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New drug combo aims to tackle obesity in major trial

NCT ID NCT07589608

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2b trial is testing whether two experimental drugs, macupatide and eloralintide, can help adults with obesity or overweight lose weight. About 400 participants will receive either one or both drugs or a placebo for 64 weeks. The study measures weight change and safety, excluding people with diabetes or certain heart conditions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

macupatide and eloralintide (injectable drugs)

What this could lead to

If successful, this could lead to a new combination treatment for significant weight loss in people with obesity or overweight.

What could go wrong

This is a Phase 2 trial, so it's still early. The drugs may not work better than placebo, or they could have side effects like heart rhythm issues or pancreatitis.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    RECRUITING

    Troy, Michigan, 48098, United States

    Contact

  • CTI Clinical Research Center

    RECRUITING

    Cincinnati, Ohio, 45212, United States

    Contact

  • Central Washington Health Services Association d/b/a Confluence Health

    RECRUITING

    Wenatchee, Washington, 98801, United States

    Contact

  • Charter Research - Lady Lake

    RECRUITING

    The Villages, Florida, 32162, United States

    Contact

  • Charter Research - Winter Park

    RECRUITING

    Orlando, Florida, 32803, United States

    Contact

  • Clinvest Headlands Llc

    RECRUITING

    Springfield, Missouri, 65807, United States

    Contact

  • Cotton O'Neil Diabetes & Endocrinology

    RECRUITING

    Topeka, Kansas, 66606, United States

    Contact

  • Dent Neurologic Institute

    RECRUITING

    Amherst, New York, 14226, United States

    Contact

  • Diablo Clinical Research, Inc.

    RECRUITING

    Walnut Creek, California, 94598, United States

    Contact

  • Endeavor Clinical Trials

    RECRUITING

    San Antonio, Texas, 78240, United States

    Contact

  • FutureSearch Trials of Dallas

    RECRUITING

    Dallas, Texas, 75251, United States

    Contact

  • Great Lakes Clinical Trials - Ravenswood

    RECRUITING

    Chicago, Illinois, 60640, United States

    Contact

  • Headlands Research - Detroit

    RECRUITING

    Southfield, Michigan, 48034, United States

    Contact

  • Headlands Research - Scottsdale

    RECRUITING

    Scottsdale, Arizona, 85260, United States

    Contact

  • IMA Clinical Research Austin

    RECRUITING

    Austin, Texas, 78745, United States

    Contact

  • Indago Research & Health Center, Inc

    RECRUITING

    Miami Lakes, Florida, 33016, United States

    Contact

  • Knownwell

    RECRUITING

    Needham, Massachusetts, 02492, United States

    Contact

  • Las Vegas Medical Research

    RECRUITING

    Las Vegas, Nevada, 89128, United States

    Contact

  • Lucas Research, Inc

    RECRUITING

    Morehead City, North Carolina, 28557, United States

    Contact

  • Lucas Research, Inc.

    RECRUITING

    New Bern, North Carolina, 28562, United States

    Contact

  • Lucida Clinical Trials

    RECRUITING

    New Bedford, Massachusetts, 02740, United States

    Contact

  • Medical Research Partners

    RECRUITING

    Ammon, Idaho, 83406, United States

    Contact

  • Medication Management

    RECRUITING

    Greensboro, North Carolina, 27405, United States

    Contact

  • Monroe Biomedical Research

    RECRUITING

    Monroe, North Carolina, 28112, United States

    Contact

  • Monroe Biomedical Research - Louisville

    RECRUITING

    Louisville, Kentucky, 40213, United States

    Contact

  • New Horizon Research Center

    RECRUITING

    Miami, Florida, 33165, United States

    Contact

  • NorCal Medical Research, Inc

    RECRUITING

    Greenbrae, California, 94904, United States

    Contact

  • Peninsula Research Associates

    RECRUITING

    Rolling Hills Estates, California, 90274, United States

    Contact

  • PlanIt Research, PLLC

    RECRUITING

    Houston, Texas, 77079, United States

    Contact

  • Quality Medical Research

    RECRUITING

    Nashville, Tennessee, 37211, United States

    Contact

  • Rochester Clinical Research, LLC

    RECRUITING

    Rochester, New York, 14609, United States

    Contact

  • Sovah Clinical Research-River District

    RECRUITING

    Danville, Virginia, 24541, United States

    Contact

  • Stamford Therapeutics Consortium

    RECRUITING

    Stamford, Connecticut, 06905, United States

    Contact

  • StudyMetrix Research

    RECRUITING

    City of Saint Peters, Missouri, 63303, United States

    Contact

  • Suncoast Clinical Research, Inc.

    RECRUITING

    New Port Richey, Florida, 34652, United States

    Contact

  • Texas Valley Clinical Research

    RECRUITING

    Weslaco, Texas, 78596, United States

    Contact

  • The Institute for Liver Health II dba Arizona Clinical Trials - Mesa

    RECRUITING

    Chandler, Arizona, 85225, United States

    Contact

  • The Institute for Liver Health II dba Arizona Liver Health-Tucson

    RECRUITING

    Tucson, Arizona, 85712, United States

    Contact

  • Tribe Clinical Research, LLC

    RECRUITING

    Greenville, South Carolina, 29607, United States

    Contact

  • Velocity Clinical Research, Huntington Park

    RECRUITING

    Huntington Park, California, 90255, United States

    Contact