National Institute On Alcohol Abuse And Alcoholism (niaaa)

This early-stage study is testing whether a cholesterol-lowering drug called alirocumab is safe and well-tolerated in adults who are heavy drinkers. Researchers also want to see if the drug can reduce signs of liver inflammation and damage caused by alcohol. The study involves 10…

This study aims to better understand alcohol use problems by observing a large group of people over time. It will enroll up to 7,500 adults, including those with alcohol problems (whether they want treatment or not) and healthy volunteers. Researchers will collect detailed health…

This study aims to find out if consuming the artificial sweetener sucralose changes how the body absorbs and processes certain medications. Researchers are enrolling 150 overweight or obese Black and Hispanic women to take either sucralose or a placebo pill for a month. They will…

This study aims to develop and test simple computer tasks that can be used during brain scans to better understand how alcohol use disorders affect behavior, thinking, and decision-making. Researchers are recruiting 400 adults, including both healthy volunteers and people with al…

This study aims to understand how an existing medication for alcohol use disorder (acamprosate) affects brain function. Researchers will measure brain activity using EEG caps in 48 adults with moderate to severe alcohol use disorder. Half will receive the real medication and half…

This study aims to understand why some people might be more vulnerable to developing alcohol problems by looking at a specific gene called ZIP8. Healthy volunteers who drink alcohol but do not have an alcohol use disorder will receive controlled alcohol infusions and have their b…

This study aims to understand how a specific gene related to nicotine receptors influences a person's brain activity and behavior when exposed to alcohol. Researchers will recruit 128 healthy adults, including both smokers and non-smokers, to undergo brain scans and controlled al…

This study aims to understand how alcohol use disorder changes the brain. Researchers will use MRI brain scans and computer games to compare brain structure and function in adults with and without alcohol dependence. The goal is to link these brain differences to behavior, person…

This research aims to develop better brain scanning methods to study how addiction affects the brain. Healthy adult volunteers will undergo MRI scans while performing simple tasks to help researchers measure brain activity and structure. The goal is to create improved tools for f…

This study aims to understand how alcohol use disorder affects people's senses of taste and smell. Researchers will compare 475 adults with and without alcohol use disorder through taste tests, smell assessments, brain scans, and sample collection. The goal is to identify biologi…

This study aims to understand how the stress and isolation of the COVID-19 pandemic have affected people's alcohol use and related problems over time. Researchers will follow 1,500 participants for two years, asking them to complete regular surveys about their drinking, stress le…

This study is investigating whether suvorexant, a medication approved for sleep problems, can change brain chemistry related to addiction in people with alcohol use disorder (AUD). Researchers will compare brain scans, sleep patterns, and cravings in people with AUD receiving eit…