CHRONIC PAIN
Clinical trials for CHRONIC PAIN explained in plain language.
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Hospital trial tests Pain-Free start to opioid addiction treatment
Disease control TerminatedThis study tested a new, gentler method for starting a medication called buprenorphine to treat opioid addiction and chronic pain. It compared starting with very small doses (without stopping other opioids first) against the standard method that requires patients to go through wi…
Matched conditions: CHRONIC PAIN
Phase: PHASE4 • Sponsor: Montefiore Medical Center • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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Could a blood pressure drug fix a major opioid problem?
Disease control TerminatedThis study tested whether adding the drug guanfacine to morphine could help people with chronic back or neck pain. The goal was to see if guanfacine could prevent two common problems with long-term opioid use: increased pain sensitivity (where pain feels worse) and needing higher…
Matched conditions: CHRONIC PAIN
Phase: PHASE4 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Mar 23, 2026 15:19 UTC
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First human test of new pain pill halted early
Symptom relief TerminatedThis was an early-stage study to test the safety and how the body processes a new potential pain medication called Kindolor. It involved healthy adults who received either the drug or a placebo in gradually increasing doses. The main goals were to find a safe dose and understand …
Matched conditions: CHRONIC PAIN
Phase: PHASE1 • Sponsor: Lohocla Research Corporation • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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Doctors test secret pain settings in spinal implants
Symptom relief TerminatedThis study tested whether lower-intensity settings on spinal cord stimulators could still effectively relieve chronic pain. Researchers secretly switched 10 patients with implanted devices to lower settings to see if their pain returned. The goal was to better understand how thes…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Mar 25, 2026 14:09 UTC
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Could common blood pressure drug fix opioid pain problem?
Symptom relief TerminatedThis study tested whether adding the blood pressure medication guanfacine to standard opioid treatment could reduce a specific side effect where opioids actually make people more sensitive to pain over time. It involved 120 adults with chronic back or neck pain who were already t…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Mar 23, 2026 15:17 UTC
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Home workouts vs. physical therapy: can an app ease knee pain?
Symptom relief TerminatedThis study tested if a digital home exercise program could work as well as standard physical therapy for people with chronic knee osteoarthritis pain. Participants were randomly assigned to either use the SimpleTherapy app at home or receive traditional physical therapy for six w…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Symptom relief
Last updated Mar 16, 2026 15:26 UTC
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Can changing your thoughts about pain curb opioid cravings?
Knowledge-focused TerminatedThis study aimed to understand if a thought pattern called 'pain catastrophizing'—where people focus on and fear the worst about their pain—causes cravings for prescription opioid painkillers. Researchers worked with 93 adults who had chronic pain and were taking opioids long-ter…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Study probes why some heart patients suffer Long-Term pain after surgery
Knowledge-focused TerminatedThis study aims to understand how many patients experience acute and chronic pain after a specific type of heart rhythm surgery called hybrid ablation. Researchers will survey patients who had the surgery at least three months ago to learn about their pain levels and what pain ma…
Matched conditions: CHRONIC PAIN
Phase: NA • Sponsor: Universitair Ziekenhuis Brussel • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:35 UTC