New hope for Hard-to-Treat depression? schema therapy put to the test

NCT ID NCT05833087

Recruiting now Symptom relief Sponsor: Region of Southern Denmark Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a type of talk therapy called schema therapy for people whose depression has lasted a long time or hasn't gotten better with medication. 129 participants will either get 30 sessions of schema therapy or standard psychotherapy. The goal is to see if schema therapy works better for easing depression symptoms and related problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: schema therapy (a type of psychotherapy)
What this could lead to: If it works, this could give people with long-lasting, hard-to-treat depression a new, more effective therapy option.
What could go wrong: This is a relatively small trial (129 people) and results may not apply to everyone. The therapy is time-intensive (30 sessions), and it may not work better than existing treatments.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant dysthymic disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC DEPRESSION TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

Local Psychiatry Odense, Region of Southern Denmark Psychiatry
RECRUITING

Odense, Denmark
Outpatient clinic for Affective Disorders, Frederiksberg, Capital Region of Denmark Psychiatry
NOT_YET_RECRUITING

Copenhagen, 2000, Denmark
Psychiatric Unit Odense-Svendborg, Southern Region of Denmark Psychiatry
NOT_YET_RECRUITING

Svendborg, 5700, Denmark
Psychotherapeutic Clinic Frederiksberg, Psychiatric Center Copenhagen, Mental Health Services, Capital Region of Denmark
RECRUITING

Frederiksberg, Denmark
Psychotherapeutic Out-patient Clinic, Psychiatric Center Ballerup, Mental Health Services, Capital Region of Denmark
RECRUITING

Ballerup Municipality, 2750, Denmark
Psychotherapeutic Out-patient Clinic, Psychiatric Center Copenhagen/Nannasgade, Mental Health Services, Capital Region of Denmark
RECRUITING

Copenhagen, 2200, Denmark

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