Brain pacemaker tested for untreatable depression
NCT ID NCT02046330
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Sixteen adults aged 22 to 70 will have electrodes implanted in a brain region called the medial forebrain bundle. The device delivers mild electrical pulses to try to improve mood and reduce symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Deep brain stimulation device (Medtronic Percept PC system with Model 3387/3389 leads)
- What this could lead to
- If it works, this could offer a new option for people with severe depression that hasn't responded to other treatments.
- What could go wrong
- This is a very small, early pilot study with only 16 people. It may not show clear benefit, and brain surgery carries risks like infection or bleeding.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
UT Center of Excellence on Mood Disorders
Houston, Texas, 77054, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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