ALCOHOL DRINKING

This study tests whether a 30-day alcohol abstinence challenge, supported by a mobile app, is feasible and helps reduce heavy drinking. Researchers will enroll 150 adults in Oklahoma who drink regularly. Participants will try to completely avoid alcohol for one month, and the stu…

This study tests a smartphone app designed to help young adults aged 18 to 25 who want to reduce their combined use of alcohol and opioids. The app sends timely tips based on users' daily reports. The goal is to see if the app is usable, satisfying, and worth testing in larger st…

This study tests an adaptive web-based program called Partners Connect for military couples. It aims to reduce drinking in concerned partners and encourage service members to seek help for alcohol use. About 744 couples will participate, comparing the online program to standard w…

This study is testing whether a type of brain stimulation called theta burst stimulation (TBS) can reduce heavy drinking and cravings in people with alcohol use disorder. Researchers will apply magnetic pulses to a brain region linked to drinking patterns, comparing real stimulat…

This study tests whether a single dose of a ketone ester drink can reduce alcohol cravings and consumption in people with alcohol use disorder. Twenty non-treatment-seeking participants will receive either the ketone drink or a placebo on two separate days, then undergo brain sca…

This study tests a phone-based therapy called Acceptance and Commitment Therapy (ACT) to help people with HIV who drink heavily. The goal is to reduce alcohol use and improve symptoms of depression and anxiety. 300 participants will be randomly assigned to ACT or a standard brief…

This pilot study tests a program where a clinical pharmacist talks with people with HIV about the risks of drinking alcohol (with or without cannabis) while taking multiple medications, especially those that affect the brain. The goal is to see if this approach can reduce falls a…

This study tests whether using mobile health (mHealth) tools helps find early signs of oral cancer better than the usual visual exam in rural areas of Varanasi, India. Over 5,000 adults with risk factors like smoking, tobacco use, or age over 40 will be screened. The goal is to c…

This study is checking whether a short self-report questionnaire called T-ACE can accurately identify pregnant women who drink alcohol at high-risk levels. About 2,425 pregnant women in three French hospitals will fill out the questionnaire and then give a blood sample to measure…

This study tests whether well-timed text messages can help young Air Force trainees avoid binge drinking and its consequences. About 7,000 trainees will either get the standard alcohol intervention or that plus automated texts sent just before, during, and after they first get ac…

This study tests whether a motivational interviewing program delivered over Zoom can increase bystander intervention in sexual risk situations and reduce alcohol use among heavy-drinking young adults aged 18-25. 450 participants will be assigned to one of three groups: a bystande…

This study tests a motivational program to help pregnant women reduce alcohol use. About 600 pregnant women who drink alcohol will either receive the program (computer-based lessons plus nurse support) or standard prenatal care. The goal is to see if the program leads to more wom…

This study tests a prevention program for binge drinking in 240 students aged 18-30. The program combines motivational interviewing with social psychology techniques to change drinking habits. Researchers will measure changes in binge drinking scores and readiness to change. The …

This study tests two digital programs to prevent or reduce alcohol misuse in teens aged 12-19 who have used alcohol in the past year. Participants receive a brief web program, and some also get 8 weeks of supportive text messages. Parents are encouraged to use a free app to guide…

This study tests a program that combines a smartphone breathalyzer, a blood alcohol estimator app, and a brief counseling session to help young adults who drink heavily. Researchers want to see if these tools are easy to use and helpful for drinking more moderately. The study inv…

This study tests whether a friendly chatbot app can help high-risk drinkers reduce their alcohol intake. About 220 adults who want to drink less will use the app for four weeks, and researchers will check their drinking habits at 4 and 16 weeks. The goal is to see if the app's mo…

This study tests whether watching a short video of flickering black and white squares (called Dynamic Visual Noise) can reduce alcohol cravings and drinking in young adults who drink weekly. 62 college students will either watch the flickering video or a still image every day for…

This study looks at how a specific nicotine receptor gene (CHRNA5) influences people's response to alcohol. Healthy adults aged 21-60, both smokers and non-smokers, will receive alcohol through an IV or drink it, while researchers measure their brain activity using MRI and track …

This study is creating and testing simple computer tasks that can be done inside an MRI scanner to measure brain activity related to behavior. Researchers want to better understand how alcohol use disorder affects the brain. The study involves up to 400 healthy volunteers and peo…

This study looks at how stress from stereotypes affects impulsivity and alcohol use in African Americans. Researchers will use fMRI brain scans to measure brain activity while participants do tasks that involve everyday stress. The goal is to understand the link between social st…

This observational study uses brain scans (MRI) and behavioral tasks to compare people with and without alcohol dependence. Researchers want to see if differences in brain structure and activity relate to personality, behavior, and genetics. Up to 1,000 adults will participate in…

This study tracks 1,500 people over two years to see how the COVID-19 pandemic has changed their drinking habits and related stress. Participants complete surveys about alcohol use, stress, and well-being, comparing before and during the pandemic. The goal is to understand the pa…

This study looks at how binge drinking in mid-life (ages 50-64) affects blood pressure, small blood vessels, and nerve activity. It compares binge drinkers to non-drinkers and moderate drinkers. In a second phase, binge drinkers will try 8 weeks of aerobic exercise to see if it i…

This study tests whether a 4-week ketogenic diet changes how the brain responds to alcohol. Twenty adults will follow the diet and undergo alcohol tolerance tests and brain scans before, during, and after the diet. The goal is to understand how ketosis affects alcohol metabolism …

This study aims to see how Jägerbombs (a mix of energy drink and alcohol) affect young adults differently than drinking alcohol alone during a binge-drinking session. Researchers will measure reaction time, coordination, vision, stress hormones, and hangover symptoms in 24 health…

This study looks at how alcohol changes decision-making in people with PTSD, especially when they have to choose between reward and danger. Researchers will give participants either alcohol or a placebo and then scan their brains while they perform a task. The goal is to understa…

This study looks at how a single dose of a ketone supplement or an alcoholic drink changes brain metabolism compared to no drink. Sixty healthy adults who drink occasionally will have three MRI scans after each condition. The goal is to measure brain chemicals like NAD, glutamate…

This pilot study tests whether a combination of reducing alcohol and taking a probiotic supplement can improve thinking skills and brain metabolism in healthy older adults (ages 65-84) who are heavy drinkers. Twenty participants will receive either a probiotic or a placebo for 30…

This study looks at why young adults with bipolar disorder are much more likely to develop alcohol use disorders. Researchers will give participants alcohol or a placebo and use brain scans to track changes over two years. The goal is to find early warning signs that could lead t…

This study is testing a web-based tool called ChangeGradients that uses machine learning to create personalized stories for teens who drink alcohol. The goal is to help them understand the risks and make healthier choices. Researchers are recruiting 200 adolescents aged 15-17 who…