National Institute On Alcohol Abuse And Alcoholism (niaaa)

This completed study looked at how opioid use disorder changes dopamine signaling in the brain. Researchers used PET and MRI scans to compare people with opioid use disorder (some on medication, some not) to healthy volunteers. The goal was to understand differences in dopamine r…

This study looked at whether sleep helps the brain clear out a waste product called amyloid-beta, which is linked to Alzheimer's disease. Twenty-two healthy adults had brain scans after a full night's sleep and after being kept awake all night. The goal was to see if sleep affect…

This study looks at how drinking alcohol changes the way people make decisions about risky sexual behavior, which could lead to HIV. Twenty healthy adults aged 21-65 will have two visits: one where they drink alcohol and one where they drink a placebo. During brain scans, they wi…

This study used MRI scans to see if the brain removes waste more actively during sleep than when awake. Forty healthy adults were scanned after a good night's rest and after sleep deprivation. The goal was to measure differences in water movement in the brain, which may reflect t…

This study looked at how consistent brain scans are when repeated in healthy adults. 112 volunteers had MRI and PET scans to measure brain connections and activity. The goal was to improve future research on brain diseases by understanding normal brain function and scan reliabili…

This study used brain scans to see if heavy drinking causes inflammation in the brain and how that affects memory and thinking. 74 adults aged 30-75, including heavy drinkers and healthy volunteers, had PET and MRI scans along with thinking tests. The goal was to measure brain in…

This study tested a computer-assisted method for people to self-administer alcohol intravenously, aiming to achieve precise blood alcohol levels for research. 229 healthy volunteers aged 21-45 took part in sessions where they could give themselves alcohol infusions using a comput…

This study looked at how nalmefene, a drug that blocks opioid receptors, changes brain activity and drinking behavior in heavy drinkers. Thirteen healthy heavy drinkers took nalmefene or a placebo and had brain scans while seeing alcohol-related cues. They also could self-adminis…

This study looked at whether people with alcohol dependence or a history of early life stress have more trouble learning to feel calm after a scary event. Researchers used brain scans, mild electric shocks, and genetic tests to understand these differences. The goal was to learn …