TREATMENT RESISTANT DEPRESSION

This study tests whether adding a drug called NRX-101 (a mix of D-cycloserine and lurasidone) to transcranial magnetic stimulation (TMS) helps people with treatment-resistant depression more than TMS alone. About 400 adults who have not had TMS before will receive either the drug…

This study tests a new, intensive form of brain stimulation for elderly people (65 and older) who have depression that hasn't improved with medication and also have memory or thinking problems. The treatment uses magnetic pulses targeted to a specific brain area, guided by brain …

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with psychotherapy is safe and can reduce depression and substance use in veterans and first responders who haven't responded to standard treatments. Fifty participants will r…

This Phase 3 trial tests whether inhaling nitrous oxide (laughing gas) can reduce depression symptoms in 120 adults with treatment-resistant major depressive disorder. Participants will receive either nitrous oxide plus a placebo or oxygen plus a mild sedative, and their mood wil…

This study tests whether a brain stimulation treatment for depression called iTBS can be improved by customizing it to each person's brain signals. Researchers will use EEG to measure brain responses and find the best stimulation settings for 80 adults with treatment-resistant de…

This Stanford study will look at how an implanted vagus nerve stimulation device changes brain activity in 12 adults with treatment-resistant depression. Researchers will measure brain waves and heart signals to understand the device's effects. It is an early, exploratory study f…

This study will follow 2,000 adults with major depressive disorder or bipolar disorder to understand why some people get better with treatment and others do not. Researchers will collect information on symptoms, thinking abilities, genetics, metabolism, proteins, and immune marke…