New weekly shot aims to treat sleep apnea and obesity together

NCT ID NCT07369011

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This phase 3 trial tests a weekly injection called eloralintide in 800 adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The study looks at whether the drug can improve sleep apnea symptoms and help with weight loss. Participants are divided into two groups: those who cannot or will not use a CPAP machine, and those who already use CPAP.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: eloralintide (a weekly injection)
What this could lead to: If it works, this could offer a new treatment option that reduces both sleep apnea severity and body weight, potentially improving quality of life.
What could go wrong: This is still an experimental drug; it may not prove effective or safe in larger studies. Side effects are possible, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder obstructive sleep apnea syndrome Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT SLEEP APNEA, OBSTRUCTIVE

Contacts and locations

Locations

Advanced Sleep Research
RECRUITING

Berlin, 10117, Germany
All India Institute of Medical Sciences
NOT_YET_RECRUITING

New Delhi, 110029, India
All India Institute of Medical Sciences
NOT_YET_RECRUITING

Raipur, 492099, India
All India Institute of Medical Sciences - Rishikesh
NOT_YET_RECRUITING

Rishikesh, 249203, India
Alpha Recherche Clinique
RECRUITING

Québec, G2J 0C4, Canada
Alpha Recherche Clinique - Lévis
RECRUITING

Lévis, G6V 0C9, Canada
Ark Clinical Research
RECRUITING

Long Beach, California, 90815, United States
Artemis Institute for Clinical Research
RECRUITING

Riverside, California, 92503, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Austin Health - Repatriation Hospital
RECRUITING

Heidelberg West, 3081, Australia
BR Trials - Ensaios Clinicos e Consultoria
SUSPENDED

São Paulo, 01236030, Brazil
Bhakti Vedanta Hospital and Research Institute
NOT_YET_RECRUITING

Thane, 401107, India
Bogan Sleep Consultants
RECRUITING

Columbia, South Carolina, 29201, United States
Box Hill Hospital
RECRUITING

Box Hill, 3128, Australia
C.I.C. Mauricie inc.
RECRUITING

Trois-Rivières, G8T 7A1, Canada
C.I.C. Saint-Laurent
RECRUITING

Saint-Laurent, H4R 3C8, Canada
CDH Research Institute Pty Ltd
RECRUITING

Maroochydore, 4558, Australia
CEMER - Centro Médico do Recife
SUSPENDED

Recife, 51110-160, Brazil
CEPIC - Centro Paulista de Investigação Clínica
SUSPENDED

São Paulo, 04266-010, Brazil
CIMS Studienzentrum Bamberg
RECRUITING

Bamberg, 96049, Germany
CPHosp Medicina, Ensino e Pesquisa (CPQuali)
SUSPENDED

São Paulo, 01228-000, Brazil
CTI Clinical Research Center
RECRUITING

Cincinnati, Ohio, 45212, United States
Care Access - Aurora
RECRUITING

Aurora, Colorado, 80012, United States
Care Access - Shreveport 2
RECRUITING

Shreveport, Louisiana, 71105, United States
Centro de Pesquisa Clínica de Marília - CPCLIM
SUSPENDED

Marília, 17504-072, Brazil
Chang Gung Medical Foundation-Linkou Branch
RECRUITING

Taoyuan, 333, Taiwan
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
China-Japan Friendship Hospital
NOT_YET_RECRUITING

Beijing, 100029, China
Clayton Sleep Institute - St. Louis - Tesson Ferry Road
RECRUITING

St Louis, Missouri, 63123, United States
Collaborative Neuroscience Research, LLC
RECRUITING

Los Alamitos, California, 90720, United States
Consano Clinical Research, LLC
RECRUITING

Shavano Park, Texas, 78231, United States
Core Research Group
RECRUITING

Brisbane, 4064, Australia
Cullman Clinical Trials
RECRUITING

Cullman, Alabama, 35055, United States
Deenanath Mangeshkar Hospital & Research Centre
NOT_YET_RECRUITING

Pune, 411004, India
EBGS Clinical Research Center
RECRUITING

Snellville, Georgia, 30078, United States
Emerald Coast Neurology - Airport Boulevard
RECRUITING

Pensacola, Florida, 32504, United States
Endolife Speciality Hospitals
NOT_YET_RECRUITING

Guntur, 522001, India
Flinders University
RECRUITING

Bedford Park, 5042, Australia
Flourish Research - Bowie
RECRUITING

Bowie, Maryland, 20715, United States
Flourish Research - Miami, LLC
RECRUITING

Miami, Florida, 33135, United States
Fukuoka University Hospital
RECRUITING

Fukuoka, 814-0180, Japan
FutureSearch Trials of Neurology
RECRUITING

Austin, Texas, 78731, United States
Gansu Provincial Hospital
NOT_YET_RECRUITING

Lanzhou, 730000, China
Gold Coast University Hospital
RECRUITING

Southport, 4215, Australia
Headlands Research-Twin Cities
RECRUITING

Maplewood, Minnesota, 55109, United States
Hospital Quiron Infanta Luisa
NOT_YET_RECRUITING

Seville, 41010, Spain
Hospital San Pedro
RECRUITING

Logroño, 26006, Spain
Hospital Universitari de Santa Maria
RECRUITING

Lleida, 25198, Spain
Hospital Universitario La Paz
NOT_YET_RECRUITING

Madrid, 28046, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital Universitario de Guadalajara
RECRUITING

Guadalajara, 19002, Spain
Incor - Instituto do Coracao
SUSPENDED

São Paulo, 05403-900, Brazil
InnoDiab Forschung Gmbh
RECRUITING

Essen, 45136, Germany
Instituto de Investigaciones del Sueño
RECRUITING

Madrid, 28036, Spain
Instituto de Pesquisa clinica de Campinas
SUSPENDED

Campinas, 13060-080, Brazil
Jiangxi Provincial People's Hospital
NOT_YET_RECRUITING

Nanchang, 330038, China
Juntendo University Hospital
RECRUITING

Bunkyō City, 113-8431, Japan
KKR Sapporo Medical Center
RECRUITING

Sapporo, 062-0931, Japan
KRIMS Hospital
NOT_YET_RECRUITING

Nagpur, 440010, India
Kirigaokatsuda Hospital
RECRUITING

Kitakyushu, 802-0052, Japan
Korea University Ansan Hospital
RECRUITING

Ansan-si, 15355, South Korea
Korea University Guro Hospital
NOT_YET_RECRUITING

Seoul, 08308, South Korea
Maple Leaf Research
RECRUITING

Toronto, M5G 1K2, Canada
MyCliniResearch, Inc.
RECRUITING

Calgary, T2Z 3R6, Canada
Nakamura Clinic
RECRUITING

Urasoe, 901-2132, Japan
Nanjing First Hospital
NOT_YET_RECRUITING

Nanjing, 210006, China
National Cheng-Kung Uni. Hosp.
RECRUITING

Tainan, 704, Taiwan
Nightingale Research
RECRUITING

Adelaide, 5000, Australia
Ningbo First Hospital
NOT_YET_RECRUITING

Ningbo, 315010, China
Núcleo de Pesquisa Clínica do Rio Grande do Sul
SUSPENDED

Porto Alegre, 90430-001, Brazil
Osaka Kaisei Hospital
RECRUITING

Osaka, 532-0003, Japan
Palm Research Center Tenaya
RECRUITING

Las Vegas, Nevada, 89128, United States
PharmaDev Clinical Research Institute, LLC
RECRUITING

Miami, Florida, 33176, United States
Prognosis Pesquisa Clínica
SUSPENDED

Santo André, 09040-010, Brazil
RED-Institut GmbH
RECRUITING

Oldenburg, 23758, Germany
RESM Respiratory and Sleep Medical Care Clinic
RECRUITING

Yokohama, 222-0033, Japan
Revive Research Institute, Inc.
RECRUITING

Southfield, Michigan, 48075, United States
Rhythm Heart Institute - A Unit of SLPL
NOT_YET_RECRUITING

Vadodara, 390022, India
Rochester Clinical Research - Buffalo
RECRUITING

Buffalo, New York, 14127, United States
Ruschel Medicina e Pesquisa Clínica
SUSPENDED

Rio de Janeiro, 22270-060, Brazil
SDS Tuberculosis Research Center & Rajiv Gandhi Institute of Chest Diseases
NOT_YET_RECRUITING

Bengaluru, 560029, India
Severance Hospital, Yonsei University Health System
NOT_YET_RECRUITING

Seoul, 03722, South Korea
Shanghai East Hospital
NOT_YET_RECRUITING

Shanghai, 200120, China
Shanghai Sixth People's Hospital
NOT_YET_RECRUITING

Shanghai, 200030, China
ShenZhen People's Hospital
NOT_YET_RECRUITING

Shenzhen, 518020, China
Shenzhen Hospital of Southern Medical University
NOT_YET_RECRUITING

Shenzhen, 518110, China
Sichuan Provincial People's Hospital
NOT_YET_RECRUITING

Chengdu, 610072, China
Sir Ganga Ram Hospital
NOT_YET_RECRUITING

New Delhi, 110060, India
Siteworks - Karlsruhe
RECRUITING

Karlsruhe, 76137, Germany
Siteworks GmbH - Hannover
RECRUITING

Hanover, 30449, Germany
Sleep Therapy Research Center
RECRUITING

San Antonio, Texas, 78229, United States
Social Medical Corporation Sokujinkai Sleep and Mental Health Clinic - Kitahiroshima
RECRUITING

Kitahiroshima, 061-1121, Japan
Somni bene
RECRUITING

Schwerin, 19053, Germany
St. Johns Medical College Hospital
NOT_YET_RECRUITING

Bengaluru, 560034, India
Teak Research Consults
RECRUITING

Lawrenceville, Georgia, 30043, United States
The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITING

Chongqing, 400016, China
The First Affiliated Hospital of Guangzhou Medical University
NOT_YET_RECRUITING

Guangzhou, 510360, China
The First Affiliated Hospital of Henan University of Science &Technology
NOT_YET_RECRUITING

Luoyang Shi, 471003, China
The First Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, 130021, China
The First People's Hospital of Yunnan Province
NOT_YET_RECRUITING

Kunming, 650034, China
The Second Affiliated Hospital of Guangxi Medical University
NOT_YET_RECRUITING

Nanning, 053007, China
The Second Affiliated Hospital of Soochow University
NOT_YET_RECRUITING

Suzhou, 215004, China
The Second Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, 130041, China
The Second People's Hospital of Hefei
NOT_YET_RECRUITING

Hefei, 230011, China
The Sleep Spot - Maimonides
RECRUITING

Albuquerque, New Mexico, 87107, United States
The Third Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, 410013, China
Toranomon Hospital
RECRUITING

Minatoku, 105-8470, Japan
TrialsWest - Spearwood
RECRUITING

Spearwood, 6163, Australia
Universitätsklinikum Marburg
RECRUITING

Marburg, 35033, Germany
Utkal Institute of Medical Sciences and Hospital
NOT_YET_RECRUITING

Bhubaneswar, 751021, India
Wuxi People's Hospital
NOT_YET_RECRUITING

Wuxi, 214023, China
Xianyang Hospital of Yan'an University
NOT_YET_RECRUITING

Xianyang, 712000, China
Yoyogi Sleep Disorder Center
RECRUITING

Shibuya-ku, 151-0053, Japan

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