Can a blood pressure drug ease opioid pain side effects?
NCT ID NCT02192398
First seen Nov 06, 2025 · Last updated May 17, 2026 · Updated 25 times
Summary
This small study looked at whether adding guanfacine (a blood pressure medicine) to opioid painkillers could reverse a condition called opioid-induced hyperalgesia, where opioids actually make pain worse. The trial planned to enroll 8 adults with chronic neck or back pain who were already taking stable doses of opioids. The study was terminated early, so results are limited.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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MGH Center for Translational Pain Research
Boston, Massachusetts, 02114, United States
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