Could a psychedelic and brain zapping beat depression?

NCT ID NCT06132178

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for adults aged 22-65 with major depression that hasn't improved with other treatments. Researchers want to see if giving psilocybin (the active ingredient in magic mushrooms) followed by a quick, focused brain stimulation technique is safe and can help reduce depression symptoms. The study involves 100 participants and uses brain scans and questionnaires to track changes.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder Depressive Disorder, Treatment-Resistant endogenous depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600

    RECRUITING

    Austin, Texas, 78712, United States

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