New hope for depression: quick switch to stronger meds may prevent chronic suffering

NCT ID NCT05973851

Recruiting now Symptom relief Sponsor: Dr. Inge Winter Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a 6-week intensified drug treatment can help people with major depression who did not get better on their first antidepressant. About 418 adults aged 18–65 will receive either the stronger treatment or usual care. The goal is to reduce depression symptoms faster and prevent the condition from becoming long-term.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

Azienda Ospedaliero-Universitaria "Città della Salute e della Scienza di Torino"
NOT_YET_RECRUITING

Turin, Italy
Eginition Hospital, department of psychiatry
NOT_YET_RECRUITING

Athens, 11528, Greece
Fundació Clínic per a la Recerca Biomèdica
RECRUITING

Barcelona, Spain
King's College London, Psychiatry & Cognitive Neuroscience
NOT_YET_RECRUITING

London, SE5 8AF, United Kingdom
LWL-Klinik Dortmund, Bereich Forschung & Wissenschaft
RECRUITING

Dortmund, 44287, Germany
Medical University Innsbruck
RECRUITING

Innsbruck, Austria
Universita degli Studi di Brescia
NOT_YET_RECRUITING

Brescia, Italy
University Hospital Frankfurt am Main - Goethe University
RECRUITING

Frankfurt am Main, Germany
University of Cagliari
RECRUITING

Cagliari, Italy
Università degli studi della Campania Luigi Vanvitelli
RECRUITING

Naples, 80138, Italy
Universitätsklinik für Psychiatrie und Psychotherapie Bielefeld
RECRUITING

Bielefeld, Germany
Westfälische Wilhelms-Universität Münster
RECRUITING

Münster, Germany

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