CHRONIC PAIN

This study tests a one-week, non-invasive brain stimulation program for 30 veterans who have both PTSD and chronic pain. All participants receive the active treatment (no placebo) with up to 6 short sessions per day. Researchers will check if symptoms improve right after treatmen…

This study tests a non-drug treatment called transcranial electrical stimulation (tES) for people who have both depression and chronic pain. 240 adults will receive one of four types of brain stimulation (or a sham) for 2 weeks. Researchers will measure changes in pain and mood t…

This study explores whether a 6-week virtual reality (VR) program can help 50 adults with chronic pain learn about pain science and management. Participants will use VR to watch educational content and do guided exercises. The goal is to see if this approach is feasible, acceptab…

This study looks at whether one session of intense aerobic exercise can lower pain sensitivity in teens with chronic pain. Researchers will compare pain responses in 66 youth with and without chronic pain before and after treadmill exercise. If effective, exercise could become a …

This study tests whether a mind-body mobile app combined with a guided gentle movement program can help people with chronic pain feel better. About 100 adults aged 19 to 75 with pain lasting at least 6 months will use the app and do weekly movement sessions for 6 weeks. Researche…

This study tests if ketamine, given alongside psychotherapy, can help people with depression that hasn't improved with other treatments. About 25 adults will receive 1-2 doses of ketamine and 3-4 therapy sessions. Researchers will use brain scans and surveys to see if the treatme…

This small pilot study tests an internet-based therapy (Acceptance and Commitment Therapy) for adults with chronic pain and emotional distress like anxiety or depression. About 5-10 participants will use a secure online platform with exercises and have phone support from a psycho…

This study tests a new approach for people with low back pain who find it hard to do physical exercises. Instead of moving, participants will imagine doing specific back extension exercises. The goal is to see if this mental practice can reduce pain, improve movement, and help sy…

This study tests whether a 10-week virtual mindfulness program can improve quality of life for people with endometriosis-related chronic pelvic pain. Researchers will enroll 124 adults aged 18-50 with a diagnosis of endometriosis. Participants will attend online mindfulness sessi…

This study tests a group program for adults with long-term back pain. Participants learn about pain, healthy habits, and emotional tools, and do guided exercises. The goal is to improve physical function, reduce fear of movement, and boost quality of life. Researchers will check …

This study looks at whether teaching people with migraine or chronic lower back pain about good sleep habits can help them sleep better and feel less pain. About 100 adults will take part, learning sleep hygiene tips and using them at home for four weeks. There is no medicine inv…

This study tests a personalized coaching program for Veterans with long-term muscle or joint pain. The goal is to help them create and stick with a self-care plan that fits their needs. About 30 Veterans will take part to see if the program is practical and helpful.

This study tests an online program called EmpowerSpine for people with spinal cord injury who have chronic pain. The program teaches pain biology, daily coping strategies, and resilience skills. Researchers will test which parts of the program—like coach guidance, peer support, o…

This study tests a device called Scrambler Therapy to see if it can safely reduce nerve pain in children with cancer that has spread to the bone. About 70 children will receive the non-invasive treatment, and researchers will measure changes in pain intensity and medication use. …

This study tests a wearable ultrasound device that targets nerves to reduce chronic pain without medication or surgery. About 90 adults with nerve-related pain will attend a single visit to receive ultrasound stimulation and report their pain levels. The goal is to see if the dev…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with severe complex regional pain syndrome (CRPS), a chronic pain condition. About 60 adults with CRPS Type I will receive either the oxygen treatment or standard c…

This study looks at two types of nerve blocks given before mastectomy to see which one better prevents chronic pain three months after surgery. About 132 adults having a mastectomy will be randomly assigned to receive either an erector spinae block or a paravertebral block. Resea…

This study tests whether using a smartwatch and a mobile app, along with standard care, can help adults with chronic low back pain manage their symptoms better. Eighty adults will be split into two groups: one gets standard treatment alone, the other also uses a smartwatch and ap…

This study tests whether giving pain-relief procedures—like nerve blocks—at home can help adults with chronic, cancer, or nerve pain. About 100 people in a home hospital program will receive ultrasound-guided treatments at home instead of in a clinic. The goal is to see if this a…

This study will follow 120 adults with chronic pain, nerve damage from chemotherapy or radiation, or slow-healing wounds who are referred for ozone therapy. Researchers want to see if adding ozone treatments improves quality of life and reduces symptoms. The study is observationa…

This study looks at whether a 24-week Tai Chi program can help older adults (65+) who have chronic pain in multiple body areas and are at risk of falling. Researchers will measure pain, thinking skills, mobility, fear of falling, and actual falls. The goal is to see if Tai Chi ca…

This study tests whether sleeping with a weighted blanket can reduce pain and improve sleep and daily function in adults with chronic pain. About 44 participants will use a blanket weighing roughly 10% of their body weight every night for five weeks. The goal is to see if this si…

This study tests a digital treatment program that veterans with opioid use disorder and chronic pain can use at home. The goal is to see if it helps reduce how much pain interferes with daily life and improves overall function. About 250 veterans who are already on buprenorphine …

This study tests whether giving a single dose of ketamine during open-heart surgery can reduce chronic pain that sometimes lasts for months after the operation. About 100 adults having planned heart surgery will be randomly assigned to receive either ketamine or a placebo. Resear…

This study tests if listening to a short audio-guided mindfulness exercise can help reduce pain for people waiting to see an orthopedic doctor. About 300 adults will be randomly assigned to different lengths of mindfulness practice. The goal is to see if even a brief session can …

This study aims to find safer, non-addictive alternatives to opioids for managing chronic pain and circulatory disorders. Researchers will compare cannabis and opioid treatments in 1,000 participants, using nerve testing to measure changes in pain and swelling. The goal is to hel…

This study looks at whether playing music before, during, and after pain procedures can lower anxiety and pain in adults with chronic pain. About 110 participants will either listen to their own chosen music or receive standard care. Researchers will measure anxiety, pain-related…

This study will test a psychological treatment for chronic pain that is adapted to the culture of American Indian and Alaska Native peoples. About 30 adults with chronic pain will take part to see if the program is acceptable and practical. The goal is to gather information neede…

This small pilot study will test whether a one-time, 45-minute virtual reality (VR) session guided by an artificial intelligence (AI) coach is practical and helpful for people with chronic pain who also misuse opioids. Fifteen participants will use a VR headset to talk to the AI,…

This study is testing a new smartphone app called Harmonized Healing, which uses personalized music to help people with HIV manage their chronic pain. Researchers want to see if using the app is practical and acceptable for participants over three months. The study will also comp…

This study is testing a new video series called 'Reclaim Your Day' designed to help older adults manage chronic pain. The videos feature real patients sharing their stories and teaching coping strategies. Researchers will enroll 100 adults aged 55+ with chronic musculoskeletal pa…

This study looks at how people with chronic pain experience pleasant touch and how often they receive it in daily life. Researchers want to see if these experiences are linked to pain sensitivity and body awareness. About 100 adults referred to a pain clinic will fill out online …

This study looks at how adults with chronic pelvic pain understand their pain and cope with it, and how these factors relate to their sexual function. Researchers will ask 50 participants to fill out questionnaires about pain knowledge, coping strategies, and sexual health. No tr…

This study looks at 180 adults getting a pacemaker or defibrillator for the first time. Researchers will track pain and quality of life for a year, then use that data to build an AI system that predicts who is at risk for long-term pain. The goal is to help doctors prevent chroni…

This study tests whether a special band-aid (A-Band) and a smartwatch can accurately measure pain in women with chronic pain. About 115 women will wear the devices for a week while reporting their pain. The goal is to see if these tools can replace subjective pain scales with obj…

This study tests a new way of organizing care for people with long-term pain who are seeing a physical therapist. The goal is to see if a personalized care model, called GAP-421, can improve how well different healthcare providers work together for each patient. About 66 adults w…

This study watches 220 adults getting knee replacements to see if a short burst of pain after nerve block wears off (rebound pain) is linked to chronic pain months later. No new treatments are tested—just standard care and pain tracking. Results may help doctors predict who needs…

This study looks at whether people with jaw pain (temporomandibular disorder, or TMD) have a harder time feeling thin foils between their teeth compared to healthy people. Researchers will test 80 adults—40 with TMD and 40 without—by placing foils of different thicknesses between…

This study compares two common stitch materials (Polyglactin and Polypropylene) used to close the abdominal wall after surgery. The goal is to see which one leads to fewer hernias, infections, and less long-term pain. About 156 adults in Pakistan having belly surgery will take pa…

This study asks 200 adults with chronic pain which side effects of pain medications they find least acceptable compared to the pain relief they get. Participants will rate how much they value avoiding issues like drowsiness, nausea, or addiction versus getting pain relief. The re…

This study is a research registry for 40 adults with long-lasting, severe pain who plan to use an FDA-approved spinal cord stimulator (Evoke System). The goal is to collect data on how well the device works, how easy it is to program, and how it affects pain, sleep, mood, and dai…

This study follows 450 people who have had a serious injury with at least one broken bone in a limb. Researchers want to find out which patients are more likely to develop long-term pain. Participants fill out questionnaires about their pain at the start, then again at 3 and 6 mo…

This study aims to translate the Pain Metacognitions Questionnaire into Turkish and check if it is a reliable tool. About 210 adults with chronic non-cancer pain will fill out surveys once. The goal is to provide a valid way to measure pain-related thoughts and beliefs in Turkish…

This study looks at whether a short lesson about how pain works (called Pain Neuroscience Education) can help memory and body awareness in adults who have had chronic pain for over a year. Fifty participants will take memory tests and draw where they feel pain before and after a …

This study follows 100 adults who have had a combat-related traumatic brain injury (TBI) to learn why some develop long-term chronic pain. Participants join within 14 days of injury and are tracked for 6 months. Researchers will check pain levels, mental health, and physical fact…

This study looks at whether people who develop blood clots after a serious arm or leg injury are more likely to have long-term pain. Researchers will follow 150 adults for six months after their injury. The goal is to better understand the connection between clots and ongoing pai…

This study looks back at medical records of 200 adults with Complex Regional Pain Syndrome (CRPS) to see which pain treatments doctors use first and how well they work. The goal is to find patterns that could help guide better treatment choices. No new treatments are given; the s…

This study looks at whether emotional intelligence—the ability to understand and manage emotions—can influence chronic orofacial pain. Researchers will compare 88 adults with and without temporomandibular disorder (TMD) using questionnaires. The goal is to find new ways to improv…

This study looks at whether a combined exercise program can reduce chronic pain in postmenopausal women. Researchers think insulin resistance might be a key factor. They will measure pain, metabolism, and inflammation in 50 women who are not on hormone therapy or exercising regul…