Can a daily pill tame the obesity epidemic?

NCT ID NCT07743463

Recruiting now Disease control Sponsor: Ascletis Pharma (China) Co., Limited Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This Phase 3 trial is testing an experimental once-daily oral medication called ASC30 in adults with obesity or overweight who also have weight-related health conditions like high blood pressure or sleep apnea. The study aims to see if ASC30 can lead to significant weight loss over 72 weeks compared to a placebo. It will also measure changes in waist size, blood pressure, and other health markers. The trial is double-blind and placebo-controlled, meaning neither participants nor researchers will know who receives the actual drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ASC30, an experimental once-daily oral medication
What this could lead to: If successful, ASC30 could offer a convenient daily pill for chronic weight management, potentially aiding in weight loss and improving related health issues like blood pressure and cholesterol.
What could go wrong: This is a large, late-stage trial, but success is not guaranteed. The drug may not produce significant weight loss or may cause side effects. Long-term safety and effectiveness are still under investigation.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC WEIGHT MANAGEMENT OBESITY OBESITY OR OVERWEIGHT WITH WEIGHT-RELATED COMORBIDITIES OVERWEIGHT

Contacts and locations

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Locations

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Birmingham, Alabama, 35211-1320, United States
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Huntsville, Alabama, 35802, United States
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Phoenix, Arizona, 85020, United States

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Tempe, Arizona, 85284-3499, United States
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Tucson, Arizona, 85741, United States
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Little Rock, Arkansas, 72204, United States
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Banning, California, 92220-3082, United States
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Chula Vista, California, 91910, United States
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Covina, California, 91723-1905, United States
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Gardena, California, 90247-3583, United States
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Tarzana, California, 91356-3508, United States
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Tustin, California, 92780-7074, United States
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Washington D.C., District of Columbia, 20016, United States
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Boca Raton, Florida, 33434, United States
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Daytona Beach, Florida, 32114, United States
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Jacksonville, Florida, 32205-4785, United States
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Leesburg, Florida, 34748-5077, United States
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Melbourne, Florida, 32934-8172, United States

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South Miami, Florida, 33143, United States
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Tampa, Florida, 33613-1244, United States
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The Villages, Florida, 32162, United States

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Winter Park, Florida, 32789-4681, United States
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Canton, Georgia, 30115, United States
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Decatur, Georgia, 30030-3440, United States
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Union City, Georgia, 30291-2085, United States
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Boise, Idaho, 83704, United States
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Schaumburg, Illinois, 60173, United States
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Evansville, Indiana, 47714-7513, United States

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Indianapolis, Indiana, 46254, United States
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Valparaiso, Indiana, 46383, United States
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Kansas City, Kansas, 66112, United States
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Bowie, Maryland, 20715, United States
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Rockville, Maryland, 20854-2931, United States
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Jackson, Mississippi, 39206, United States
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Olive Branch, Mississippi, 38654-3514, United States
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St Louis, Missouri, 63141, United States
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Las Vegas, Nevada, 89113, United States
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New Windsor, New York, 12553-7754, United States
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Charlotte, North Carolina, 28262, United States
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Greenville, North Carolina, 27834-5051, United States
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Morehead City, North Carolina, 28557, United States
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Raleigh, North Carolina, 27610, United States
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Cincinnati, Ohio, 45246, United States
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Cleveland, Ohio, 44122-4330, United States
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Columbus, Ohio, 43212-3122, United States
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Dayton, Ohio, 45414, United States
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Eugene, Oregon, 97404-3233, United States
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Philadelphia, Pennsylvania, 19107, United States
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Pittsburgh, Pennsylvania, 15243-1800, United States
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Bluffton, South Carolina, 29910, United States
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Clemson, South Carolina, 29634, United States
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Columbia, South Carolina, 29204, United States
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Memphis, Tennessee, 38119-4823, United States
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Austin, Texas, 78744-1645, United States

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Brownsville, Texas, 78520, United States
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DeSoto, Texas, 75115-2043, United States
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Frisco, Texas, 75033-4133, United States
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Houston, Texas, 77024, United States
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Mesquite, Texas, 75149, United States
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San Antonio, Texas, 78229-3272, United States

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San Antonio, Texas, 78229-3539, United States
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Sugar Land, Texas, 77478, United States
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Tomball, Texas, 77375, United States
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Weslaco, Texas, 78596-7288, United States
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Wichita Falls, Texas, 76301, United States
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Salt Lake City, Utah, 84124-3543, United States
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Hampton, Virginia, 23666, United States
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Burlington, L7R 1E2, Canada
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Pardubice, 530 02, Czechia
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Prague, 120 00, Czechia
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Prague, 150 00, Czechia
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Uherské Hradiště, 686 01, Czechia
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Berlin, 10629, Germany
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Berlin, 10787, Germany
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Essen, 45355, Germany
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Hanover, 30159, Germany
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Leipzig, 04107, Germany
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Athens, 106 76, Greece
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Athens, 115 27, Greece
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Athens, 115 28, Greece
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Larissa, 411 10, Greece
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Marousi, 151 23, Greece
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Palaió Fáliro, 175 62, Greece
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Pylaia, 570 01, Greece
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Thessaloniki, 546 36, Greece
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Thessaloniki, 546 42, Greece
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Biała Podlaska, 21-500, Poland
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Bydgoszcz, 85-092, Poland
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Częstochowa, 42-202, Poland
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Gdansk, 80-382, Poland
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Gdynia, 81-384, Poland
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Gdynia, 81-537, Poland
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Katowice, 40-040, Poland
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Krakow, 31-261, Poland
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Krakow, 31-501, Poland
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Lodz, 90-127, Poland
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Lodz, 91-363, Poland
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Lublin, 20-011, Poland
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Lublin, 20-362, Poland
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Poznan, 60-324, Poland
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Poznan, 60-702, Poland
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Puławy, 24-100, Poland
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Siedlce, 08-110, Poland
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Staszów, 28-200, Poland
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Torun, 87-100, Poland
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Warsaw, 00-215, Poland
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Warsaw, 00-710, Poland
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Warsaw, 01-696, Poland
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Warsaw, 02-672, Poland
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Warsaw, 03-291, Poland
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Wroclaw, 50-381, Poland
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Wroclaw, 53-673, Poland
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Bellshill, ML4 3NJ, United Kingdom
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Cardiff, CF15 9SS, United Kingdom
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Edgbaston, B16 8QQ, United Kingdom
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London, E1 1AG, United Kingdom
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Manchester, M11 1AA, United Kingdom
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Manchester, M156SE, United Kingdom
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Stoke-on-Trent, ST1 5SJ, United Kingdom
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Warrington, WA1 3TZ, United Kingdom

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