CHRONIC PAIN

This study tests two approaches to help people with chronic pain and opioid use disorder: telemedicine with collaborative management alone, or combined with a self-management program. About 259 adults will participate to see if these methods improve pain and reduce opioid misuse.…

This study aimed to test a closed-loop spinal cord stimulation system to reduce muscle stiffness (spasticity) and pain in people who had a stroke or brain injury. The trial was withdrawn before enrolling any participants, so no results are available. The approach was intended to …

This study explores whether low-intensity focused ultrasound (LIFU) can temporarily change brain activity to reduce chronic pain. About 80 adults with moderate-to-severe pain lasting at least 3 months will receive noninvasive brain stimulation and rate their pain during heat test…

This study tests whether spinal cord stimulation (SCS) can reduce chronic limb pain caused by diabetic peripheral neuropathy. About 28 adults with diabetes and long-lasting leg or foot pain will receive an SCS device and be followed for 12 months. The main goal is to see how much…

This study tests whether a nasal spray containing oxytocin, a natural body chemical, can help reduce pain and improve daily function in people with chronic pain. About 336 adults with nerve, muscle, or pelvic pain will try three different sprays (low-dose oxytocin, medium-dose ox…

This study looks at how well a closed-loop spinal cord stimulator works for people with long-term pain. Researchers will track pain levels and quality of life in 25 adults who have had pain for at least 6 months. The device automatically adjusts stimulation to help reduce pain.

This study compares two community-based programs for adults with long-term back or neck pain. One program teaches mind-body skills like mindfulness and cognitive behavioral techniques, while the other focuses on general health and well-being. Participants attend nine weekly sessi…

This study tests whether non-drug treatments like physical therapy and counseling, delivered via telehealth, can help people with chronic back pain feel better and rely less on opioids. About 500 adults from community health centers in Utah will take part. The goal is to find pra…

This study is testing a special spinal cord stimulator that automatically adjusts its signals to better control long-term pain in the back, arms, or legs. About 70 adults with severe chronic pain will use the device for several years. Researchers will track how much pain decrease…

This study compares two virtual symptom management programs for adults aged 60+ who have chronic pain and early cognitive decline. Over 260 participants will try either Active Brains 1 or 2, focusing on physical, mental, and emotional health. Researchers will track improvements i…

This study compares doing electrotherapy and neck exercises at home via video calls versus going to a clinic for the same treatment. One hundred adults with chronic neck pain will be split into two groups and treated for 8 weeks. Researchers will measure pain, disability, and qua…

This study tests whether a simple education and self-management program with home exercises can reduce pain and improve daily function in adults with long-lasting jaw pain (TMD) as effectively as more intensive hands-on physiotherapy. Forty adults aged 18 to 65 with jaw pain for …

This study tests a safe, noninvasive brain stimulation technique (transcranial direct current stimulation) that people can use at home to relieve chronic pain. It involves 34 adults with rheumatoid arthritis who still have significant pain despite low inflammation. The goal is to…

This study tests whether a digital version of cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in 140 adults with chronic pain and insomnia. Participants receive either the digital CBT-I program or basic sleep hygiene education. The goal is to f…

This study tests whether two types of gentle brain stimulation—transcranial direct current stimulation (tDCS) and transcranial ultrasound (TUS)—can reduce pain and improve daily function in people with long-term low back pain. Researchers will compare active stimulation to a sham…

This study compares two types of nerve blocks—interscalene and suprascapular—for controlling pain after arthroscopic shoulder surgery. The goal is to see which provides better pain relief, reduces the need for strong painkillers, and lowers the risk of long-term chronic pain. The…

This study tests a new program called PhYoMind that combines physiotherapy, yoga, and mindfulness for people with fibromyalgia. 40 adults will either do this program or just home exercises for 8 weeks. The goal is to see if the combined approach reduces disability, pain, stress, …

This study compares a multidisciplinary treatment (combining different specialists) with standard care for women suffering from chronic vulvar pain (vulvodynia) for at least 3 months. The goal is to see if the team approach reduces pain better than usual care. 106 women aged 18 a…

This study tests a program called RESET, led by community health workers, to help older adults in Detroit improve their physical and mental well-being. About 456 African American adults aged 50 and older with symptoms like depression, anxiety, chronic pain, or loneliness will tak…

This study looks at how well a group program for chronic pain works in health centers that serve low-income patients. The program combines medical advice, gentle movement, and mind-body techniques. Researchers will train clinic staff and track how many patients join, how much it …

This study tests whether a single session of a non-invasive brain stimulation technique called cerebellar tDCS can reduce pain and change brain activity in women with fibromyalgia. The trial involves 92 right-handed women aged 18-65 with confirmed fibromyalgia and moderate to sev…

This study looks at whether adding a special type of massage therapy to regular mental health care can help refugees and asylum seekers who survived torture or war. About 50 people will take part, with some getting massage plus standard care and others getting standard care alone…

This study tests whether gentle sound waves aimed at the brain can help people with chronic pain feel less discomfort. About 80 adults will get a noninvasive treatment called low-intensity focused ultrasound while their pain responses are measured. The goal is to see if this appr…

This study tests a spinal cord stimulator that delivers pain relief without the usual tingling sensation. It involves 177 adults with long-term back and limb pain. The goal is to see if this new therapy can cut pain by at least half within three months.

This study watches 100 adults with chronic pain who get ketamine infusions at Stanford. Researchers track pain levels and overall well-being to see who improves and what traits predict success. The goal is to better understand which patients benefit from this treatment.

This study compares two types of spinal cord stimulation—high frequency and burst—to see which provides better long-term pain relief for people with chronic back or leg pain. About 7 adults who are candidates for spinal cord stimulation will be randomly assigned to one of the two…

This early study tests a new approach to deep brain stimulation for people with severe, treatment-resistant chronic pain from stroke, spinal cord injury, or phantom limb. Instead of constant stimulation, the device delivers electrical pulses only when the brain senses high pain s…

This study compares two exercise programs for older adults living in residential care: short, frequent 'exercise snacks' versus longer, structured sessions. About 75 people aged 65+ will be randomly assigned to one program for 12 weeks. Researchers will measure changes in physica…

This study tests a combined therapy (Acceptance and Commitment Therapy plus Mindfulness-Based Relapse Prevention) for veterans with chronic pain who are also being treated for opioid use disorder. About 157 veterans will take part, comparing the new therapy to standard education …

This study is testing a new, non-invasive device that delivers gentle vibrations to the belly, back, or head to help people with chronic pain conditions like pelvic pain, abdominal pain, low back pain, and migraine. About 50 adults will try the device or a placebo to see if it sa…

This study explores whether listening to jazz music combined with mindfulness practices can reduce chronic pain and anxiety in adults. Researchers aim to provide a non-addictive alternative to opioids. The trial involves 90 participants with chronic pain and moderate to severe an…

This study aimed to see if a device called Buzzy (a vibrating ice pack) could reduce pain during IV insertion in adults with chronic pain who receive lidocaine infusions. Participants would have rated their pain and satisfaction. However, the study was withdrawn before enrolling …

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study tests whether using a green LED light at home for 2 hours each day can reduce chronic pain and improve quality of life. About 55 adults with conditions like fibromyalgia or nerve pain from HIV or chemotherapy will take part. The goal is to see if this safe, drug-free a…

This study tests whether adding a gentle, non-invasive brain stimulation technique called TMS to a three-week intensive rehab program can help teens with severe chronic pain feel better. Researchers will measure changes in pain, brain activity, and mental health in 25 youth aged …

This study is testing whether a tailored yoga coaching program can help reduce chronic pain in people with lupus (SLE). Researchers are enrolling 15 adults with stable lupus medications and ongoing pain to see if the program is practical and helpful. The goal is to improve pain m…

This study tests if special colored light shown to the eyes can lower pain in people with chronic low back pain or fibromyalgia. Sixty adults will wear a light device for 2 hours daily over 5 days. The goal is to see if this light therapy is feasible and reduces pain intensity.

This study tests whether a one-time pain relief skills session, called Empowered Relief, can lower the chance of long-term pain after a cesarean delivery. Researchers will enroll 60 women who still have moderate to severe pain 6 weeks after their C-section. Participants will lear…

This study tests two approaches to help people with opioid use disorder and chronic pain who are taking buprenorphine. One approach is a pain self-management program with coaching and peer support. The other allows patients to adjust their buprenorphine dose based on their pain l…

This study tests a mindfulness program called MORE to see if it can help people with long-term cancer pain. Researchers will enroll 76 adults who have had cancer and still have pain for at least 3 months. The goal is to see if learning to focus on the present moment can reduce pa…

This trial gave a single patient multiple infusions of stem cells (HB-adMSCs) to treat long-term muscle and joint pain. The goal was to reduce pain and improve quality of life over about 32 weeks. The study is no longer available.

This study tests whether a nurse care management program can help 450 rural adults with chronic pain feel better and function more in daily life. The program includes care coordination, cognitive behavioral therapy, and a remote exercise program. Participants must live in a rural…

This study tests whether a 12-week Pain Self-Management (PSM) program helps people with chronic pain and opioid misuse or opioid use disorder (OUD) manage pain better and stay engaged in their OUD treatment. About 204 adults from primary care clinics will either take part in PSM …

This study tests a new, organized care plan for adults with chronic pain. It compares the new plan to usual care at pain clinics. The goal is to see if the new plan improves pain, daily function, and satisfaction with care.

This study compares a single dose of ketamine to a placebo (saline) given during sedation with propofol in 40 adults with chronic pain and depression. The goal is to see if ketamine works better than placebo under these conditions. Participants will be sedated, receive the infusi…

This study tests a physiotherapist-led program for teens and young adults (ages 12-25) who have had muscle or joint pain for at least 3 months. The program uses gradual exposure to physical activity to help them become more active and feel less distressed. 35 participants are inv…

This study tests whether a smartphone app that guides slow, paced breathing can help reduce migraine attacks. Thirty adults with chronic migraine will use the app for 10 minutes daily over 8 weeks. The goal is to see if the app is easy to use and if it lowers headache frequency a…

This study compares two types of acupuncture (personalized electro-acupuncture and auricular-acupuncture) with usual care for treating chronic pain. About 360 adults with musculoskeletal pain or fibromyalgia will be assigned to one of three groups. The goal is to see which approa…

This study tests whether yoga can reduce nerve pain (peripheral neuropathy) caused by chemotherapy. About 227 cancer survivors will either take yoga classes, attend educational sessions, or continue their usual care. Researchers will measure pain levels, balance, fall risk, and q…

This study tests whether gentle electrical and ultrasound brain stimulation can reduce pain and improve daily function in people with knee osteoarthritis. About 64 adults with chronic knee pain will receive either real or fake (sham) stimulation to see if it lowers pain scores. T…

This study tests a small implanted device that sends mild electrical pulses to nerves to relieve chronic pain from nerve injury or surgery. About 185 adults with long-lasting pain in the back, shoulder, knee, or foot will either get the implant plus usual care or usual care alone…

This study tests whether a digital health program (Hinge Health) plus a wearable pain relief device (Enso) can reduce pain and improve function in people with chronic low back pain. About 196 adults with back pain for at least 3 months will be randomly assigned to either the digi…

This study tests Pain Reprocessing Therapy (PRT), a type of talk therapy that teaches people to reinterpret pain signals, for chronic widespread pain and fibromyalgia. Fifteen adults will track their pain, mood, sleep, and activity multiple times daily during a baseline period an…

This study tests a small implanted device that sends mild electrical pulses to nerves to treat chronic pain from nerve injury or surgery. About 89 adults with ongoing pain in the back, shoulder, knee, or foot will either get the implant plus usual medical care or usual care alone…

This study tests a new spinal cord stimulator that listens to your nerves and adjusts its signals in real time to better treat chronic pain in the back, legs, or trunk. About 250 adults with long-lasting pain will try the device. The goal is to see if this smart system improves p…

This study tests a combination of pain neuroscience education and behavioral graded activity in 122 breast cancer survivors who have chronic pain. Participants in the intervention group attend six sessions to learn about pain and gradually increase activity, while the usual care …

This study tests whether a spinal cord stimulator (BurstDR) can reduce chronic pain in people with diabetic neuropathy. Twenty adults with long-lasting, severe leg pain who haven't gotten relief from standard medicines will try a temporary stimulator for one week. If their pain d…

This study tests a treatment that combines two therapies—Acceptance and Commitment Therapy (ACT) and Mindfulness-Based Relapse Prevention (MBRP)—to help people with both chronic pain and opioid use disorder. About 160 adults already stable on buprenorphine will be randomly assign…

This study looked at whether taking a probiotic supplement for 8 weeks could lower inflammation and ease pain in teenagers (ages 13-17) who have chronic pain and a body mass index at or above the 85th percentile. Researchers measured changes in a blood marker for inflammation and…

This study looks at whether adding monthly booster contacts to a short course of cognitive behavioral therapy helps people with chronic pain manage their symptoms longer. About 716 military health system beneficiaries with ongoing pain will be randomly assigned to receive the the…

This study tests whether adding 6 weeks of app-based physical exercise and mindfulness training to standard hospital pain rehabilitation can improve outcomes for teens with chronic pain. Sixty participants aged 13-19 will be randomly assigned to either the app-enhanced program or…

This study is exploring if a very low dose of an existing drug, naltrexone, can help manage the severe pain and other symptoms of Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will take either the low-dose medication or a placebo pill daily for six months to see i…

This study gathers 30 experts—physiotherapists, midwives, gynaecologists, and more—to agree on the best way to teach pain science to pregnant women and new mothers. The goal is to create a standard education program that could help manage labour and postpartum pain. No treatments…

This study investigates if the dose of sufentanil, a strong painkiller given during planned abdominal surgery, is linked to chronic pain that lasts 3 months after the operation. Researchers will follow 855 adults having non-major abdominal surgery to measure pain levels and ident…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study tests whether people with chronic pain can drive safely while taking oral opioid medications. Using a driving simulator (like a video game), researchers measure attention, reaction time, and weaving. The goal is to provide better guidance to patients and doctors about …

This study looks at how blood pressure changes affect chronic pain in people who already have a spinal cord stimulator. About 36 adults with chronic low back pain and high blood pressure will take a standard blood pressure drug for 2 weeks and a placebo for 2 weeks. Researchers w…

This study aims to find brain-based markers that could help doctors better diagnose chronic pain and predict which treatments will work best. Researchers will use a device that gently stimulates the brain with magnetic pulses and records the brain's electrical responses in 100 ad…

This study involves 60 adults with chronic neck pain from cervical facet joints. Researchers want to see if muscle twitching during a standard radiofrequency ablation procedure can predict better pain relief. They will grade the twitching and compare it to how much pain decreases…

This study aims to find out if matching adults with chronic pain to a specific psychological treatment—like cognitive behavioral therapy, mindfulness, or hypnosis—based on their personal traits leads to better pain relief. Researchers are studying 331 adults to identify which fac…

This study looks at how the nervous system becomes extra sensitive in people with different kinds of long-term pain. Researchers will use surveys, thinking tests, and brain wave measurements to compare pain types. About 185 adults with chronic pain will be checked at the start an…

This study explores two experimental methods—Episodic Future Thinking (imagining positive future events) and Low-intensity Focused Ultrasound (using sound waves on the brain)—to see if they can reduce pain and alcohol cravings in people with both chronic pain and alcohol use diso…

This study looks at how green light exposure might change the way the brain processes pain. Researchers will measure brain activity in 30 healthy adults (ages 18–50) with no chronic pain. The goal is to understand the mechanism, not to test a treatment.

This study will follow 100 people with combat-related limb injuries to see if the way the injury happened (like the force and direction) can predict who will develop chronic pain. Researchers will measure pain levels and sensitivity at 3 and 6 months after the injury. The goal is…

This study follows 384 Brazilian patients who are using cannabis-based products prescribed by their doctors for chronic pain, anxiety, or depression. Researchers will not provide any treatment but will track patients' progress over 6 months through online questionnaires. The goal…