CHRONIC PAIN

This study aimed to test a spinal cord stimulator (an implanted device) to reduce chronic muscle stiffness (spasticity) and pain in people who have had a stroke. The device was designed to send electrical signals to the spinal cord to calm overactive nerves and muscles. The goal …

This study is testing if a shorter, 6-week hospital-based pain rehabilitation program, combined with 6 weeks of at-home exercise and mindfulness training delivered by a mobile app, works as well as the standard 12-week hospital program alone. It involves about 60 teenagers (ages …

This study is developing a new type of 'smart' brain implant for people with severe, untreatable chronic pain from conditions like stroke, spinal cord injury, or phantom limb pain. The device listens for the brain's own pain signals and delivers stimulation only when pain is high…

This study aims to find out if the amount of a specific anesthesia drug (sufentanil) given during common abdominal surgeries is linked to patients developing long-term pain months later. It will follow 855 adults having scheduled, non-major abdominal surgery. The goal is to see i…

This study is testing a new combined therapy for people who have both long-term chronic pain and an addiction to opioid painkillers. About 160 people already receiving standard medication treatment will try either the new therapy or continue with their usual care. The goal is to …

This study is testing a telehealth therapy program designed to help veterans who are dealing with both long-term chronic pain and an opioid use disorder. It compares a special therapy that combines mindfulness and acceptance techniques against a standard education program. The go…

This study compares two telehealth support programs for adults with chronic pain who are on long-term opioid therapy. It tests whether adding a virtual self-management coaching program to a standard pharmacist-led care model is more effective. The goal is to help people better ma…

This study is testing a new, structured treatment plan for people with chronic pain. It involves doctors from different parts of the healthcare system, including your regular GP, working together in video meetings to create a six-month care plan. Researchers will compare this new…

This study is testing a nurse care management program designed to help adults in rural areas who live with chronic pain. The program provides care coordination, teaches coping skills through therapy, and helps connect patients to a home-based exercise program. The goal is to see …

This study is observing how well a new type of spinal cord stimulator works for people with long-term, hard-to-treat pain. The device, called evoke®, is already approved and being used in real-world patients. Researchers are tracking 25 adults with severe chronic pain to see how …

This study is testing whether a probiotic supplement can reduce body-wide inflammation in teenagers who have chronic pain and a higher body weight. Researchers want to see if lowering inflammation also leads to less pain and better daily function. The study involves 39 teens aged…

This study aimed to see if a device called Buzzy® could make getting an IV less painful for adults with chronic pain. The Buzzy combines cold and vibration and is placed on the arm before the needle goes in. The trial planned to compare pain levels between using the device and us…

This study is testing two different virtual group programs to help older adults who have both chronic pain and early signs of memory decline. The programs aim to improve physical function, thinking skills, and emotional well-being through guided sessions. Researchers want to see …

This study is testing whether a gentle, non-invasive ultrasound device can temporarily change brain activity to help manage chronic pain. Participants will have brain scans to guide the device and then undergo controlled pain tests to measure any changes in their pain perception.…

This study aims to see if a simple education and home exercise program works as well as more intensive hands-on physiotherapy for adults with long-term jaw pain. Researchers will compare pain levels and daily function in 40 participants randomly assigned to one of the two treatme…

This study is testing two ways to help people who are being treated for opioid addiction and also have severe chronic pain. Researchers are comparing pain coaching sessions and a flexible medication dosing plan against usual care. The goal is to see if these approaches help reduc…

This study is testing whether a digital health program (Hinge Health) combined with a wearable pain relief device (Enso) works better than standard care for people with chronic lower back pain. The program includes exercises, education, and coaching, while the device uses gentle …

This study is testing a new type of spinal cord stimulator for people with chronic pain in their back or limbs. The device is 'smart'—it listens to the body's nerve signals and automatically adjusts its stimulation to try to provide better pain relief. Researchers are enrolling 2…

This study is testing if a single online class teaching pain relief skills can help reduce chronic pain for women after a cesarean delivery. It will enroll 60 women from Stanford who still have moderate to severe pain six weeks after their C-section. The main goal is to see if th…

This study is exploring if a very low dose of an existing medication, naltrexone (called LDN), can help manage the severe pain and other symptoms of Complex Regional Pain Syndrome (CRPS). Over six months, 40 participants will take either LDN or a placebo (inactive pill) daily to …

This study is testing a small, implanted device that sends mild electrical pulses to nerves to see if it helps reduce chronic pain from injuries or surgery. It compares the device plus standard pain care against standard pain care alone. The goal is to see if the device helps mor…

This study tests a community health worker program called RESET, designed to help older adults in Detroit manage symptoms like depression, anxiety, chronic pain, and loneliness. Over 450 participants will join group phone calls, listen to podcasts, and use activity trackers to bu…

This study is exploring whether listening to jazz music, sometimes combined with mindful listening techniques, can help reduce pain for people with chronic pain conditions. About 90 adults with chronic pain will be assigned to either listen to jazz daily for four weeks, listen mi…

This small study is testing whether a personalized, virtual yoga coaching program is a practical way to help people with lupus manage their chronic pain. Researchers are working with 15 participants to see if they can successfully recruit people and have them complete the 13-week…

This study is testing whether spinal cord stimulation can help reduce chronic nerve pain in the limbs of people with diabetes. Researchers are measuring how much pain relief participants experience over 12 months and whether they feel their condition has improved. The study invol…

This study is testing whether a single dose of ketamine works better than a placebo (saltwater) for reducing chronic pain and depression. The key twist is that participants are sedated and asleep when they receive the infusion, so they won't consciously feel its effects. Research…

This study is testing whether a safe, non-invasive brain stimulation device used at home can help reduce chronic pain in people with rheumatoid arthritis. It will involve 34 adults whose arthritis is under control but who still experience significant pain. The goal is to see if t…

This study aims to see if two specific types of acupuncture work better than usual medical care for reducing chronic pain. It involves 360 adults, primarily cancer survivors, who have had musculoskeletal pain for at least three months. Participants are assigned to receive either …

This study aims to see if combining a brain stimulation technique (low-intensity focused ultrasound) with a mental exercise (thinking about positive future events) can help people who suffer from both chronic pain and alcohol use disorder. Ten participants will try different comb…

This study is testing whether a combination of pain education and gradual activity training can better reduce chronic pain for breast cancer survivors compared to standard care. It involves 122 survivors who have finished their main cancer treatment but still experience significa…

This study is testing whether a small, implanted device that sends gentle electrical pulses to nerves works better than standard pain medications alone. It involves adults with long-term nerve pain in areas like the back, shoulder, knee, or foot, caused by past injuries or surger…

This study compares two nerve block techniques used to control pain after shoulder surgery. Researchers want to see if a newer method (suprascapular block) provides similar pain relief as the standard method (interscalene block) but with fewer breathing-related side effects. The …

This study is testing whether a 9-week digital sleep therapy program, delivered through a smartphone app, can help people who have both chronic pain and insomnia. It will compare the app-based therapy to basic sleep education to see which is better at reducing sleep problems and …

This study tests whether community health workers can effectively teach pain management strategies to older adults with chronic pain. Over 400 primarily African American older adults will receive 7 weeks of phone sessions and mobile tools to learn coping skills, compared to a gro…

This study is testing whether a smartphone app that guides daily breathing exercises can help reduce migraine frequency and severity. Researchers will enroll 30 adults with chronic migraines to try the 8-week app program or a sham control. The main goal is to see if the app is pr…

This study is testing whether a coordinated team approach is better than standard care for reducing chronic vulvar pain (vulvodynia). It will involve 106 women who will be randomly assigned to receive either the team-based treatment or standard care from a gynecologist. The goal …

This study is testing whether mindfulness training can help reduce chronic pain in people with cancer. Researchers are comparing a mindfulness program called MORE against a waitlist control group in 76 participants. The goal is to see if teaching people to focus on the present mo…

This study is exploring whether looking at specific colors of light can help reduce chronic pain. Researchers are testing the approach in 60 adults with fibromyalgia or chronic low back pain. The main goal is to see if the light therapy is practical to use and to understand how i…

This study is testing a new type of spinal cord stimulator designed to relieve chronic pain quickly and without the usual tingling sensation. It involves 177 adults with long-term back and limb pain. The main goal is to see how many people get at least 50% pain reduction three mo…

This study is testing whether yoga can help reduce nerve pain caused by chemotherapy, a common side effect for cancer survivors. Researchers are comparing yoga classes to educational sessions and standard medical care to see which best improves pain, balance, and quality of life.…

This study is testing a new type of talk therapy called Pain Reprocessing Therapy (PRT) for people with chronic widespread pain, including fibromyalgia. It aims to see if this therapy can reduce pain levels and improve mood, sleep, and daily activities. The study is small, enroll…

This study compares two exercise programs for older adults living in residential care. It tests whether short, frequent bursts of activity ('exercise snacking') are as good as longer, traditional exercise sessions at improving physical fitness, thinking skills, and chronic pain. …

This study is testing whether adding electrical dry needling to a standard exercise program works better than exercise alone for people with long-term, unexplained neck pain. It involves 70 adults who have had neck pain for at least three months. Researchers will measure changes …

This study is testing whether a nasal spray containing oxytocin, a natural body chemical, can help manage chronic pain. Over 300 adults with long-term nerve, muscle, or pelvic pain will try two different doses of the spray and a placebo spray over several weeks. Researchers will …

This study aims to see if treating chronic neck pain from home is as effective as going to a clinic. It will enroll 100 adults with long-term neck pain and randomly assign them to receive either remote (via phone/computer) or in-person therapy. Both groups will get the same 8-wee…

This program provided expanded access to an experimental stem cell treatment for adults with severe, long-term musculoskeletal pain. Participants received multiple intravenous infusions of a specific type of stem cell (HB-adMSCs) over about 32 weeks. The main goals were to check …

This study is testing whether a gentle, non-invasive electrical brain stimulation technique can help reduce pain in people with fibromyalgia. Researchers will apply a mild current to the brain's surface for 20 minutes during a single session. They will measure changes in particip…

This study is testing a small, implanted device that sends electrical pulses to the spinal cord to reduce chronic pain caused by diabetic nerve damage. Adults with painful diabetic neuropathy who haven't gotten enough relief from medications will first try the stimulation for one…

This study is comparing two ways to manage severe pain from cancer. One group gets a small pump implanted near the spine to deliver pain medicine directly. The other group continues with standard pain pills. Researchers will track which method better controls pain, reduces medica…

This study is testing whether two types of non-invasive brain stimulation can reduce pain and improve function for people with long-term, medication-resistant low back pain. Researchers are comparing active stimulation to a fake (sham) treatment in 40 participants to see if it ma…

This study is testing whether daily exposure to green LED light can reduce chronic pain. Researchers are comparing green light to white light in 55 adults with conditions like neuropathy, fibromyalgia, or headaches. Participants sit near the light at home for two hours daily for …

This study tested whether two types of non-invasive brain stimulation could reduce pain and improve daily function for people with chronic knee osteoarthritis. Researchers compared real stimulation to a fake (sham) treatment in 64 participants to see if it lowered their pain scor…

This study aims to understand if people with chronic pain can drive safely while taking opioid medications. Researchers will test 450 participants using a driving simulator that measures attention and reaction time. The goal is to gather evidence about driving restrictions that a…

This study aims to understand if lowering blood pressure can help manage chronic pain. It involves 36 adults who have both chronic back pain and high blood pressure, and who already have a permanent spinal cord stimulator. Participants will take a standard blood pressure pill (a …

This study aims to understand why some people with chronic pain get relief from ketamine infusions while others do not. Researchers will follow 100 patients at Stanford's Pain Management Center for up to a year after their treatment. By collecting survey data and medical records,…

This study aims to understand how three different types of chronic pain affect the brain's pain processing system. Researchers will follow 185 patients for one year, using questionnaires and brain tests to measure changes. The goal is to gather knowledge that could lead to more p…

This study aims to find brain activity patterns that could help doctors better understand and diagnose chronic pain. Researchers will use a special helmet that gently stimulates the brain and records its electrical response in 100 adults with long-term pain. The goal is to see if…

This study aims to understand if the specific way a combat limb injury happens can predict who will develop long-term chronic pain. Researchers will observe 100 veterans with recent combat-related limb injuries, tracking their pain levels over 6 months. The study does not test an…

This study aims to understand how genetics, lifestyle, and other factors influence the progression and severity of many common chronic diseases. Researchers will collect health records, genetic data, and samples from 120,000 participants with conditions like diabetes, arthritis, …

This study aims to understand how looking at green light might reduce pain. Researchers are testing 30 healthy volunteers to see if green light changes how the brain sends and blocks pain signals. Participants sit under green or white light for two hours while researchers measure…

This study aims to learn how to match adults with chronic pain to the talk therapy most likely to help them. Researchers are testing if brain activity and personal traits can predict who benefits most from Cognitive Behavioral Therapy (CBT), mindfulness therapy, or hypnotherapy. …

This study aims to find out if a simple observation during a standard neck pain treatment can predict how well it works. Researchers will watch for muscle twitching in 60 patients undergoing a procedure called radiofrequency ablation for chronic neck pain. They want to see if mor…