New drug combo aims to shed pounds and control diabetes

NCT ID NCT07215559

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 5 times

Summary

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will receive the drugs or a placebo for 48 weeks. The main goal is to see how much weight they lose and how their blood sugar changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: macupatide and eloralintide (drugs)
What this could lead to: If successful, this could lead to a new treatment option for weight loss in people with obesity and type 2 diabetes, potentially improving blood sugar control.
What could go wrong: This is an early phase 2 trial with only 200 participants, so results may not apply to everyone. The drugs may cause side effects or fail to show significant weight loss compared to placebo.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2 OBESITY OVERWEIGHT

Contacts and locations

Locations

AGILE Clinical Research Trials, LLC
RECRUITING

Sandy Springs, Georgia, 30328, United States
AIM Research
COMPLETED

Merewether, 2291, Australia
Aavon Clinical Trials
RECRUITING

Richmond, Texas, 77407, United States
Biopharma Informatic, LLC
RECRUITING

Houston, Texas, 77043, United States
CDH Research Institute Pty Ltd
RECRUITING

Maroochydore, 4558, Australia
CEDIC
RECRUITING

CABA, C1060ABN, Argentina
CENUDIAB
RECRUITING

Buenos Aires, C1440AAD, Argentina
Centro de Investigaciones Metabólicas (CINME)
RECRUITING

Buenos Aires, C1056ABI, Argentina
Clinical Research Partners, LLC
RECRUITING

Richmond, Virginia, 23226, United States
Clínica Universitaria Reina Fabiola
RECRUITING

Córdoba, X50004FHP, Argentina
Consano Clinical Research, LLC
RECRUITING

Shavano Park, Texas, 78231, United States
Core Research Group
RECRUITING

Brisbane, 4064, Australia
Cornerstone Dermatology
RECRUITING

Coorparoo, 4151, Australia
Eastern Virginia Medical School (EVMS) Medical Group
RECRUITING

Norfolk, Virginia, 23510, United States
Emeritus Research
RECRUITING

Botany, 2019, Australia
Emeritus Research
RECRUITING

Camberwell, 3124, Australia
Go Centro Medico San Nicolás
RECRUITING

San Nicolás, 2900, Argentina
Instituto de Investigaciones Clínicas Córdoba
RECRUITING

Córdoba, 5000, Argentina
Kalo Clinical Research
RECRUITING

West Valley City, Utah, 84120, United States
Mercy Family Clinic
RECRUITING

Dallas, Texas, 75208, United States
Mgcendo Llc
RECRUITING

San Juan, 00921, Puerto Rico
Momentum Darlinghurst
RECRUITING

Darlinghurst, Sydney, 2010, Australia
Momentum Sunshine
RECRUITING

Melbourne, 3021, Australia
Northwest Clinical Research Center
RECRUITING

Bellevue, Washington, 98007, United States
Pima Heart
RECRUITING

Tucson, Arizona, 85741, United States
Pivotal Research Solutions
RECRUITING

Stonecrest, Georgia, 30038, United States
PlanIt Research, PLLC
RECRUITING

Houston, Texas, 77079, United States
Precision Clinical Research
RECRUITING

Sunrise, Florida, 33351, United States
Premier Research
RECRUITING

Trenton, New Jersey, 08611, United States
PriMED Clinical Research
RECRUITING

Dayton, Ohio, 45429, United States
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
RECRUITING

Gilbert, Arizona, 85296, United States
Rainier Clinical Research Center
RECRUITING

Renton, Washington, 98057, United States
Research Physicians Network, LLC
RECRUITING

Houston, Texas, 77089, United States
Rophe Adult and Pediatric Medicine/SKYCRNG
RECRUITING

Union City, Georgia, 30291, United States
SKY Clinical Research Network Group-Brown
RECRUITING

Atlanta, Georgia, 30331, United States
San Juan Bautista School of Medicine - Clinical Research Unit
RECRUITING

Caguas, 00726, Puerto Rico
Synexus Clinical Research US, Inc.
RECRUITING

Phoenix, Arizona, 85020, United States
Teak Research Consults
RECRUITING

Lawrenceville, Georgia, 30043, United States
Texas Valley Clinical Research
RECRUITING

Weslaco, Texas, 78596, United States
Universal Research Group
RECRUITING

Tacoma, Washington, 98405, United States
Vector Clinical Trials
RECRUITING

Las Vegas, Nevada, 89128, United States
Velocity Clinical Research, Dallas
RECRUITING

Dallas, Texas, 75230, United States

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