Could your diet soda change how your medicine works?

NCT ID NCT03407079

Recruiting now Knowledge-focused Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether the artificial sweetener sucralose (found in many diet drinks and foods) changes how the body absorbs and processes certain medications. Researchers will give 150 healthy, overweight Black and Hispanic women either sucralose or a placebo capsule for 28 days. They will measure drug levels, hormone changes, gut bacteria, and fat cell activity to see if sucralose has any effect.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sucralose
What this could lead to: If it works, this could help doctors understand whether artificial sweeteners like sucralose change how medications work in the body.
What could go wrong: This is a small, early-phase study in healthy volunteers, so results may not apply to people with medical conditions or those taking long-term medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY VOLUNTEERS OVERWEIGHT

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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