro, North Carolina, 27405, United States
Monroe Biomedical Research
RECRUITING

Monroe, North Carolina, 28112, United States
Monroe Biomedical Research - Louisville
RECRUITING

Louisville, Kentucky, 40213, United States
New Horizon Research Center
RECRUITING

Miami, Florida, 33165, United States
NorCal Medical Research, Inc
RECRUITING

Greenbrae, California, 94904, United States
North Suffolk Neurology
COMPLETED

Port Jefferson Station, New York, 11776, United States
NorthShore University Health System
ACTIVE_NOT_RECRUITING

Skokie, Illinois, 60077, United States
Northeast Research Institute (NERI)
COMPLETED

Fleming Island, Florida, 32003, United States
Pacific Diabetes & Endocrine Center
COMPLETED

Honolulu, Hawaii, 96817, United States
Peninsula Research Associates
RECRUITING

Rolling Hills Estates, California, 90274, United States
PlanIt Research, PLLC
RECRUITING

Houston, Texas, 77079, United States
Quality Medical Research
RECRUITING

Nashville, Tennessee, 37211, United States
Rochester Clinical Research, LLC
RECRUITING

Rochester, New York, 14609, United States
Sovah Clinical Research-River District
RECRUITING

Danville, Virginia, 24541, United States
Stamford Therapeutics Consortium
RECRUITING

Stamford, Connecticut, 06905, United States
StudyMetrix Research
RECRUITING

City of Saint Peters, Missouri, 63303, United States
Suncoast Clinical Research, Inc.
RECRUITING

New Port Richey, Florida, 34652, United States
Tekton Research - Fredericksburg Road
COMPLETED

San Antonio, Texas, 78258, United States
Texas Valley Clinical Research
RECRUITING

Weslaco, Texas, 78596, United States
The Institute for Liver Health II dba Arizona Clinical Trials - Mesa
RECRUITING

Chandler, Arizona, 85225, United States
The Institute for Liver Health II dba Arizona Liver Health-Tucson
RECRUITING

Tucson, Arizona, 85712, United States
Tribe Clinical Research, LLC
RECRUITING

Greenville, South Carolina, 29607, United States
Velocity Clinical Research, Dallas
RECRUITING

Dallas, Texas, 75230, United States
Velocity Clinical Research, Huntington Park
RECRUITING

Huntington Park, California, 90255, United States
Velocity Clinical Research, Syracuse
RECRUITING

East Syracuse, New York, 13057, United States

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