Ketone drink may shed light on Alcohol's toll on brain and heart

NCT ID NCT05015881

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how a single dose of a ketone ester supplement (DeltaG) changes glucose use in the brain and heart of people with alcohol use disorder compared to healthy volunteers. Twenty participants will receive either the supplement or a placebo, then undergo PET scans. The goal is to better understand the link between alcohol misuse and energy metabolism in these organs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketone ester (DeltaG)
What this could lead to: If successful, this could reveal how ketone esters affect brain and heart energy use in alcohol use disorder, pointing toward new ways to understand or manage the condition.
What could go wrong: This is a very small, early-stage study with only 20 participants, so results may not apply broadly. It measures short-term effects after a single dose, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse Alcohol Drinking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL DRINKING ALCOHOL USE DISORDER (AUD)

Contacts and locations

Locations

University of Pennsylvania Center for Studies of Addiction

Philadelphia, Pennsylvania, 19104, United States

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