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Brain zap study seeks to map depression relief

NCT ID NCT04243798

Completed Knowledge-focused Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an accelerated form of brain stimulation (theta-burst TMS) in 48 adults with treatment-resistant depression. Half received real stimulation, half received sham. The main goal was to measure changes in brain connectivity using MRI, not to directly treat depression. It was a small, early-stage trial focused on understanding how the brain responds to stimulation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Transcranial magnetic stimulation (TMS) device
What this could lead to
If successful, this could help identify how brain stimulation works for depression, potentially leading to more effective treatments.
What could go wrong
This is a small, early-stage study focused on brain imaging, not on proving the treatment works. The results may not lead to a new therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

  • Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine

    Stanford, California, 94305, United States

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