Magic mushroom compound may rebuild brain synapses in early memory loss

NCT ID NCT06041152

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can increase the density of synapses (connections between brain cells) in people with mild memory problems. Ten participants—six with amnestic mild cognitive impairment and four healthy volunteers—will receive either two doses of psilocybin or a placebo. Researchers will use brain scans to measure changes in synapse density and check if any changes are linked to better thinking and memory.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

psilocybin

What this could lead to

If it works, this could point toward a new way to treat or slow memory decline in early Alzheimer's by boosting brain connections.

What could go wrong

This is a very small pilot study with only 10 participants, so results may not apply widely. It's designed to measure brain changes, not to prove a treatment works.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Centre for Addiction and Mental Health

    Toronto, Ontario, M5T 1R8, Canada