New daily pill could help manage weight for years

NCT ID NCT07654361

Recruiting now Disease control Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This phase 3 trial tests a once-daily oral drug called aleniglipron for chronic weight management in 3600 adults with obesity or overweight who also have a weight-related health condition. Participants take the drug or a placebo for 76 weeks, along with diet and exercise changes. The study measures weight loss, safety, and effects on blood pressure and cholesterol.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aleniglipron (oral drug)
What this could lead to: If successful, this could provide a new once-daily pill for long-term weight management in people with obesity or overweight.
What could go wrong: This is a phase 3 trial, but results are not yet available. The drug may cause side effects or fail to show meaningful weight loss compared to placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC WEIGHT MANAGEMENT OBESITY OBESITY, OVERWEIGHT, OR CHRONIC WEIGHT MANAGEMENT OVERWEIGHT

Contacts and locations

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Study contacts

Contact

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Locations

ACCOMPLISH-1 Research Site
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Birmingham, Alabama, 35242, United States

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Birmingham, Alabama, 35294-3360, United States

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Phoenix, Arizona, 85225, United States

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Sun City West, Arizona, 85375, United States

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Tucson, Arizona, 85741, United States

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Escondido, California, 92025, United States

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Gardena, California, 92708, United States

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La Jolla, California, 92108, United States

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Modesto, California, 95355, United States

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Rolling Hills Estates, California, 90274, United States

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San Diego, California, 92123, United States

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Clearwater, Florida, 33756, United States

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Leesburg, Florida, 34748, United States

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Miami, Florida, 33136, United States

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Ocala, Florida, 34470, United States

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Ocoee, Florida, 34761, United States

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Pembroke, Florida, 33027, United States

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Tampa, Florida, 33617, United States

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Buford, Georgia, 30046, United States

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Columbus, Georgia, 31904, United States

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Lawrenceville, Georgia, 30046, United States

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Union City, Georgia, 30291, United States

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Woodstock, Georgia, 30189, United States

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Honolulu, Hawaii, 96814-4526, United States

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Meridian, Idaho, 83646, United States

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Rexburg, Idaho, 83440, United States

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Chicago, Illinois, 60637, United States

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Iowa City, Iowa, 52242, United States

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Wichita, Kansas, 67218, United States

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Louisville, Kentucky, 40213, United States

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Baton Rouge, Louisiana, 70808, United States

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Silver Spring, Maryland, 20901-4402, United States

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Methuen, Massachusetts, 01844, United States

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Needham, Massachusetts, 02492, United States

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Ann Arbor, Michigan, 48105-1912, United States

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Mankato, Minnesota, 56001, United States

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Richfield, Minnesota, 55423, United States

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Gulfport, Mississippi, 39503, United States

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Ridgeland, Mississippi, 39157, United States

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Chesterfield, Missouri, 63005, United States

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Hazelwood, Missouri, 63042, United States

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St Louis, Missouri, 63303-3041, United States

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Butte, Montana, 59701, United States

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Missoula, Montana, 59804, United States

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Omaha, Nebraska, 68198-7400, United States

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Las Vegas, Nevada, 89128, United States

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Albany, New York, 12208-3473, United States

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Brooklyn, New York, 11220, United States

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Charlotte, North Carolina, 28210, United States

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Durham, North Carolina, 27710-3000, United States

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Fayetteville, North Carolina, 28304, United States

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New Bern, North Carolina, 28562, United States

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Wilmington, North Carolina, 28401, United States

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Winston-Salem, North Carolina, 27104, United States

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Columbus, Ohio, 43213, United States

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Columbus, Ohio, 43215, United States

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Moore, Oklahoma, 73160, United States

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Portland, Oregon, 97202, United States

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Philadelphia, Pennsylvania, 19152, United States

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Greer, South Carolina, 29651, United States

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Knoxville, Tennessee, 37920, United States

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Austin, Texas, 78704, United States

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Austin, Texas, 78731, United States

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Denison, Texas, 75020-4582, United States

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Houston, Texas, 77040, United States

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Houston, Texas, 77054, United States

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San Antonio, Texas, 78231, United States

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Wylie, Texas, 75098, United States

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Sandy City, Utah, 84094, United States

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St. George, Utah, 84790, United States

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Renton, Washington, 98057, United States

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