New study combines three therapies to help chronic pain patients on opioids
NCT ID NCT06442566
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing three treatments one after another for people with chronic pain who are already taking long-term opioids. First, participants try a low-dose buprenorphine patch (a safer opioid) without going through withdrawal. Then, they receive a brief cognitive behavioral therapy program for pain. Finally, some get a type of brain stimulation called TMS. The goal is to see if these steps can reduce pain, improve quality of life, and lower the risks of opioid use. The study involves 240 adults and will follow them for up to a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- buprenorphine patch, cognitive behavioral therapy, and transcranial magnetic stimulation (TMS)
- What this could lead to
- If successful, this could offer safer, more effective ways to manage chronic pain while reducing dependence on high-dose opioids.
- What could go wrong
- This is an early-phase trial (Phase 1/2) with only 240 participants, so results may not apply broadly. The interventions may cause side effects or not improve pain enough to justify changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29407, United States
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