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Could online therapy plus ketamine rapidly curb suicidal thoughts?

NCT ID NCT06480500

Recruiting now Disease control Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether combining internet-based cognitive behavioural therapy (i-CBT) with intravenous ketamine can quickly reduce suicidal thoughts and behaviors in people with treatment-resistant depression. All 110 participants will receive weekly i-CBT for 13 weeks, and half will also get six infusions of ketamine (the other half get a control drug, midazolam). The goal is to see if the combo works faster and better than i-CBT alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ketamine hydrochloride
What this could lead to
If successful, this combination could provide a fast-acting, scalable treatment to reduce suicidal thoughts and behaviors in people with hard-to-treat depression.
What could go wrong
This is a phase 2 trial with only 110 participants, so results may not apply to everyone. Ketamine can cause side effects like dissociation and nausea, and the added benefit over i-CBT alone is not yet proven.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder Suicide

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER SUICIDE TREATMENT RESISTANT DEPRESSION

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Toronto General Hospital

    RECRUITING

    Toronto, Ontario, Canada

    Contact

    Contact Email: •••••@•••••

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