National Institute On Alcohol Abuse And Alcoholism (niaaa)

This study tests whether a drug called apremilast can help people with moderate to severe alcohol use disorder drink less. About 100 adults will take either a low dose, a high dose, or a placebo pill daily for several weeks. Researchers will measure cravings, drinking habits, and…

This study tests whether tirzepatide, a drug already approved for weight management, can help people with alcohol use disorder and related liver disease drink less and improve liver health. About 120 adults aged 21 and older will receive weekly injections of tirzepatide or a plac…

This study explores whether suvorexant, a drug used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. Researchers will compare suvorexant to a placebo in 180 adults (ages 18-75) with AUD who are undergoing detox…

This study aims to develop better brain imaging techniques, like MRI and EEG, to understand how addiction affects the brain. Healthy adults aged 18 and older will undergo scans and simple tasks to help researchers improve these methods. The goal is to create reliable tools for fu…

This study is gathering information from up to 7,500 adults, including those with alcohol use disorder who want treatment, those who don't, and healthy volunteers. Researchers will collect medical history, blood samples, and brain scans to better understand the condition. The goa…

This study looks at how the drug acamprosate changes brain activity in people with moderate to severe alcohol use disorder. Researchers will use EEG to measure brain waves in 48 adults who stay in the clinic for about 3 weeks. Half get the drug, half get a placebo, and the goal i…

This early-stage study tests whether alirocumab, a drug used for high cholesterol, is safe and may reduce liver inflammation in heavy drinkers. About 100 healthy adults who drink 20+ alcoholic beverages per week will receive either the drug or a placebo injection for 8 weeks. Res…

This study looks at how a gene called ZIP8 might affect why some people are more likely to develop alcohol use disorder. Researchers will give alcohol through an IV to healthy volunteers and measure how much they choose to drink. They will also scan participants' brains to see ho…

This study looks at how alcohol use disorder (AUD) affects a person's sense of taste and smell. Researchers will compare people with and without AUD using taste tests, smell tests, and brain scans. The goal is to understand the link between alcohol drinking and sensory changes. N…

This study looks at whether the artificial sweetener sucralose (found in many diet foods and drinks) affects how the body absorbs and breaks down certain medicines. Researchers will give healthy, overweight Black and Hispanic women either sucralose or a placebo for four weeks and…

This study follows 1500 adults to understand how the COVID-19 pandemic has changed their drinking habits and stress levels. Participants complete surveys online or by phone over 2 years, reporting on alcohol use, mental health, and quality of life. No treatments or medications ar…

This study aims to understand how the brains of people with alcohol dependence differ from those without it. Researchers will use MRI scans and computer games to look at brain structure and activity. About 1,000 adults aged 18 and older will participate in a single visit. No trea…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with alcohol use disorders. Researchers will use MRI scans to see how the brain works during these tasks. The goal is to develop reliable tools for future studies, not…

This study looks at how a specific gene (CHRNA5) might influence how people experience alcohol and how their brains respond to alcohol-related cues. Healthy adults aged 21-60, both smokers and non-smokers, will receive alcohol through an IV or drink it while researchers monitor t…