Ultrasound zaps depression? tiny trial tests new brain treatment

NCT ID NCT06013384

Terminated Symptom relief Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small pilot study tested whether low-intensity focused ultrasound can safely ease symptoms in people with treatment-resistant depression. The device targets a brain region linked to mood. Only 1 person was enrolled, and the trial is currently suspended, so results are very limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Low-intensity focused ultrasound pulsation (device)
What this could lead to: If it works, this could point toward a new, non-invasive way to treat severe depression that hasn't responded to other therapies.
What could go wrong: This is a very early, tiny pilot study with only 1 participant and the trial is currently suspended. Results may not apply to others, and the approach may not prove effective or safe in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

30 Bee Street

Charleston, South Carolina, 29403, United States

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