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Magic mushroom microdoses could lift depression when nothing else works

NCT ID NCT07183748

Recruiting now Symptom relief Sponsor: Beersheva Mental Health Center Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 10, 2026 · Updated 27 times

Summary

This study tests whether very small, repeated doses of psilocybin (the active ingredient in magic mushrooms) combined with short-term talk therapy can safely reduce depression in people who haven't gotten better with standard treatments. Twenty adults aged 18-65 with treatment-resistant depression will receive either psilocybin or a placebo for six weeks, then switch groups. Researchers will track mood, thinking skills, and biological markers like stress hormones to see if this approach works.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mental Health Center Beer Sheva

    RECRUITING

    Beersheba, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

TREATMENT-RESISTANT DEPRESSION