Could a neck implant lift severe depression?

NCT ID NCT03887715

Recruiting now Disease control Sponsor: LivaNova Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a device that stimulates the vagus nerve in the neck to treat depression that hasn't responded to other treatments. About 6,800 people will either get the active implant or a sham device. Researchers will track depression symptoms over 12 months to see if the stimulation helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vagus nerve stimulation (VNS) device
What this could lead to: If it works, this could offer a new long-term option for people with depression that hasn't improved with standard treatments.
What could go wrong: This is a large but ongoing trial, and results are not yet known. The device requires surgery and carries risks like infection or nerve side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Depression Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION

Contacts and locations

Show contact details

Locations

AMR- Baber Research, Inc.
RECRUITING

Naperville, Illinois, 60563, United States
APG Research, LLC
RECRUITING

Orlando, Florida, 32803, United States
ATP Clinical Research, Inc.
RECRUITING

Costa Mesa, California, 92626, United States
Access Multi Specialty Medical Clinic, Inc
TERMINATED

Burlingame, California, 94010, United States
Advanced Research Institute, Inc.
TERMINATED

Indianapolis, Indiana, 56268, United States
Alivation Research, LLC
RECRUITING

Lincoln, Nebraska, 68526, United States
Andrew Bishop, MD
TERMINATED

Jackson, Mississippi, 39216, United States
Beacon Medical Group Behavioral Health
ACTIVE_NOT_RECRUITING

South Bend, Indiana, 46601, United States
BioBehavioral Research of Austin
TERMINATED

Austin, Texas, 78759, United States
CMB Clinical Trials
WITHDRAWN

Colton, California, 92324, United States
Carilion Clinic
RECRUITING

Roanoke, Virginia, 24014, United States
Center For Anxiety and Depression
RECRUITING

Mercer Island, Washington, 98040, United States
Central Miami Medical Institute, LLC
WITHDRAWN

Miami, Florida, 33125, United States
Charak Center for Health and Wellness
RECRUITING

Garfield Heights, Ohio, 44125, United States
Clinical Insights
WITHDRAWN

Glen Burnie, Maryland, 21061, United States
Clintex Research Group, Inc.
TERMINATED

Miami, Florida, 33135, United States
Dent Neurological Institute
RECRUITING

Amherst, New York, 14226, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Erie County Medical Center/State University of New York (SUNY) at Buffalo Affiliate
WITHDRAWN

Buffalo, New York, 14215, United States
Florida Behavioral Psych
RECRUITING

Largo, Florida, 33770, United States
Florida Center for TMS
TERMINATED

Orlando, Florida, 32806, United States
Florida Center for TMS
TERMINATED

Saint Augustine, Florida, 32086, United States
Flourish Research - St. Augustine
RECRUITING

Jacksonville, Florida, 32216, United States
Galiz Research LLC
RECRUITING

Hialeah, Florida, 33016, United States
Hapworth Research Inc.
TERMINATED

New York, New York, 10019, United States
Healthy Perspective
RECRUITING

Nashua, New Hampshire, 03060, United States
Houston Clinical Trials
TERMINATED

Houston, Texas, 77401, United States
IACT Health
WITHDRAWN

Grayson, Georgia, 30017, United States
IPTB Clinical Research
RECRUITING

Tampa, Florida, 33612, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Jersey Shore University Medical Center
WITHDRAWN

Neptune City, New Jersey, 07753, United States
Joliet Center For Clinical Research
TERMINATED

Joliet, Illinois, 60435, United States
K2 Medical Research
RECRUITING

Tampa, Florida, 33634, United States
Kaizen Brain Center
RECRUITING

La Jolla, California, 92037, United States
Keck Hospital of USC
RECRUITING

Los Angeles, California, 90033, United States
ManuMind Interventional Psychiatry
RECRUITING

Woodbury, New York, 11797, United States
Marshall University Joan C. Edwards School of Medicine
RECRUITING

Huntington, West Virginia, 25701, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Medical College of Georgia, Augusta University
RECRUITING

Augusta, Georgia, 30912, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Medycal Research, Inc
TERMINATED

Brooksville, Florida, 34609, United States
Michigan Clinical Research Institute PC
RECRUITING

Ann Arbor, Michigan, 48105, United States
Millenia Psychiatry & Research, Inc
WITHDRAWN

Orlando, Florida, 32819, United States
Mindful Behavioral Health
RECRUITING

Boca Raton, Florida, 33431, United States
Mindpath Care Centers
TERMINATED

Raleigh, North Carolina, 27606, United States
NPC Research
WITHDRAWN

Oklahoma City, Oklahoma, 73109-3834, United States
Neuropsychiatric Associates, Plc
TERMINATED

Woodstock, Vermont, 05091, United States
Neuroscience Research Institute
WITHDRAWN

Winfield, Illinois, 60910, United States
Neuroscience and TMS Treatment Center
RECRUITING

Brentwood, Tennessee, 37027, United States
Northpointe Psychiatry
RECRUITING

Lewisville, Texas, 75057, United States
Nova Psychiatry Inc.
RECRUITING

Orlando, Florida, 32803, United States
Ocean Blue Medical Research Center
WITHDRAWN

Miami Springs, Florida, 33166, United States
PACT Atlanta LLC
TERMINATED

Decatur, Georgia, 30030, United States
Pearl Health Clinic
WITHDRAWN

Ammon, Idaho, 83406, United States
Precise Research Centers
RECRUITING

Flowood, Mississippi, 39232, United States
Psych Atlanta
RECRUITING

Marietta, Georgia, 30060, United States
PsychCare Consultants Research
TERMINATED

St Louis, Missouri, 63128, United States
Psychiatric Care and Research
RECRUITING

O'Fallon, Missouri, 633668, United States
Psychiatric Medicine Associates, LLC
RECRUITING

Skokie, Illinois, 60076, United States
Psychiatric Specialty Center
TERMINATED

West Palm Beach, Florida, 33409, United States
Quantum Laboratories Inc.
TERMINATED

Pompano Beach, Florida, 33064, United States
Research Center Of Florida, Inc
WITHDRAWN

Miami, Florida, 33135, United States
Richmond Behavioral Associates
WITHDRAWN

Staten Island, New York, 10312, United States
Rise Clinical Research, LLC
TERMINATED

Missouri City, Texas, 77459, United States
Rivus Wellness & Research Institute
TERMINATED

Oklahoma City, Oklahoma, 73112, United States
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States
SF-CARE, Inc.
TERMINATED

San Rafael, California, 94901, United States
Scranton Medical Institutes
RECRUITING

Moosic, Pennsylvania, 18507, United States
Seattle Neuropsychiatric Treatment Center
RECRUITING

Seattle, Washington, 98104, United States
Segal Trials Corporate
WITHDRAWN

Lauderhill, Florida, 33319, United States
Sheppard Pratt Health System, Inc.
RECRUITING

Baltimore, Maryland, 21204, United States
Signature Research Associates, Inc.
ACTIVE_NOT_RECRUITING

Fairlawn, Ohio, 44333, United States
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62794, United States
State University Of New York Upstate Medical University
TERMINATED

Syracuse, New York, 13210, United States
Stedman Clinical Trials
TERMINATED

Tampa, Florida, 33613, United States
Stony Brook University Hospital
TERMINATED

Stony Brook, New York, 11794, United States
Sunrise Research Institute
TERMINATED

Boca Raton, Florida, 33325, United States
Syrentis Clinical Research
WITHDRAWN

Santa Ana, California, 92705, United States
Texas Tech University Health Science Center
RECRUITING

El Paso, Texas, 79905, United States
The Center for Neuropsychiatry and Brain Stimulation (CNBS) ARC Health
TERMINATED

Cary, North Carolina, 27519, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
The University Of Texas Medical School At Houston - UT Center Of Excellence On Mood Disorders
RECRUITING

Houston, Texas, 77054, United States
The University of Utah
RECRUITING

Salt Lake City, Utah, 84108, United States
Trinity Medical
RECRUITING

Lewiston, New York, 14092, United States
UAB Huntsville Regional Medical Center
RECRUITING

Huntsville, Alabama, 35801, United States

Contact Email: •••••@•••••
UT Health Austin, Mulva Clinic for the Neurosciences
RECRUITING

Austin, Texas, 78712, United States
University Hospitals Case Medical Center
WITHDRAWN

Cleveland, Ohio, 44106, United States
University Of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of California San Diego
ACTIVE_NOT_RECRUITING

San Diego, California, 92103, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55416, United States
University of Missouri
RECRUITING

Columbia, Missouri, 65212, United States
University of New Mexico - Psychiatric Center
WITHDRAWN

Albuquerque, New Mexico, 87102, United States
University of Oklahoma School of Community Medicine
RECRUITING

Tulsa, Oklahoma, 74135, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53719, United States
Wake Forest University Health Science
WITHDRAWN

Winston-Salem, North Carolina, 27103, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
West Virginia Clinical and Translational Science Institute
WITHDRAWN

Morgantown, West Virginia, 26506, United States
dTMS Center, LCC
TERMINATED

Royal Palm Beach, Florida, 33411, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.