National Institute On Alcohol Abuse And Alcoholism (niaaa)

This study looked at how sleep affects the brain's ability to clear out waste products, specifically amyloid-beta, which is linked to Alzheimer's disease. Twenty-two healthy adults stayed overnight in a clinic twice—once sleeping normally and once staying awake all night. Researc…

This study used MRI scans to see if the brain removes waste more effectively during sleep than when awake. Forty healthy adults aged 18 to 60 were monitored while sleeping or staying awake inside the scanner. The goal was to understand the glymphatic system, which helps clear har…

This study looked at how heavy opioid use changes dopamine, a brain chemical that affects pleasure and self-control. Researchers compared people with opioid use disorder (some on medication, some not) to healthy volunteers. They used brain scans and thinking tests to understand t…

This study tested whether nalmefene, a drug that blocks opioid receptors, changes how heavy drinkers' brains respond to alcohol-related cues and how much alcohol they choose to take. Thirteen healthy heavy drinkers (ages 21-60) participated. They received nalmefene or a placebo, …

This study looked at how consistent brain scans are when measuring connections between different brain regions. Researchers scanned 112 healthy adults twice on the same day using MRI and also used PET scans to measure brain activity. The goal was to understand normal brain functi…

This study tested a computer-assisted method for giving alcohol directly into the bloodstream through a vein, aiming to achieve precise blood alcohol levels for research. 229 healthy adults aged 21-45 who were social drinkers took part. Participants used a computer to self-admini…

This study looked at whether heavy drinking causes brain inflammation and affects memory, attention, and thinking. Researchers used brain scans (PET and MRI) to compare people with alcohol use disorder to healthy volunteers. The goal was to understand how inflammation changes wit…

This study looked at how alcohol dependence and early life stress (ELS) affect a person's ability to learn to feel calm after fear. Researchers compared 96 adults with and without alcohol use disorder and with and without ELS. Participants underwent brain scans, mild electric sho…