Could zapping the brain help beat opioid addiction?

NCT ID NCT04379115

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a non-invasive brain stimulation technique (tDCS plus ultrasound) to help people with opioid use disorder and chronic pain reduce drug use. Researchers will compare active stimulation to a sham (fake) treatment in 126 adults already on methadone. The goal is to see if this approach can lower cravings, pain, and opioid use.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Spaulding Rehabilitation Hospital - 5th Floor - Neuromodulation Center

    RECRUITING

    Cambridge, Massachusetts, 02138, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Email: •••••@•••••

  • University Hospitals Cleveland Medical Center/ Dahms Clinical Research Unit

    RECRUITING

    Cleveland, Ohio, 44106-1716, United States

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Illinois Health/ University of Illinois at Chicago

    RECRUITING

    Hinsdale, Illinois, 60612, United States

    Contact Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••