Magic mushroom microdoses could lift Treatment-Resistant depression
NCT ID NCT07183748
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether very small, repeated doses of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce depression symptoms in people who haven't gotten better with standard treatments. Twenty adults aged 18-65 with treatment-resistant depression will receive either psilocybin or a placebo for six weeks, along with psychotherapy. Researchers will track mood, thinking skills, and biological markers like stress hormones.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin
What this could lead to
If it works, this could point toward a new option for people with depression that hasn't responded to other treatments.
What could go wrong
This is a very small early-phase study with only 20 people. It may not show clear benefits, and participants must stop their usual medications, which carries risks.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for TREATMENT RESISTANT DEPRESSION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Mental Health Center Beer Sheva
RECRUITINGBeersheba, Israel
Contact Phone: •••-•••-•••• Email: •••••@•••••