Magic mushroom compound takes on tough depression in major trial

NCT ID NCT05624268

Completed Symptom relief Sponsor: COMPASS Pathways Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether a single dose of COMP360 psilocybin, given under supportive conditions, can safely reduce depression symptoms in 255 adults with treatment-resistant depression. Participants are randomly assigned to receive either the drug or a placebo, and their mood and daily functioning are tracked over time. The study aims to see if this psychedelic-assisted approach offers relief where standard treatments have failed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: psilocybin (COMP360)
What this could lead to: If it works, this could offer a new, fast-acting option for people with depression that hasn't responded to other treatments.
What could go wrong: This is a single-dose study, and long-term effects are unknown. The psychedelic experience may cause temporary distress, and not everyone may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

APG Research, LLC

Orlando, Florida, 32803, United States
ASCLEPES Research Centers

Thousand Oaks, California, 93012, United States
ATP Clinical Research, Inc.

Orange, California, 92868, United States
Alivation Research, LLC.

Lincoln, Nebraska, 68526, United States
Artemis Institute for Clinical Research

San Diego, California, 92103, United States
Bio Behavioral Health

Toms River, New Jersey, 08755, United States
CBH Health, LLC

Gaithersburg, Maryland, 20877, United States
CalNeuro Research Group, Inc

Los Angeles, California, 90025, United States
California Center for Psychedelic Therapy

Los Angeles, California, 90004, United States
Cedar Clinical Research

Draper, Utah, 84020, United States
Clarity Clinical Research, LLC

Los Angeles, California, 90064, United States
Clinical Neurosciecne Solutions, Inc. dba CNS Healthcare

Orlando, Florida, 32801, United States
Collaborative Neuroscience Network, LLC

Garden Grove, California, 92845, United States
Comprehensive Psychiatric Care

Norwich, Connecticut, 06360, United States
Core Clinical Research

Everett, Washington, 98201, United States
DMI Health Care Group, Inc

Tampa, Florida, 33782, United States
Emory University

Atlanta, Georgia, 30329-2209, United States
Global Medical Institutes, LLC, Scranton Medical Institute

Moosic, Pennsylvania, 18507, United States
Insight Clinical Trials, LLC

Beachwood, Ohio, 44122, United States
Kadima Neuropsychiatry Institute

La Jolla, California, 92037, United States
Lumos Clinical Research Center

San Jose, California, 95124, United States
Meridien Research/Accel Research

Tampa, Florida, 33803, United States
Midwest Research Group

Saint Charles, Missouri, 63304, United States
Neuro-Behaviroral Clinical Research, Inc.

North Canton, Ohio, 44720, United States
New York State Psychiatric Institute

New York, New York, 10032, United States
Pharmasite Research, Inc

Pikesville, Maryland, 21208, United States
ProScience Research Group

Culver City, California, 90230, United States
Psych Atlanta

Atlanta, Georgia, 30060, United States
Rivus Wellness & Research Institute

Oklahoma City, Oklahoma, 73112, United States
Sheppard Pratt Health System

Baltimore, Maryland, 21044, United States
Stanford University

Stanford, California, 94305, United States
The Medical Research Network, LLC

New York, New York, 10128, United States
UT Health Science Center at Houston (UTHSC-H)

Houston, Texas, 77030, United States
University California San Diego

La Jolla, California, 92037, United States
University of Arizona College of Medicine - Tuscon

Tuscon, Arizona, 85724, United States
University of Massachusetts Medical School

North Worcester, Massachusetts, 01655, United States
University of Minnesota

Minneapolis, Minnesota, 55416, United States
University of Missouri

Columbia, Missouri, 65212, United States
Uptown Research Institute, LLC

Chicago, Illinois, 60640, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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