5-Day brain zapping trial aims to lift severe depression

NCT ID NCT06895863

Recruiting now Symptom relief Sponsor: Danish Research Centre for Magnetic Resonance Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests a new, accelerated form of brain stimulation for people with severe depression that hasn't improved with medication. Over five days, 78 participants will receive 25 sessions of magnetic stimulation, either targeting a standard brain area or a new one, or a sham (fake) treatment. The goal is to see if this fast, personalized approach can safely and quickly ease depression symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: transcranial magnetic stimulation (TMS) using intermittent theta burst stimulation (iTBS)
What this could lead to: If it works, this could offer a fast, non-invasive treatment option for people with severe depression that hasn't responded to medication.
What could go wrong: This is a relatively small, early-stage trial testing two different brain targets. It's not yet proven to work, and the effects may be modest or not last long.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

Centre of Neuropsychiatric Depression Research
RECRUITING

Glostrup Municipality, 2600, Denmark
Danish Research Centre for Magnetic Resonance
NOT_YET_RECRUITING

Hvidovre, 2650, Denmark
Mental Health Center North Zealand
NOT_YET_RECRUITING

Hilleroed, 3400, Denmark

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