TREATMENT RESISTANT DEPRESSION

This study is testing whether a single dose of psilocybin (the active compound in 'magic mushrooms'), given alongside supportive psychotherapy, is safe and can help reduce symptoms of depression and substance use. It will involve 50 veterans and first responders who have not resp…

This study tests whether an intensive, personalized form of magnetic brain stimulation can help older adults with depression that hasn't responded to medication and who also have memory problems. Researchers will compare the real stimulation to a placebo (sham) treatment in 186 p…

This study is testing if adding an investigational drug called NRX-101 to a non-invasive brain stimulation treatment (TMS) works better than TMS alone. It is for adults with severe depression that hasn't improved with at least two standard antidepressant medications. The goal is …

This study aims to understand if having a trained guide, or 'monitor,' present during psilocybin therapy sessions improves the treatment for adults with severe depression that hasn't responded to other medications. It will involve 40 participants to test the safety and feasibilit…

This study is testing whether nitrous oxide, commonly known as laughing gas, can help people whose depression hasn't improved with standard antidepressants. 120 adults with treatment-resistant depression will receive either laughing gas or a control treatment once a week for four…

This small pilot study aims to see if combining a fast-acting depression medication (ketamine) with immersive virtual reality (VR) is a better treatment than ketamine alone for adults with depression that hasn't responded to other medications. All 31 participants will receive sta…

This study aims to find out why some people with depression get better with treatment while others do not. Researchers will collect detailed information from 2,000 participants, including genetic data, blood tests, and surveys about symptoms and life experiences. The goal is to u…

This study aims to understand how an implanted vagus nerve stimulator affects the brain and body in people with hard-to-treat depression. It will enroll 12 adults who already have the device implanted as part of another clinical trial. Researchers will use brain scans (EEG and fM…

This study aims to find out if special light-sensitive cells in the back of the eye can help predict which patients with hard-to-treat depression will respond well to a non-invasive brain stimulation therapy. Researchers will give 44 participants with treatment-resistant depressi…