CHRONIC PAIN

This study tests a new way of managing chronic pain by improving teamwork between pain clinics, GPs, and other services. About 386 adults referred to pain clinics in Norway will either get this new pathway or standard care. The goal is to see if better coordination and a clear 6-…

This study aimed to test a closed-loop spinal cord stimulation device to reduce spasticity and pain in people who had a stroke or brain injury. It was designed for adults with chronic neuropathic pain and spasticity lasting more than three months. However, the trial was withdrawn…

This study compares two telemedicine approaches for people with chronic pain and opioid misuse. One program provides standard medication management via remote visits, while the other adds a 12-week self-help program with phone-based coaching. The goal is to see which approach bet…

This observational study is testing whether measuring the nociceptive flexion reflex (a spinal reflex) can predict which patients with chronic back or neck pain will get significant pain relief from interventional procedures like epidural injections or nerve blocks. Researchers w…

This study uses a device that combines magnetic stimulation and brain wave recording (TMS-EEG) to find biological markers for chronic pain. Researchers will measure brain responses in 100 adults with chronic pain and see if these signals can help diagnose pain types and predict h…

This study tests a small implanted device that sends mild electrical pulses to nerves to relieve chronic pain from injury or surgery. About 89 adults with long-lasting pain in the back, shoulder, knee, or foot will either get the implant plus usual care or usual care alone. The g…

This study tests whether adding monthly booster sessions to standard cognitive behavioral therapy (CBT) helps people with chronic pain manage their symptoms better over 18 months. About 716 military health system beneficiaries with chronic pain will receive either standard CBT or…

This study tests whether two non-invasive brain stimulation techniques—transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound (TUS)—can reduce chronic pain in people with diabetic neuropathy. Participants, aged 40 to 80 with foot pain lasting at least 6 months…

This study tests a 9-week virtual group program that teaches mindfulness, yoga, nutrition, and self-massage to help people with chronic pain. It is being offered at Federally-Qualified Health Centers, which serve low-income patients. The goal is to see if the program can be succe…

This study tests whether a directed massage technique works better than a classic symmetrical massage for people with long-term back or neck pain that hasn't improved with other treatments. Fifty adults aged 18 to 80 will receive both types of massage, and researchers will measur…

This study looks at whether pre-recorded yoga videos are as helpful as live online yoga classes for veterans with chronic pain. About 98 veterans will take part, first attending a 5-session primer, then practicing yoga for 12 weeks either on their own with videos or in a live VA …

This study tests whether a very low dose of naltrexone, a drug usually used for addiction, can reduce pain and other symptoms in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either the drug or a placebo for six months. The main goal is to…

This study tests a toolkit designed to help employees with chronic pain feel more confident managing their condition at work and stay productive. Over 600 workers from around 30 UK organizations will either use the toolkit or receive usual care. Researchers will measure work abil…

This study tests an 8-week program called PhYoMind, which blends physiotherapy, yoga postures, breathing exercises, and mindfulness, against home exercise alone in 40 adults with fibromyalgia. The goal is to see if the combined approach reduces disability, pain, fatigue, and stre…

This study tests a spinal cord stimulator that delivers fast-acting pain relief without the usual tingling sensation. About 177 adults with long-term back and limb pain will use the device. The main goal is to see if at least half of them get 50% or more pain reduction after 3 mo…

This study was designed to compare two types of nerve-blocking procedures for people with long-term knee pain from osteoarthritis. The goal was to see if targeting six nerves works better than the usual three nerves for reducing pain and improving daily function. The trial was wi…

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual…

This Phase 3 trial tests whether a nurse-led phone program can help rural veterans better manage chronic pain. Over 600 participants will receive either the program or a one-time education session, and researchers will track pain interference for 12 months. The goal is to improve…

This study tests whether getting Chuna manual therapy every two weeks for 20 weeks helps people with mild but long-lasting neck pain feel better and have fewer flare-ups. 250 adults with neck pain for over a year will be split into two groups: one gets the hands-on therapy, the o…

This study looks at two different ways to manage pain after lower back surgery without relying on drugs. About 267 adults will be randomly assigned to either standard care or an enriched pain management plan. The goal is to see which approach better reduces pain and helps people …

This study is testing a spinal cord stimulator that automatically adjusts its electrical pulses based on real-time nerve signals. The goal is to see if this smart device can better guide treatment for people with long-term pain in the trunk or limbs. The trial involves 250 partic…

This study compares two types of spinal cord stimulation—high frequency and burst—for treating chronic back and leg pain. Seven adults who are candidates for spinal cord stimulation will be randomly assigned to one waveform and tracked for at least 36 months. The goal is to see w…

This study tests a special spinal cord stimulator that automatically adjusts to your pain signals. It involves 70 adults with long-term pain in the back, arms, or legs. The goal is to see if the device safely reduces pain over time.

This study tests a small, battery-powered headband that delivers a gentle electrical pulse to the scalp to help reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is …

This study tests a 12-week Pain Self-Management (PSM) program for people with chronic pain and opioid misuse or opioid use disorder. Researchers want to see if the program helps participants manage pain better and stay in treatment for opioid use. About 204 adults from primary ca…

This study tests whether a group program called Partners4Pain, which teaches mind-body skills like meditation, relaxation, and gentle exercises, can reduce pain and improve daily life for people with chronic back or neck pain. About 376 adults will be randomly assigned to either …

This study tests a spinal cord stimulator (BurstDR) to relieve chronic pain from diabetic neuropathy. Twenty adults with long-lasting leg pain will try a temporary device for one week. If their pain drops by at least half, they can get a permanent implant. The study tracks pain l…

This study tests whether adding a non-invasive brain stimulation technique called rTMS to a three-week intensive pain rehabilitation program can help youth aged 10-18 with severe chronic pain. The goal is to see if the stimulation can reduce pain and improve daily function, mood,…

This study tests whether a nurse care management program can help rural adults with chronic pain feel better and function more in daily life. The program includes care coordination, cognitive behavioral therapy, and referrals to an exercise program. About 450 rural patients will …

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study is testing a new device that uses gentle vibrations on the belly, back, or temples to help people with chronic pain conditions like pelvic pain, abdominal pain, low back pain, or migraine. About 50 adults will try the real device or a placebo to see if it safely reduce…

This study tests whether a digital version of cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in 140 adults with chronic pain and insomnia. Participants will either receive the digital CBT-I program or digital sleep hygiene education. The goal …

This study is testing a new program led by physiotherapists to help teens and young adults (ages 12-25) who have had muscle or joint pain for at least 3 months. The program focuses on gradually increasing physical activity and reducing fear of movement. The goal is to see if this…

This study tests a new way to use deep brain stimulation for people with severe, treatment-resistant chronic pain from stroke, spinal cord injury, or phantom limb pain. Instead of constant stimulation, the device delivers electrical pulses only when the brain senses high pain sig…

This study tests two telehealth-based treatments—brief pain education and 10 weeks of physical therapy—to help 500 adults with chronic low back pain. The goal is to improve pain management and reduce opioid use in community health centers. Participants receive sessions via phone …

This study explores whether low-intensity focused ultrasound (LIFU) can temporarily change brain activity to reduce chronic pain. Eighty adults with moderate-to-severe pain lasting at least 3 months will receive brain scans, pain tests, and questionnaires over 10 weeks. The goal …

This study tests whether stationary cycling (at a voluntary or assisted pace) and a type of psychotherapy called I-STOP can reduce drug cravings in adults with opioid use disorder and chronic pain. About 198 people in residential treatment will try these approaches alone or toget…

This study looks at whether adding a mobile app that guides teens through physical exercise and mindfulness training can make standard pain rehabilitation more effective. About 60 teens aged 13-19 with long-term pain will either get the app plus a shorter hospital program, or the…

This study compares two types of nerve blocks—interscalene and suprascapular—for controlling pain after arthroscopic shoulder surgery. 84 adults having shoulder arthroscopy will receive one of the blocks, and researchers will measure pain levels and side effects. The goal is to f…

This study looks at whether a special type of massage therapy, designed to be sensitive to trauma and different cultures, can help refugees and asylum seekers who survived torture or war. About 50 people will either get their usual care plus this massage, or just usual care. The …

This study tests whether combining pain neuroscience education (teaching patients about how pain works) with a gradual, timed increase in physical activity can reduce chronic pain in breast cancer survivors. About 122 survivors who have finished cancer treatment will be randomly …

This study tests a small, implantable device that stimulates nerves to relieve chronic pain after injury or surgery. About 185 adults with peripheral neuralgia will either receive the stimulator plus standard medical care or standard care alone. The goal is to see if the device p…

This study compares two exercise programs for adults aged 65 and older living in residential care. One group does short, frequent 'exercise snacks' twice a day, while the other does longer, structured sessions a few times a week. Over 12 weeks, researchers will measure changes in…

This study tests two approaches to help people with opioid use disorder and chronic pain feel better. One is a pain self-management program with coaching and peer support. The other allows flexible dosing of buprenorphine based on pain levels. 268 adults from participating clinic…

This study planned to test whether a small vibrating bee with ice-pack wings, called Buzzy, could reduce pain during IV placement in adults with chronic pain who receive lidocaine infusions. Participants would have rated their pain and satisfaction after IV insertion. However, th…

This study tests whether a brief education and self-management program with home exercises can reduce pain and improve daily function in adults with long-lasting jaw pain (TMD) as effectively as more intensive hands-on physiotherapy. Forty adults aged 18–65 with jaw pain for at l…

This study explores whether shining specific colors of light into the eyes can help people with chronic low back pain or fibromyalgia feel less pain. Sixty adults will use a portable light device for 2 hours daily over 5 days. The goal is to see if this approach is practical and …

This study tests whether a nasal spray containing oxytocin, a natural hormone, can reduce pain and improve function in people with chronic pain. About 336 adults with nerve, muscle, or pelvic pain will try two doses of oxytocin and a placebo spray over several weeks. The goal is …

This study tests whether yoga can reduce nerve pain caused by chemotherapy in cancer survivors. About 227 participants will either take yoga classes twice a week for 8 weeks, attend educational sessions, or receive standard care. Researchers will measure pain, balance, fall risk,…

This study tests a personalized yoga coaching program for people with lupus who have chronic pain. Fifteen participants work with a coach to create a yoga practice that fits their needs and limits. The goal is to see if the program is feasible and if it helps reduce pain. It is a…

This study tests whether daily listening to jazz music combined with mindfulness can reduce chronic pain and anxiety. About 90 adults with chronic pain and moderate-to-severe anxiety will listen to jazz recordings daily for 4 weeks. Researchers will measure changes in pain intens…

This study looks at whether a digital health program (Hinge Health) plus a wearable pain relief device (Enso) can help people with chronic low back pain feel better and move more easily. About 196 adults with back pain for at least 3 months will be randomly assigned to either the…

This study looks at whether a single session of mild electrical brain stimulation (tDCS) over the cerebellum can help reduce pain in women with fibromyalgia. About 92 right-handed women aged 18-65 with confirmed fibromyalgia and moderate-to-severe pain will receive the stimulatio…

This study looked at whether taking a probiotic supplement for 8 weeks could reduce inflammation and pain in teenagers (ages 13-17) who have chronic pain and a body mass index at or above the 85th percentile. Researchers measured changes in a blood marker of inflammation (C-react…

This study tests whether a combined therapy (Acceptance and Commitment Therapy plus Mindfulness-Based Relapse Prevention) can reduce how much pain interferes with daily life in veterans who have both chronic pain and opioid use disorder. About 157 veterans taking buprenorphine fo…

This study tests an 8-week app-based breathing program that uses heart rate feedback to help people with chronic migraine. Thirty adults will use the app daily for 10 minutes, and researchers will track changes in migraine frequency and psychological well-being. The goal is to se…

This study tests whether doing electrotherapy and neck exercises at home via video calls works as well as doing them in a clinic. One hundred adults with chronic neck pain will be split into two groups: one doing a remote program and one doing in-person sessions. Both groups will…

This study looks at adults with chronic pain who receive ketamine infusions at Stanford's Pain Management Center. Researchers want to understand which patients improve and what factors predict a good response. The goal is to better tailor this treatment to individuals.

This study compares a multidisciplinary treatment (combining pain management, pelvic floor therapy, and mucosal care) with standard care for women suffering from chronic vulvar pain (vulvodynia) lasting at least 3 months. About 106 women aged 18 and older will participate. The go…

This study compares personalized electro-acupuncture and auricular-acupuncture against usual care for treating chronic pain in adults with musculoskeletal pain or fibromyalgia. Participants are split into three groups: two receive different acupuncture methods, and one receives s…

This study tests a program called COMPASS-NP for home care workers who have chronic pain. The program combines pain education, coping strategies, and safety tips, led by a trained peer. About 140 workers will take part to see if it reduces how much pain interferes with their work…

This study tests whether a single, two-hour pain relief skills session called Empowered Relief can reduce chronic pain after a cesarean delivery. Sixty women who still have moderate to severe pain six weeks after their C-section will attend the session and be followed for 12 week…

This study tests whether daily exposure to green LED light can reduce chronic pain. 55 adults with conditions like fibromyalgia or nerve pain will use a green or white light device at home for 2 hours each day over 3 months. Researchers will measure changes in pain levels, medica…

This study tests a treatment that combines two therapies (ACT and MBRP) to help people with both chronic pain and opioid use disorder. About 160 adults already on buprenorphine will be randomly assigned to either this combined therapy or their usual care. The goal is to see if th…

This study tests whether a single dose of ketamine, given while patients are sedated, can reduce chronic pain and depression symptoms. Forty adults with both conditions will receive either ketamine or a placebo (saline) during sedation with propofol. Researchers will track pain a…

This study tested whether two types of gentle brain stimulation (tDCS and TUS) can reduce pain and improve daily function in people with chronic knee osteoarthritis. 64 adults with persistent knee pain received either real or sham stimulation. Researchers measured changes in pain…

This study tests whether two types of gentle brain stimulation—tDCS and TUS—can reduce pain and improve daily function in people with chronic low back pain. Researchers will compare active stimulation to a sham (fake) treatment in 40 adults aged 18-85 who have had persistent back…

This trial gave multiple infusions of a patient's own stem cells to treat chronic muscle and joint pain that had lasted at least a year. The patient received six infusions over about 32 weeks, with safety checks and pain scores tracked throughout. The goal was to see if this appr…

This study tests whether a mindfulness program called MORE can help people with long-term cancer pain. 76 adults with a history of cancer and ongoing pain will either learn mindfulness skills or continue their usual care. The goal is to see if this approach is practical and helpf…

This study tests a psychological treatment called Pain Reprocessing Therapy (PRT) for people with chronic widespread pain, including fibromyalgia. PRT teaches patients that pain can come from 'stuck' brain patterns and helps them retrain their brain to stop sending false pain ala…

This study tests whether a gentle electrical brain stimulation device, used at home, can reduce chronic pain in people with rheumatoid arthritis whose inflammation is already well-controlled. Thirty-four participants will either receive real or sham stimulation over several sessi…

This study compares three psychological treatments—CBT, ACT, and EAET—for adults with chronic back or neck pain. Researchers want to understand how each therapy works and which patients benefit most. 408 participants will receive weekly online therapy for 8 weeks and be followed …

This study surveys 350 adults with hemophilia to better understand chronic pain—its type, location, and impact on daily life. Participants fill out questionnaires about their pain history, medication use, and emotional well-being. The goal is to help doctors recognize and treat p…

This study aims to develop a screening test for a pain control mechanism called DNIC, which is often faulty in people with chronic pain. Researchers will use cameras to capture facial expressions during pain tests and apply artificial intelligence to see if they can automatically…

This study looks back at medical records of 200 adults with Complex Regional Pain Syndrome (CRPS) to see which pain treatments doctors actually use first and how well they work. Researchers want to find patterns that could help choose the best treatment for each person. No new tr…

This study gathers opinions from 30 healthcare experts, including physiotherapists and midwives, to decide the best way to teach women about pain during and after childbirth. The goal is to create a standard pain education program that can be tested in future studies. No treatmen…

This study looks at how the nervous system becomes overly sensitive in people with different types of chronic pain. Researchers will assess 185 adults using questionnaires, thinking tests, and laser brain-wave measurements at the start and after one year. The goal is to better un…

This study aims to see if a short, 4-question Turkish version of the Pain Anxiety Symptom Scale is a reliable and valid tool for measuring pain-related anxiety. Researchers will enroll 350 adults aged 18-65 who have had chronic pain for at least 3 months. Participants will fill o…

This observational study will follow 384 patients in Brazil who are using cannabis-based products (like CBD or THC oils) prescribed by their own doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients' quality of life,…

This study looks at whether matching adults with chronic pain to specific psychological treatments—like cognitive behavioral therapy, mindfulness, or hypnosis—based on their personal traits (such as brain activity or thinking patterns) leads to better pain relief. Researchers wil…

This study follows 100 people with combat-related limb injuries to see if the mechanics of the injury—like force and direction—can predict who will develop chronic pain. Researchers will track pain levels at 3 and 6 months. The goal is to find early warning signs so doctors can s…

This study looks at whether imagining positive future events (Episodic Future Thinking) and using low-intensity focused ultrasound on the brain can help people with both chronic pain and alcohol use disorder. Ten adults will try these interventions and report changes in pain, cra…

This study uses a driving simulator to test whether people with chronic pain can drive safely while taking oral opioids. 450 participants with a valid driver's license will be tested on measures like weaving and reaction time. The goal is to provide better guidance to patients an…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study tests whether green light can reduce pain by looking at brain activity in 30 healthy adults. Participants are exposed to green or white light for two hours while researchers measure pain pathways and brain waves. The goal is to understand how green light works, not to …

This study looks at whether the dose of sufentanil, a strong painkiller given during non-major abdominal surgery, is linked to chronic pain 3 months after the operation. Researchers will interview 855 patients by phone to check for pain and its severity. The goal is to identify a…

This study aims to create a decision aid to help patients on long-term opioid therapy and their doctors have better conversations about safely reducing or stopping opioids. Researchers will interview patients and doctors to understand their experiences, then test the tool with 30…

This study was designed to explore what kinds of feelings (like touch or tingling) could be created by electrically stimulating the spinal cord in people with amputations who experience phantom limb pain. Researchers planned to work with patients who already had a spinal cord sti…

This study looks at whether muscle twitching in the neck during a standard pain treatment (radiofrequency ablation) can help predict who will get good pain relief. Researchers will grade twitching in 60 adults with chronic neck pain and then check if those with more twitching had…

This early-phase study looks at whether a common blood pressure drug, hydrochlorothiazide, can affect chronic pain in people who already have a spinal cord stimulator implant. About 36 adults with chronic low back pain and high blood pressure will take the drug or a placebo for t…