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Sound waves may unlock secrets of Treatment-Resistant depression

NCT ID NCT07166289

Recruiting now Knowledge-focused Sponsor: Laureate Institute for Brain Research, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether low-intensity focused ultrasound can temporarily change brain activity in people with treatment-resistant depression. Researchers will scan participants' brains before and after ultrasound to see how it affects mood-related circuits. The goal is not to treat depression directly, but to better understand which brain connections are involved, so future treatments can be more targeted.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
low-intensity focused ultrasound
What this could lead to
If successful, this could pinpoint precise brain targets for new treatments that help people with treatment-resistant depression who have not responded to standard therapies.
What could go wrong
This is an early-stage mechanistic study, not a treatment trial. It may not lead directly to a therapy, and the effects of ultrasound on depression symptoms are still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Laureate Institute for Brain Research

    RECRUITING

    Tulsa, Oklahoma, 74136, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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