CHRONIC PAIN

This study is testing whether a few doses of ketamine, given alongside guided therapy sessions, can help people with treatment-resistant depression. Researchers want to see if this combination changes brain activity in ways that reduce depression symptoms and improve emotional fl…

This study is testing a 9-week online program designed to help veterans who have both chronic pain and opioid addiction. The program provides personalized weekly feedback and daily check-ins to help manage pain and support recovery while participants continue their standard medic…

This study is testing a new, intensive brain stimulation program designed to help Veterans who are struggling with both post-traumatic stress disorder (PTSD) and chronic pain at the same time. Thirty Veterans will receive multiple short brain stimulation sessions each day for one…

This study is testing a new 6-week program designed to improve how healthcare teams work together to manage chronic pain. It will involve 66 patients with long-term pain at three primary care clinics in Spain. The goal is to see if this more organized, team-based approach is prac…

This study aims to find out which type of surgical stitch works better for closing the abdominal wall after major surgery. It will compare a dissolving stitch with a permanent one in 156 patients in Pakistan. The main goal is to see which stitch leads to fewer hernias, infections…

This study is testing if customizing magnetic brain stimulation to a person's unique brain activity works better for chronic pain than the standard one-size-fits-all approach. Researchers will scan the brains of 90 people with chronic pain to guide where to apply the stimulation.…

This study is testing a new video series called 'Reclaim Your Day' designed to help older adults manage chronic pain. The videos feature real people sharing their personal stories of living with pain and teach coping strategies. Researchers will compare the video series to standa…

This study is testing whether a smartphone app that provides personalized music can help people with HIV manage their chronic pain. 60 participants will be randomly assigned to either use the music app daily for 3 months or receive educational materials about pain. The main goal …

This study is testing whether listening to music can help people with long-term pain feel less anxious and experience less pain when they undergo a specific pain treatment procedure. About 110 adults scheduled for these procedures will be randomly assigned to either listen to the…

This study is collecting information from people who receive an FDA-approved spinal cord stimulator to manage severe, long-term pain. Researchers want to see how well the device works, if patients can learn to adjust it themselves, and how it affects pain, sleep, mood, and daily …

This study is designing and testing a personalized coaching program to help U.S. military Veterans with long-term muscle and bone pain. The goal is to help Veterans create and stick to their own self-care plans to manage their pain better. Researchers will first gather feedback f…

This small pilot study is testing whether a virtual reality (VR) program with an artificial intelligence (AI) coach is a practical and acceptable tool for patients. It's designed for people who have both chronic pain and issues with opioid misuse. The single 45-minute VR session …

This study is testing whether a four-week educational program on good sleep habits can improve sleep quality and reduce pain for adults with chronic migraine or lower back pain. Researchers will enroll 100 participants, who will learn sleep hygiene techniques and complete questio…

This study is testing an online program called EmpowerSpine, designed to help people with spinal cord injuries manage their chronic pain. Researchers want to figure out which parts of the program—like coaching, peer support, or follow-up sessions—work best to reduce pain and impr…

This study is testing whether simply imagining a specific back exercise can help reduce pain and improve movement in people with chronic low back pain. Researchers will guide 40 participants through a brief mental exercise session where they visualize performing a back extension …

This study aims to see if personalized lifestyle coaching helps older adults better manage long-term muscle and joint pain. Researchers will compare a group receiving coaching sessions to a group receiving usual care. They will measure changes in pain levels, daily function, stre…

This study is testing a non-drug treatment called transcranial electrical stimulation (tES) for people who have both depression and long-term pain. Over 240 participants will be randomly assigned to receive one of four types of gentle brain stimulation or a sham (fake) treatment …

This study is testing whether breathing pure oxygen in a special pressurized chamber can help people with severe, long-term pain from Complex Regional Pain Syndrome (CRPS). It will involve 60 participants, with one group starting the therapy right away and another group waiting a…

This study is testing whether a combined exercise program can reduce chronic pain in postmenopausal women. Researchers will look at how exercise might work by improving the body's insulin sensitivity and reducing inflammation. The goal is to provide evidence for exercise as a non…

This study is testing a new way to manage severe pain by having specially trained medical teams perform targeted pain-relief injections and nerve blocks right in a patient's home. It aims to see if this approach is safe, effective, and can improve comfort and quality of life for …

This study is testing a program designed to help people with long-term muscle and joint pain manage their condition better. It teaches coping skills, safe movement, and ways to change unhelpful thoughts about pain. Researchers will compare this program to usual care to see if it …

This is a small pilot study to test an 8-week online therapy program designed to help people with chronic pain and emotional distress like anxiety or depression. The program teaches skills like mindfulness and acceptance to help manage pain and improve daily functioning. Particip…

This study is testing whether a virtual reality (VR) program can be a useful tool for teaching people with chronic pain about their condition. Fifty adults with chronic pain will use a VR headset for six weeks to learn about pain science and coping strategies. The main goal is to…

This study is testing whether a safe, non-drug brain stimulation technique can help reduce chronic pain in military veterans. Up to 100 veterans receiving mental health care will use a device that delivers a mild electrical current to the brain for 20 minutes daily over two weeks…

This study will observe if ozone therapy helps improve quality of life for people with chronic pain and other symptoms that haven't responded to standard treatments. It will follow 120 patients referred to a pain clinic for this therapy between 2026 and 2029. Researchers will tra…

This is a small pilot study to see if a new group music therapy program is practical and well-liked by people with long-term pain. The program mixes in-person and online sessions. The main goal is to check if people can stick with the program and complete the required activities,…

This study aims to see if adding digital tools to standard pain management helps people feel better. 80 adults with chronic low back pain will be randomly assigned to either receive standard care or standard care plus a smartwatch and mobile app for tracking. The goal is to find …

This study is testing a device called Scrambler Therapy to see if it can safely reduce nerve pain in children and young adults with cancer that has spread to their bones. Participants will have 5 to 10 short therapy sessions over a couple of weeks. The main goal is to see if the …

This study aims to find out which type of talk therapy works better for veterans living with long-term back or neck pain. Researchers will compare a newer approach called Pain Reprocessing Therapy (PRT) against the standard Cognitive Behavioral Therapy (CBT) and against the usual…

This study is testing a new group training program for parents of children with chronic pain. The main goal is to see if the program is practical and well-liked by families. Researchers will also check if it helps reduce the child's pain and improves their ability to do daily act…

This study is testing whether a 6-week program using a free mind-body mobile app along with gentle, guided movement exercises can help people manage chronic pain. Researchers will enroll 100 adults who have experienced pain for at least six months. The main goal is to see if this…

This study is testing if adding an online educational program about how pain works in the brain and body to standard physical therapy helps people with long-term low back pain. It will involve 60 adults who have had back pain for over 3 months. The goal is to see if this combined…

This study aims to find safer, non-addictive alternatives to opioid painkillers for people with chronic pain and circulatory issues. It will compare the effectiveness of cannabis-based products against traditional opioid medications. Researchers will enroll 1,000 participants and…

This study aims to translate an English questionnaire about pain-related thoughts and beliefs into Turkish and test how well it works. Researchers will ask 210 Turkish-speaking adults with chronic pain to complete the questionnaire and other surveys in a single session. The goal …

This study aims to understand why combat-related brain injuries often lead to long-term chronic pain. Researchers will follow 100 veterans with recent mild-to-moderate brain injuries for six months, tracking their pain levels, psychological state, and physical function. The goal …

This study aims to understand if a single session of intense aerobic exercise can temporarily reduce pain sensitivity in young people, both with and without chronic pain conditions. Researchers will measure pain responses before and after exercise in 66 youth participants. The go…

This study aims to understand if people with chronic jaw pain (temporomandibular disorders) feel thin foils between their teeth differently than healthy people. Researchers will compare 80 participants - half with jaw pain and half without - by placing various thicknesses of spec…

This study aims to understand why some people develop long-lasting pain after a serious limb fracture from a major accident, while others recover. Researchers will follow 450 patients with multiple injuries for six months after their accident, asking them about their pain levels.…

This study aims to understand how what people know about their pain and how they cope with it relates to their sexual function. It involves 50 adults with chronic pelvic pain who will fill out questionnaires one time. The goal is to gather information to help guide future educati…

This study aims to understand what side effects chronic pain patients find most unacceptable when weighed against pain relief from their medications. Researchers will survey 200 adults with chronic pain about their experiences with common medication side effects like drowsiness, …

This study aims to understand if developing a blood clot (venous thromboembolism) after a major arm or leg injury increases a person's chances of having long-lasting, significant pain. Researchers will follow 150 adults with serious limb injuries for six months, comparing pain le…

This study aims to understand if a person's emotional intelligence is linked to chronic jaw pain. Researchers will compare 88 people with painful jaw disorders to a group without chronic pain. Participants will fill out questionnaires about their emotions, anxiety, and coping ski…

This study aims to gather real-world information on how prescribed cannabis-based products work for people in Brazil. Researchers will follow 384 patients for six months to see if these treatments improve quality of life and help with conditions like chronic pain, anxiety, and de…

This study looks back at the medical records of about 200 patients with Complex Regional Pain Syndrome (CRPS) to see which pain-relief treatments were used first and how well they worked. The goal is to learn from past experience to help guide future treatment choices. It does no…

This study aims to understand and predict who develops long-term pain after getting a pacemaker or similar heart device. Researchers will follow 180 patients for a year, measuring their pain and quality of life. The goal is to use this data to build an artificial intelligence too…

This study aims to understand how mindfulness meditation and therapeutic hypnosis work in the brain to help older adults manage chronic pain. Researchers will use brain scans and surveys to compare these approaches against simple story listening in 375 participants aged 60+. The …

This study aims to learn if a short educational session about the science of pain can improve memory and change how people with long-term pain perceive their bodies. Researchers will enroll 50 adults who have had chronic pain for over a year. Participants will take memory and pai…