Brain zaps for depression? DBS device tested in 46 patients

NCT ID NCT03653858

Completed Disease control Sponsor: University Hospital Freiburg Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether deep brain stimulation (DBS) can help people with severe depression that hasn't responded to other treatments. 46 patients received either active DBS or a sham (inactive) device. The goal was to see if DBS reduces depression symptoms safely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: deep brain stimulation (DBS) device
What this could lead to: If it works, this could offer a new option for people with severe depression that hasn't improved with other treatments.
What could go wrong: This is a small, early-stage trial with only 46 participants. The effects may not be large or lasting, and brain surgery carries risks like infection or bleeding.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION

Contacts and locations

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Locations

University Hospital Freiburg

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Université Grenoble Alpes

Grenoble, 38043, France

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