Magic mushroom compound may rebuild brain synapses in early memory loss
NCT ID NCT06041152
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This small pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can increase the density of synapses (connections between brain cells) in people with mild memory problems. Ten participants—six with amnestic mild cognitive impairment and four healthy volunteers—will receive either two doses of psilocybin or a placebo. Researchers will use brain scans to measure changes in synapse density and check if any changes are linked to better thinking and memory.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- psilocybin
- What this could lead to
- If it works, this could point toward a new way to treat or slow memory decline in early Alzheimer's by boosting brain connections.
- What could go wrong
- This is a very small pilot study with only 10 participants, so results may not apply widely. It's designed to measure brain changes, not to prove a treatment works.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Centre for Addiction and Mental Health
Toronto, Ontario, M5T 1R8, Canada
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