New pill could ease chronic back pain without surgery

NCT ID NCT07641504

Not yet recruiting Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This Phase 2 trial tests an oral drug called LY4065967 in 150 people with chronic low back pain lasting at least 3 months. Half will get the drug, half a placebo, to see if it safely reduces pain and improves daily function. The study is not yet recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LY4065967 (oral drug)
What this could lead to: If successful, this could provide a new oral treatment option for people with chronic low back pain, potentially reducing pain and improving sleep.
What could go wrong: This is an early Phase 2 trial with only 150 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Low Back Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PAIN LOW BACK PAIN

Contacts and locations

Locations

Accel Research Sites - DeLand Clinical Research Unit

DeLand, Florida, 32720, United States
Altoona Center For Clinical Research

Duncansville, Pennsylvania, 16635, United States
Arizona Research Center

Phoenix, Arizona, 85053, United States
Artemis Institute for Clinical Research

Riverside, California, 92503, United States
Artemis Institute for Clinical Research

San Diego, California, 92123, United States
Bradenton Research Center, Inc.

Bradenton, Florida, 34205, United States
CMR of Greater New Haven

Hamden, Connecticut, 06517, United States
Central Research Associates

Birmingham, Alabama, 35205, United States
Charter Research - Lady Lake

The Villages, Florida, 32162, United States
Clinvest Research LLC

Springfield, Missouri, 65807, United States
Conquest Research

Winter Park, Florida, 32789, United States
DelRicht Research

New Orleans, Louisiana, 70115, United States
DelRicht Research

Tulsa, Oklahoma, 74133, United States
Desert Oasis Healthcare Medical Group

Palm Springs, California, 92262, United States
FutureSearch Trials of Neurology

Austin, Texas, 78731, United States
Great Lakes Research Group, Inc.

Bay City, Michigan, 48706, United States
K2 MEDICAL Research THE VILLAGES

Lady Lake, Florida, 32159, United States
K2 Medical Research ORLANDO

Maitland, Florida, 32751, United States
Lillestol Research

Fargo, North Dakota, 58104, United States
Lucida Clinical Trials

New Bedford, Massachusetts, 02740, United States
META Medical Research Institute

Dayton, Ohio, 45432, United States
MedVadis Research Corporation

Waltham, Massachusetts, 02451, United States
Merritt Island Medical Research, LLC

Merritt Island, Florida, 32952, United States
New Horizon Research Center

Miami, Florida, 33165, United States
North Georgia Clinical Research

Woodstock, Georgia, 30189, United States
Northwest Clinical Research Center

Bellevue, Washington, 98007, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ponce Medical School Foundation Inc.

Ponce, 00716, Puerto Rico
Precision Clinical Research

Sunrise, Florida, 33351, United States
Rainier Clinical Research Center

Renton, Washington, 98057, United States
Re:Cognition Health - Fort Worth

Fort Worth, Texas, 76104, United States
Renstar Medical Research

Ocala, Florida, 34470, United States
Rochester Clinical Research, LLC

Rochester, New York, 14609, United States
StudyMetrix Research

City of Saint Peters, Missouri, 63303, United States
Suncoast Clinical Research, Inc.

New Port Richey, Florida, 34652, United States
Suncoast Research Group

Miami, Florida, 33135, United States
Synexus Clinical Research US, Inc.

Phoenix, Arizona, 85020, United States

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