Could zapping the brain help beat opioid addiction?

NCT ID NCT04379115

Recruiting now Disease control Sponsor: Case Western Reserve University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a non-invasive brain stimulation technique (tDCS plus ultrasound) to help people with opioid use disorder and chronic pain reduce drug use. Researchers will compare active stimulation to a sham (fake) treatment in 126 adults already on methadone. The goal is to see if this approach can lower cravings, pain, and opioid use.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PAIN OPIOID-USE DISORDER

Contacts and locations

Locations

Spaulding Rehabilitation Hospital - 5th Floor - Neuromodulation Center
RECRUITING

Cambridge, Massachusetts, 02138, United States
University Hospitals Cleveland Medical Center/ Dahms Clinical Research Unit
RECRUITING

Cleveland, Ohio, 44106-1716, United States
University of Illinois Health/ University of Illinois at Chicago
RECRUITING

Hinsdale, Illinois, 60612, United States

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