Brain-Zap tech gets a GPS: virtual navigation aims to boost TMS for tough depression

NCT ID NCT04956081

Completed Symptom relief Sponsor: Soterix Medical Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a virtual navigation system to help guide Transcranial Magnetic Stimulation (TMS) for people with treatment-resistant depression. The system aims to personalize the brain target for each patient. Twenty-two adults with major depressive disorder who had not responded to at least two prior treatments took part. The goal was to see if this approach could reduce depression symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial Magnetic Stimulation (TMS) device
What this could lead to: If this works, it could make TMS more effective for people with hard-to-treat depression by better targeting the right brain area.
What could go wrong: This was a small, early-phase study with only 22 people, so results may not apply to everyone. The technology is still experimental and may not improve outcomes significantly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

Soterix Medical, Inc.

Woodbridge, New Jersey, 07095, United States

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Other studies related to the condition(s) this trial covers.