TREATMENT RESISTANT DEPRESSION

This small, early-stage study tested a new drug called ALA-3000 in people whose depression had not improved with at least two standard treatments. The main goal was to check the drug's safety, side effects, and how it moves through the body in 37 participants. Researchers also lo…

This study tested whether adding the antibiotic minocycline to standard antidepressant medication helps people with treatment-resistant depression. In this 12-week trial, 76 adults who hadn't responded well to their current antidepressants were randomly assigned to receive either…

This Stanford University study tested whether a faster version of magnetic brain stimulation could help people with depression that hasn't responded to other treatments. 48 participants with treatment-resistant depression received either real brain stimulation or a sham (fake) tr…

This study tested whether a single, supervised dose of psilocybin (the active compound in 'magic mushrooms') is safe and can help people with severe depression that hasn't responded to other treatments, and who also have ongoing suicidal thoughts. It involved 20 adults who had no…

This study tested new software designed to help doctors more precisely target a brain stimulation treatment called TMS for people with treatment-resistant depression. Researchers worked with 22 participants to see if using brain scans to create a personalized 'virtual map' for co…

This study tested a faster form of brain stimulation for people with severe, treatment-resistant depression, especially those who struggle to feel pleasure. Researchers wanted to see if a new, quicker stimulation method could reduce depression symptoms. The study involved 79 adul…

This study tested a new way to use gentle electrical brain stimulation for people with major depression that hasn't improved with standard treatments. It compared a stronger, more frequent stimulation schedule against a standard schedule and a fake (placebo) treatment. The main g…

This small pilot study tested whether giving intravenous ketamine alongside a specialized form of talk therapy (RO DBT) is safe and feasible for adults with moderate to severe depression that hasn't improved with standard treatments. The research aimed to see if this combined app…

This study tested whether a special type of brain training using real-time MRI scans could help people with depression that hasn't improved with standard antidepressant medications. Participants learned to increase activity in a brain area linked to positive emotions while recall…

This study tested whether a low-dose ketamine infusion could quickly reduce depression symptoms in teenagers whose depression hasn't improved with standard antidepressants. Researchers compared the ketamine infusion to a placebo (saltwater) infusion in a small group of adolescent…

This small, completed study from Stanford University tested a much faster version of a non-invasive brain stimulation treatment for people with severe bipolar depression that hasn't improved with standard therapies. All seven participants received the accelerated treatment, which…

This study tested new software that uses MRI brain scans to help doctors more accurately target brain stimulation therapy for treatment-resistant depression. Researchers scanned 20 healthy volunteers' brains and recorded positions for the stimulation device. The data helps develo…

This study aimed to understand how nitrous oxide (laughing gas) might help people with depression that hasn't responded to other treatments. Researchers used ultrasound and MRI brain scans on 30 women (20 with depression and 10 healthy volunteers) before, during, and after a one-…