Gene linked to nicotine may explain why some people crave alcohol more
NCT ID NCT03294460
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This study looks at how a specific nicotine receptor gene (CHRNA5) influences people's response to alcohol. Healthy adults aged 21-60, both smokers and non-smokers, will receive alcohol through an IV or drink it, while researchers measure their brain activity using MRI and track their drinking behavior. The goal is to understand why some people are more prone to alcohol use disorder.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Alcohol (oral and intravenous)
What this could lead to
If successful, this study could help explain why some people are more vulnerable to alcohol use disorder based on their genes, potentially guiding future prevention or treatment strategies.
What could go wrong
This is an early-phase, observational study with a small sample size. It does not test a treatment, so direct benefits are unlikely. Results may not apply to everyone.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••