Centre For Addiction And Mental Health

This pilot study tested a 4-week virtual intensive outpatient program for 63 people with moderate to severe alcohol use disorder. The program included group therapy, individual therapy, medication management, and multiple daily breathalyzer checks using facial recognition. The go…

This study tests whether adding the blood pressure medication propranolol to cognitive processing therapy (a type of talk therapy) helps people with both post-traumatic stress disorder (PTSD) and alcohol use disorder. About 48 adults aged 18 to 70 with both conditions will receiv…

This pilot study tested whether people experiencing alcohol withdrawal can be safely treated at home using telemedicine. Thirty adults who wanted to quit drinking received remote monitoring and symptom-triggered medication over three days. The goal was to see if this approach kep…

This study tested a version of cognitive behavioral therapy (CBT) that was adapted to fit the cultural background of Canadians of South Asian origin. Researchers worked with 146 adults who had depression or anxiety to see if this tailored therapy could help reduce their symptoms.…

This study tested a version of cognitive behavioral therapy (CBT) that was adapted to be more culturally relevant for Chinese youth in Ontario. 36 participants aged 12 to 21 with anxiety or depression received the therapy from community therapists. The goal was to see if this app…

This study tested a healthbot—a conversational computer program—designed to help people remember to take their varenicline (a prescription medication to help quit smoking). Researchers worked with 40 smokers in Ontario who were starting varenicline. Participants used the healthbo…

This study looked at whether creating personalized profiles for children with disruptive behavior disorders (like ADHD or oppositional defiant disorder) and their parents could help predict which therapy works best. Researchers tested two common treatments—child cognitive behavio…

This study tested whether adding the antibiotic minocycline to usual antidepressants can reduce symptoms in people with treatment-resistant depression. Over 12 weeks, 76 participants received either minocycline or a placebo. The goal was to see if the drug improves mood, anxiety,…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people with substance use disorder cut back on their drug or alcohol use. About 200 adults from an outpatient addiction program took part. Some got standard care with g…

This study compares a 6-month version of dialectical behaviour therapy (DBT) to the standard 1-year program for people with borderline personality disorder who repeatedly self-harm. Researchers want to see if the shorter therapy is just as good at reducing self-harm and is more c…

This study tested a new parenting program called ADAPT for depressed parents of children aged 6 to 10 with emotional and behavioral difficulties. The program combines emotion regulation skills with parenting techniques. The goal was to see if the program is feasible and acceptabl…

This study tested whether cytisine, a plant-based medication, is safe and helpful for quitting smoking in people who also have alcohol use disorder. Twenty adults who smoked daily and wanted to quit took part. The main goal was to see if the drug was well-tolerated and if partici…

This study tested a brief digital alcohol intervention for smokers who drink heavily. Participants enrolling in a smoking cessation program through an online portal were offered the intervention if they scored high on a drinking questionnaire. The main goal was to see how many pe…

This study tested a smartphone app called A4i designed to help people with schizophrenia manage their illness and stay connected with their care providers. 91 adults with schizophrenia or related disorders used the app for 6 months. The goal was to see if the app was practical an…

This study tested whether psilocybin, the active ingredient in magic mushrooms, can treat depression even when its psychedelic effects are blocked by another drug (risperidone). Forty-one adults with treatment-resistant depression received either psilocybin alone, psilocybin plus…

This study tested a mobile app called App for Independence-O (A4i-O) designed to support people with opioid use disorder. Fourteen adults used the app for one month while receiving outpatient treatment. The goal was to see if the app works well and is easy to use, not to measure …

This study followed 51 people with schizophrenia who were already stable on long-acting injectable antipsychotics. Over 48 weeks, researchers checked every 12 weeks whether patients stayed well or had a relapse. The goal was to see how often symptoms return when medication adhere…

This study tested a program called HOP-C that provides case management, peer support, and mental health help to youth aged 16-25 who recently moved into stable housing after being homeless. The goal was to see if this extra support helps them stay housed, find work or school, and…

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study examined 24 adolescents (ages 14-18) with and without depression to see if their brains respond differently to insulin. Participants received insulin or a placebo nasal spray, and MRI scans measured brain activity and blood flow. The goal was to understand if brain ins…

This study tested whether sending text message reminders and support to young people with psychosis after an emergency room visit helps them attend their first early psychosis appointment. 186 participants were enrolled. The goal was to see if a low-cost, youth-friendly approach …

This study tested a program called NAVIGATE, which provides coordinated care for youth and young adults (ages 14-35) who have had a first episode of psychosis. The goal was to see if NAVIGATE helps improve recovery, reduce hospital stays, and lower healthcare costs compared to st…

This completed study tested a 16-week social-emotional learning curriculum called EMPOWER in after-school programs for youth aged 11-14. Researchers wanted to see if the program was feasible and acceptable for staff and teens, and whether it improved social-emotional skills, resi…

This study looked at whether a new social-emotional learning (SEL) program could be added to a STEM after-school program for youth aged 11-14. Researchers wanted to see if the program was practical and liked by staff and kids, and if it helped improve emotional skills, resilience…

This completed study looked at how a noninvasive brain stimulation technique called TMS affects the way people with body dysmorphic disorder (BDD) process visual information. Forty adults with BDD or mild symptoms received either intermittent or continuous TMS over the parietal b…

This study looked at how nabilone, a cannabis-like drug, changes a brain enzyme called FAAH in 10 healthy adults. Participants took nabilone for one week and had brain scans before and after. The goal was to understand the drug's effect on brain chemistry, not to treat any diseas…

This study looked at how two different ways of giving a type of non-invasive brain stimulation called iTBS affect brain plasticity—the brain's ability to change and adapt. 29 healthy, right-handed adults aged 18 to 50 took part. Researchers compared a standard stimulation pattern…