ALCOHOL DRINKING

This study tests a digital program designed to help young adults (ages 18-28) who are not in college and live in disadvantaged communities reduce risky drinking. The program combines a brief motivational interview with a session that encourages engagement in enjoyable, alcohol-fr…

This small pilot study tested whether propranolol, a beta blocker usually used for high blood pressure, can reduce alcohol drinking triggered by stress. Twenty adults with alcohol use disorder were randomly assigned to take propranolol or a placebo for about two weeks, then compl…

This study tests different ways to help people drink less alcohol before and after elective surgery. The goal is to improve surgical outcomes and long-term health. About 440 adults scheduled for major non-cancer surgery are taking part.

This study tests a phone-based care management program for adults with depression, anxiety, or risky drinking. Participants get regular check-ins and support from a mental health technician, while their primary care doctor receives treatment recommendations. The goal is to see if…

This study tests whether online mindfulness-based relapse prevention (MBRP) helps people with alcohol use disorder maintain long-term recovery. About 470 adults who recently sought treatment or tried to cut back on drinking will either join MBRP video groups or be referred to onl…

This study tests a program called Journey of Transformation for Native American tenth graders at an off-reservation boarding school. The program uses traditional storytelling, cultural arts, and outdoor activities to teach leadership and healthy decision-making around substance u…

This study tests whether a brief 10-20 minute motivational interview given to injured patients who drink heavily can reduce future harm. Researchers will track hospital readmissions, DUIs, and drinking behavior over 12 months in 830 adults. The goal is to see if a simple conversa…

This study tests whether adding trauma-informed coping strategies and peer coaching to a standard mobile brief intervention helps young adults (ages 18-25) who drink heavily and have experienced interpersonal trauma reduce their alcohol use. 225 college students will be randomly …

This study is testing a new program called mSTARS for people who drink heavily and have been hospitalized for a suicide crisis. The program combines in-hospital therapy with a smartphone app to help manage emotions after leaving. Ten participants will try the program and give fee…

This study looks at how alcohol changes brain activity when people interact with each other. Researchers will use special brain scans (EEG) on pairs of people while they drink and do tasks. The goal is to understand the brain processes behind alcohol's social effects. 240 adults …

This study looks at how being in ketosis (a state from a very low-carb diet) changes the way the body processes alcohol and affects the brain. About 23 healthy adults will follow three different 3-day diets and then drink 4-5 alcoholic beverages. Researchers will use breath tests…

This study looks at how a single dose of a ketone ester supplement (DeltaG) changes glucose use in the brain and heart of people with alcohol use disorder compared to healthy volunteers. Twenty participants will receive either the supplement or a placebo, then undergo PET scans. …

This study aimed to develop a digital health worker named PAHOLA to deliver brief counseling for people who drink too much but avoid traditional treatment. The goal was to see if a computer-based coach could help reduce alcohol use and improve health. The study was withdrawn befo…

This study was designed to test whether a mobile app with personalized feedback and peer coaching could help young adults aged 18-29 who drink heavily and have experienced interpersonal trauma. Participants would have been randomly assigned to the enhanced app or a standard versi…

This study looks at whether taking a ketone supplement before drinking alcohol changes how drunk people feel or how alcohol shows up in their breath or blood. Ten healthy volunteers will drink alcohol on two separate days, once with the supplement and once with a placebo. The goa…