Brain Radio' trial hopes to crack code of depression treatment
NCT ID NCT04106466
First seen Feb 17, 2026
Summary
This study tests a special deep brain stimulation (DBS) device that can both stimulate and record brain activity in people with treatment-resistant depression. Ten participants will have electrodes implanted in a brain region called the subcallosal cingulate. The goal is to identify brain signals that correlate with mood improvement, which could help doctors fine-tune DBS therapy in the future. Participants will track their mood and brain data daily for the first year, with a brief period where the device is turned off to study changes.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Icahn School of Medicine at Mount Sinai, Mount Sinai West
New York, New York, 10019, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Deep brain stimulation (DBS) device
What this could lead to
If successful, this could lead to better ways to personalize DBS settings for depression, improving response rates and reducing trial-and-error adjustments.
What could go wrong
This is a very small, early-stage study (10 people) focused on understanding brain signals, not proving a treatment works. The device requires brain surgery, which carries risks like infection or bleeding.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.