New weekly shot could help sleep apnea and weight loss

NCT ID NCT07571109

Recruiting now Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 8 times

Summary

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who use a breathing device. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Participants are randomly assigned to receive the drug or a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NNC0487-0111 (a weekly injection for weight loss and sleep apnea)
What this could lead to: If it works, this could offer a new weekly injection that helps people with obesity and sleep apnea lose weight and breathe better during sleep.
What could go wrong: This is an early Phase 3 trial with 300 participants, so results may not apply to everyone. The drug may cause side effects or not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder obstructive sleep apnea syndrome Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OBSTRUCTIVE SLEEP APNOEA OVERWEIGHT

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
RECRUITING

Wroclaw, Dolnoslaskie Voivodeship, 50-981, Poland
5 Wojskowy Szpital Kliniczny z Polikliniką-Samodzielny Publiczny Zakład Opieki Zdrowotnej w Krakowie
NOT_YET_RECRUITING

Krakow, 30-901, Poland
Adana Şehir Eğitim ve Araştırma Hastanesi-Dahiliye
RECRUITING

Yuregir/Adana, 01060, Turkey (Türkiye)
Advanced Neurology Epilepsy and Sleep Center ANESC
RECRUITING

El Paso, Texas, 79912, United States
All India Institute of Medical Sciences (AIIMS), Bhubaneswar
NOT_YET_RECRUITING

Bhubaneswar, Odisha, 751019, India
All India Institute of Medical Sciences_Delhi
RECRUITING

Delhi, New Delhi, 110029, India
Amrita Institute Of Medical Sciences & Research Centre
RECRUITING

Kochi, Kerala, 682041, India
Ankara Etlik Şehir Hastanesi-Göğüs Hastalıkları
RECRUITING

Yenimahalle / Ankara, 06170, Turkey (Türkiye)
Apollo Multispeciality Hospital, Kolkata
RECRUITING

Kolkata, West Bengal, 700054, India
Asian Kidney Hospital And Medical Centre
RECRUITING

Nagpur, Maharashtra, 440010, India
Asthma Bhawan
RECRUITING

Jaipur, 302039, India
Bhaktivedanta Hospital & Research Institute
RECRUITING

Mumbai, Maharashtra, 401107, India
Biorhythms Center for Integrative Sleep Medicine
RECRUITING

El Paso, Texas, 79912, United States
Bogan Sleep Consultants, LLC
RECRUITING

Columbia, South Carolina, 29201, United States
Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları
RECRUITING

Yıldırım/Bursa, 16310, Turkey (Türkiye)
CTI Clinical Research Center
RECRUITING

Cincinnati, Ohio, 45212, United States
Cathay General Hospital
RECRUITING

Taipei, 106, Taiwan
Chang Gung Memorial Hospital, Linkou
NOT_YET_RECRUITING

Taoyuan, 333, Taiwan
Chatani NeuroSleep Clinic_Neurology
RECRUITING

Hiroshima, 730-0051, Japan
Chicago Research Center, Inc
RECRUITING

Chicago, Illinois, 60634, United States
Chutoen General Medical Center_Neurology
RECRUITING

Shizuoka, 436-8555, Japan
Clinical Research Associates of Central PA, LLC
NOT_YET_RECRUITING

DuBois, Pennsylvania, 15801, United States
DM Clinical
RECRUITING

Bradenton, Florida, 34209, United States
Dignity Health, Mercy Gilbert
RECRUITING

Gilbert, Arizona, 85297, United States
Ditmanson Medical Foundation Chia-Yi Christian Hospital
NOT_YET_RECRUITING

Chiayi City, 600, Taiwan
ETG Warszawa Sp. z o.o.
RECRUITING

Warsaw, 02-677, Poland
Epic Medical Research
RECRUITING

DeSoto, Texas, 75115, United States
Essence MD Research
RECRUITING

Naples, Florida, 34102, United States
Fukuoka University Hospital_Respiratory Medicine
RECRUITING

Fukuoka, 814-0180, Japan
Government Siddhartha Medical College & Government General Hospital, Vijayawada
RECRUITING

Vijayawada, Andhra Pradesh, 520008, India
Guntur Government medical College
COMPLETED

Guntur, Andhra Pradesh, 522004,, India
Gyncentrum Sp. z o. o.
RECRUITING

Warsaw, 00-124, Poland
H.U. Quirónsalud Madrid
RECRUITING

Pozuelo de Alarcón, Madrid, 28223, Spain
Hitit Üniversitesi Çorum Erol Olçok Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları
RECRUITING

Merkez/Çorum, 19040, Turkey (Türkiye)
Hospital Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Univ. de Santa María de Lleida
RECRUITING

Lleida, 25198, Spain
Hospital Universitario San Pedro
RECRUITING

Logroño, 26006, Spain
Hospital Universitario de Araba
RECRUITING

Vitoria-Gasteiz, 01004, Spain
Hospital Universitario de Guadalajara
RECRUITING

Guadalajara, Castille-La Mancha, 19002, Spain
Hospital Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Vithas Sevilla
RECRUITING

Castilleja de la Cuesta, 41950, Spain
Houston Pulm Med Res Network
RECRUITING

Houston, Texas, 77089, United States
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose
RECRUITING

Münster, 48145, Germany
Instituto de Investigaciones del Sueño
RECRUITING

Madrid, 28036, Spain
Juntendo University Hospital_Cardiovascular Biology And Medicine
RECRUITING

Tokyo, 113-8431, Japan
KKR Sappro Medical Center_Respiratory Medicine
RECRUITING

Sapporo-shi, Hokkaido, 062-0931, Japan
Krakowski Szpital Specjalistyczny im. Jana Pawla II
COMPLETED

Krakow, 31-202, Poland
Kuwamizu Hospital_Internal Medicine
RECRUITING

Kumamoto, 862-0954, Japan
Lillestol Research LLC
RECRUITING

Fargo, North Dakota, 58104, United States
Mater Research - RIO Clinical Trials Unit
NOT_YET_RECRUITING

South Brisbane, Queensland, 4101, Australia
Midland Healthcare & Research Center
RECRUITING

Lucknow, Uttar Pradesh, 226006, India
Nakamura Clinic_Pulmonology
RECRUITING

Okinawa, 901-2132, Japan
Nanfang Hospital, Southern Medical University-Department of Psychiatry and Psychology
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510515, China
National Institute Of Tuberculosis And Lung Diseases - Instytut Gruźlicy i Chorób Płuc
RECRUITING

Warsaw, 01-138, Poland
NeuroTrials Research, Inc.
RECRUITING

Atlanta, Georgia, 30328, United States
Nightingale Research Adelaide
RECRUITING

Adelaide, South Australia, 5000, Australia
Osaka Kaisei Hospital_Sleep Medical Center
RECRUITING

Osaka, 532-0003, Japan
PANSTWOWY INSTYTUT MEDYCZNY MSWiA
RECRUITING

Warsaw, 02-507, Poland
Palm Beach Research Center
RECRUITING

West Palm Beach, Florida, 33409, United States
Peking University People's Hospital-Endocrinology
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100044, China
Penta Hospitals Badania Kliniczne Sp. z o.o.
RECRUITING

Gdansk, 80-546, Poland
Physicians Research Associates
RECRUITING

Lawrenceville, Georgia, 30046, United States
Rainier Clin Res Ctr Inc
RECRUITING

Renton, Washington, 98057, United States
Rajarajeswari Medical College and Hospital
RECRUITING

Bengaluru, Karnataka, 560074, India
Seattle Clinical Research Center
RECRUITING

Seattle, Washington, 98104, United States
Shenzhen People's Hospital-Sleep Medicine Department
NOT_YET_RECRUITING

Shenzhen, Guangdong, 518020, China
Siteworks GmbH - Prüfzentrum Schleswig | RespiRatio
RECRUITING

Schleswig, 24837, Germany
Siteworks GmbH Bochum
RECRUITING

Bochum, 44787, Germany
Siteworks GmbH Hannover
RECRUITING

Hanover, 30449, Germany
Siteworks GmbH Karlsruhe
RECRUITING

Karlsruhe, 76137, Germany
Sleep Therapy Research Center
RECRUITING

San Antonio, Texas, 78229, United States
T.C. Sağlık Bakanlığı Alaaddin Keykubat Üniversitesi Alanya Eğitim ve Araştırma Hastanesi-Göğüs Hastalıkları
RECRUITING

Alanya/ Antalya, 07400, Turkey (Türkiye)
Taipei Medical University Hospital
RECRUITING

Taipei, 110, Taiwan
Taipei Municipal Wan Fang Hospital_Division of Otorhinolaryngology
RECRUITING

Taipei, 116, Taiwan
The First Affiliated Hospital of Henan University of Science and Technology-Endocrinology
NOT_YET_RECRUITING

Luoyang, Henan, 471003, China
The Second Affiliated Hospital of Nanjing Medical University-Endocrinology
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210011, China
Tianjin Medical University General Hospital-Respiratory
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300052, China
Tokyo Tenshi Hospital_Internal medicine
RECRUITING

Tokyo, 193-0811, Japan
Tokyo-Eki Center-building Clinic_Internal Medicine
RECRUITING

Tokyo, 103-0027, Japan
Tricoastal Sleep Center
RECRUITING

Sugar Land, Texas, 77478, United States
University of Sunshine Coast - Vitality Village
RECRUITING

Birtinya, Queensland, 4575, Australia
University of Western Australia - Centre for Sleep Science
RECRUITING

Crawley, Western Australia, 6009, Australia
Uniwersytecki Szpital Kliniczny W Poznaniu
RECRUITING

Poznan, 60-569, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-214, Poland
Vardhaman Mahavir Medical College & Safdarjung Hospital
NOT_YET_RECRUITING

New Delhi, National Capital Territory of Delhi, 110029, India
Weil Cornell Medicine
RECRUITING

New York, New York, 10021, United States
Wendisch - Dahl Hamburg - DZHW
RECRUITING

Hamburg, 22607, Germany
Woolcock Institute
RECRUITING

Macquarie Park, New South Wales, 2113, Australia
Yashoda Hospital
COMPLETED

Hyderabad, Telangana, 500084, India
Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi
RECRUITING

Zeytinburnu/İstanbul, 34020, Turkey (Türkiye)
İnönü Üniversitesi Turgut Özal Tıp Merkezi Hastanesi- Göğüs Hastalıkları
RECRUITING

Merkez/Battalgazi/Malatya, 44280, Turkey (Türkiye)
İstanbul İl Sağlik Müdürlüğü Süreyyapaşa Göğüs Hastaliklari Ve Göğüs Cerrahisi Eğitim Ve Araştirma Hastanesi
RECRUITING

Maltepe/İstanbull, 34843, Turkey (Türkiye)

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