Brain scans reveal why some depressed patients Can't shake negative thoughts

NCT ID NCT05577247

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the brain handles negative beliefs in people with treatment-resistant depression. Researchers will use brain scans to see how these beliefs change after a single dose of ketamine. The goal is to understand why some depressed patients hold onto negative thoughts even when faced with positive evidence, and how treatment might help.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • GH Pitié Salpêtrière

    RECRUITING

    Paris, France

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