Sound waves to the brain: a new hope for Treatment-Resistant depression?

NCT ID NCT06085950

Recruiting now Symptom relief Sponsor: Centre Hospitalier St Anne Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study explores whether low-intensity ultrasound waves aimed at specific brain areas can ease symptoms in people with treatment-resistant depression. Thirty-two adults aged 18 to 75 who have not responded to at least two antidepressant treatments will receive personalized ultrasound stimulation. Researchers will measure changes in depression severity using a standard scale and monitor for any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial ultrasonic stimulation prototype
What this could lead to: If effective, this could offer a non-invasive, drug-free option for people with depression that hasn't responded to standard treatments.
What could go wrong: This is a small, early pilot study without a placebo group, so results may not prove effectiveness. The approach is experimental and may not work for everyone.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

GHU Sainte-Anne
RECRUITING

Paris, 75014, France

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Other studies related to the condition(s) this trial covers.