Could the 'Love Hormone' help ease chronic pain?

NCT ID NCT04903002

Ongoing Symptom relief Sponsor: Memorial University of Newfoundland Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a nasal spray containing oxytocin, a natural hormone, can reduce pain and improve function in people with chronic pain. About 336 adults with nerve, muscle, or pelvic pain will try two doses of oxytocin and a placebo spray over several weeks. The goal is to see if oxytocin provides better pain relief than a placebo without the side effects of many pain medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oxytocin nasal spray
What this could lead to: If it works, this could offer a new, non-addictive option for managing chronic pain and improving daily function.
What could go wrong: This is a mid-stage trial; results may not show a clear benefit over placebo, and effects could be modest or short-lived.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PAIN

Contacts and locations

Locations

Calgary Chronic Pain Centre

Calgary, Alberta, T2T 5C7, Canada
Carbonear General Hospital

Carbonear, Newfoundland and Labrador, A1Y 1A4, Canada
Jim Pattison Outpatient Care & Surgical Centre Pain Clinic (JPOCSC-PC)

Surrey, British Columbia, V3T0G9, Canada

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