Magic mushroom compound targets Depression's blahs in small trial

This small pilot study tested whether a single 25mg dose of psilocybin, given with psychological support, could help people with treatment-resistant depression who still struggle with anhedonia—the inability to feel pleasure or interest. Twenty adults took either the full dose or a very low 'active placebo' dose. Researchers measured changes in self-reported anhedonia scores over time. The study is already completed, and results may show whether this approach is worth testing in larger trials.