ALCOHOL DRINKING

This study tests an adaptive web-based program called Partners Connect for military couples. It aims to reduce drinking in concerned partners and encourage service members to seek help for alcohol use. About 744 couples will be assigned to either the online program or standard we…

This study tests a program to help pregnant women cut down on alcohol. About 600 women who are 28 weeks or less along and have had alcohol recently will take part. The program includes a computer lesson and talks with a nurse to boost motivation. The goal is to see if this leads …

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can reduce the urge to drink alcohol and lower heavy drinking days. About 86 adults with alcohol use disorder will receive either real or sham TBS over the front part of …

This study tests whether a smartphone chatbot that uses motivational interviewing can help high-risk drinkers reduce their alcohol intake. About 220 adults who want to drink less will use the app for four weeks, and their drinking will be compared to a control group. The goal is …

This study tests a phone-based therapy called Acceptance and Commitment Therapy (ACT) to help people with HIV who drink too much. Researchers will compare ACT to a standard brief intervention in 300 adults. The goal is to see if ACT reduces alcohol use and improves symptoms of de…

This study checks if a short questionnaire called T-ACE can correctly identify pregnant women who may be drinking alcohol at risky levels. Researchers will compare the questionnaire results with a blood test that measures alcohol use over the past three weeks. About 2,425 pregnan…

This study tests a prevention program for binge drinking in 240 young adults aged 18-30. The program combines motivational interviewing with social psychology methods to change drinking habits. Participants will be followed to see if their binge drinking score improves.

This study looks at two ways to help young people ages 12-19 who already drink alcohol to cut back. One group gets a short web program, and the other gets that plus supportive text messages for 8 weeks. Parents can also use a free app to talk with their kids about drinking. The g…

This study looks at whether adding well-timed text messages to a standard alcohol education program can help prevent binge drinking and related trouble (like DUIs) in about 3,000 US Air Force technical trainees. Participants will either get the usual program or the usual program …

This study looks at whether a single dose of a nutritional ketone ester drink can change how the brain responds to alcohol cues and reduce the urge to drink in people with alcohol use disorder. Twenty adults who drink heavily but are not seeking treatment will receive either the …

This study tests whether watching a short, flickering video (called dynamic visual noise) can reduce alcohol cravings and drinking in college students who crave alcohol at least once a week. Participants will watch either the flickering video or a still image daily for seven days…

This study is testing a computer program that uses interactive stories and artificial intelligence to help teenagers aged 15-17 who already drink alcohol make healthier choices. About 200 teens will use the program during their regular clinic visits. The goal is to see if the pro…

This study explores how binge drinking affects blood pressure and small blood vessels in adults aged 50-64. Researchers will compare binge drinkers to non-drinkers and moderate drinkers. Then, they will test whether 8 weeks of aerobic exercise can improve blood pressure and blood…

This study looks at why young adults with bipolar disorder are much more likely to develop alcohol use disorders. Researchers will track 100 people aged 21-26 (half with bipolar disorder, half without) for two years, using brain scans and alcohol response tests. The goal is to fi…

This study looks at how having PTSD might change the way people make decisions after drinking alcohol. Researchers want to understand why some people with PTSD develop alcohol problems. They will give 200 adults either alcohol or a placebo and use brain scans to see how their bra…

This study looks at how alcohol, cannabis, and certain medications affect falls and thinking in people with HIV. Researchers will test if a talk with a pharmacist can help. One hundred people with HIV who drink alcohol and take multiple medications will take part.

This study looks at how a single dose of a ketone drink or alcohol affects brain chemistry using MRI scans. Sixty adults who drink alcohol occasionally will each have three separate MRI visits: after a ketone drink, after an alcoholic drink, and with no drink. The goal is to meas…

This pilot study looks at whether reducing alcohol and taking probiotics can boost memory and brain function in healthy older adults (ages 65-84) who drink heavily. Participants will get counseling to cut back on drinking and will take either a probiotic or a placebo pill. The st…

This study follows 1500 adults to understand how the COVID-19 pandemic has changed their drinking habits and stress levels. Participants complete surveys online or by phone over 2 years, reporting on alcohol use, mental health, and quality of life. No treatments or medications ar…

This study aims to understand how the brains of people with alcohol dependence differ from those without it. Researchers will use MRI scans and computer games to look at brain structure and activity. About 1,000 adults aged 18 and older will participate in a single visit. No trea…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with alcohol use disorders. Researchers will use MRI scans to see how the brain works during these tasks. The goal is to develop reliable tools for future studies, not…

This study looks at whether teaching people how to step in during sexual risk situations works better when combined with a program to reduce drinking. About 450 heavy drinkers aged 18-25 will be split into three groups: bystander training alone, bystander training plus alcohol re…

This study looks at how a specific gene (CHRNA5) might influence how people experience alcohol and how their brains respond to alcohol-related cues. Healthy adults aged 21-60, both smokers and non-smokers, will receive alcohol through an IV or drink it while researchers monitor t…